Rheumatoid arthritis in patients with hemoglobinopathies

Pliakou, Xanthi; Koutsouka, Frideriki P.; Damigos, D.; Bourantas, Konstantinos L.; Briasoulis, Evangelos

doi:10.1007/s00296-011-2125-2

Cited by 13 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rheumatoid arthritis may further become an issue in ageing thalassaemia populations. In a single‐centre adult cohort of 90 patients with haemoglobinopathies, 4 patients fulfilled the American College of Rheumatology criteria for rheumatoid arthritis 52 …”

Section: The Evolving Spectrum Of Comorbiditiesmentioning

confidence: 99%

The changing epidemiology of the ageing thalassaemia populations: A position statement of the Thalassaemia International Federation

Farmakis

Giakoumis

Angastiniotis³

et al. 2020

European J of Haematology

View full text Add to dashboard Cite

Therapeutic advances in β‐thalassaemia have gradually lead to a significant improvement in prognosis over the past few decades. As a result, patients living in areas where disease‐specific programmes offering access to modern therapy are in place experience a new era of prolonged survival that tends to reach that of the normal population. This ageing thalassaemia population, however, faces a new spectrum of comorbidities resulting from increasing age that may jeopardise the advances in prognosis provided by current therapy and thus poses new challenges in diagnosis, monitoring and treatment. In this position paper of the Thalassaemia International Federation, we review the changing epidemiology and clinical spectrum of patients with β‐thalassaemia and propose actions to be undertaken in order to address the emerging spectrum of comorbidities resulting from ageing.

show abstract

Section: The Evolving Spectrum Of Comorbiditiesmentioning

confidence: 99%

The changing epidemiology of the ageing thalassaemia populations: A position statement of the Thalassaemia International Federation

Farmakis

Giakoumis

Angastiniotis³

et al. 2020

European J of Haematology

View full text Add to dashboard Cite

show abstract

“…Interestingly, this disease can increase the frequency of the appearance of RA. This may be caused by iron deposition into synovial tissues or to iron chelators such as deferiprone due to the production of free radicals during iron exchange [ 34 ].…”

Section: Biochemistry Absorption and Metabolism Of Seleniummentioning

confidence: 99%

The Relevance of Selenium Status in Rheumatoid Arthritis

Turrubiates-Hernández

Márquez‐Sandoval

González-Estévez

et al. 2020

Nutrients

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that can cause joint damage. Among the environmental risk factors, diet plays an important role because it can aggravate or attenuate inflammation. Selenium (Se) is considered an essential trace element since it is a structural component of antioxidant enzymes; however, its concentration can be affected by diet, drugs and genetic polymorphisms. Studies have reported that RA patients have a deficient diet in some food groups that is associated with parameters of disease activity. Furthermore, it has been shown that there is an alteration in serum Se levels in this population. Although some clinical trials have been conducted in the past to analyze the effect of Se supplementation in RA, no significant results were obtained. Contrastingly, experimental studies that have evaluated the effect of novel Se nanoparticles in RA-induced models have shown promising results on the restoration of antioxidant enzyme levels. In particular, glutathione peroxidase (GPx) is an important selenoprotein that could have a modulating effect on inflammation in RA. Considering that RA patients present an inflammatory and oxidative state, the aim of this review is to give an overview of the current knowledge about the relevance of Se status in RA.

show abstract

“…Of interest, this disease can increase the frequency of RA appearance. This might be a result of the deposition of iron in the synovial tissues or because of iron chelators due to the generation of ROS in iron exchange [ 22 ].…”

Section: Natural Dietary Seleniummentioning

confidence: 99%

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

2021

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a common chronic inflammation-mediated disorder having systematic complications. RA triggers a self-directed inflammatory and immunological cascade that culminates in joint destruction. Though a range of treatment options are available, none of them are without adverse effects and this has led researchers to search for alternative solutions. Nanomedicine has emerged as a powerful therapeutic alternative, and selenium (Se) is an essential micronutrient trace element that has a crucial role in human health and disease. Selenium nanoparticles (SeNPs) derived from biological sources, such as plants, bacteria, fungi, and proteins, have exhibited remarkable candidate properties and toxicological profiles, and hence have shown potential to be used as antirheumatic agents. The potential of SeNPs can be attributed to the effect of functional groups bound to them, concentration, and most importantly to their nano range size. The antirheumatic effect of SeNPs is considerable due to its potential in amelioration of oxidative stress-mediated inflammation via downregulation of radical and nonradical species, markers of inflammation, and upregulation of inherent antioxidant defenses. The size and concentration impact of SeNPs has been shown in the subsequent antioxidant and anti-inflammatory properties. Moreover, the article emphasizes the role of these biogenic SeNPs as a notable option in the nanomedicine arena that needs to be further studied as a prospective remedial alternative to cure RA and medication-related adverse events.

show abstract

Rheumatoid arthritis in patients with hemoglobinopathies

Cited by 13 publications

References 18 publications

The changing epidemiology of the ageing thalassaemia populations: A position statement of the Thalassaemia International Federation

The changing epidemiology of the ageing thalassaemia populations: A position statement of the Thalassaemia International Federation

The Relevance of Selenium Status in Rheumatoid Arthritis

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

Contact Info

Product

Resources

About