Rheumatoid arthritis is associated with KIR2DS4-full among the KIR genes in Lur Population of Iran

Ansari-Moghaddam, Bijan; Kiani, Ali Asghar; Sheikhian, Ali; Birjandi, Mehdi; Ahmadi, Seyyed Amir Yasin; Mousavi, Nazanin; Torang, Hamzeh Ali; Shahsavar, Farhad

doi:10.52547/rbmb.10.1.84

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Rheumatoid arthritis is a common systemic and autoimmune disease in which the pathophysiology underlying its development and progression is a result of dysregulations of the immune system (11). Its primary pathological characters are synovitis and vasculitis.…”

Section: Discussionmentioning

confidence: 99%

HOTAIR and THRIL Long Non Coding RNAs and Their Target Genes in Rheumatoid Arthritis patients

et al. 2022

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Background: Rheumatoid arthtritis (RA) is a chronic systemic inflammatory autoimmune disease characterized by irreversible joint damage and deformity. The aim of this study is to investigate THRIL and HOTAIR serum expression and their target genes in Egyptian RA patients and to evaluate their relationship to the clinico-pathological data. Methods: The present study included fifty-two RA patients and fifty-six healthy controls. RA patients were classified according to DAS28 score. All subjects were subjected to full history taking and clinical examination. Quantitative real time PCR was done to estimate the expression levels of serum THRIL and HOTAIR as well as their target genes tumor necrosis factor alpha (TNF-α) and metalloproteinase 2 (MMP-2) were estimated by ELISA techniques. Results: Results revealed that both THRIL and HOTAIR were statistically over expressed in RA patients compared to healthy group with p-value< 0.05. Results showed as well that the target genes for those longnon coding RNAs, TNF-α and MMP-2, were also significantly higher in RA patients compared to healthy controls. Conclusions: Both THRIL and HOTAIR associated with their target genes, can be considered as diagnostic markers for RA.

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Section: Discussionmentioning

confidence: 99%

HOTAIR and THRIL Long Non Coding RNAs and Their Target Genes in Rheumatoid Arthritis patients

et al. 2022

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“…Through cytokine production, these cells maintain a cross-talking process, and their activation promotes the secretion of enzymes and other chemicals that contribute to cartilage and bone tissue degradation (3,4). Tlymphocytes, in particular, play a crucial role in RA pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Potential Role of circRNA-HIPK3/microRNA-124a Crosstalk in the Pathogenesis of Rheumatoid Arthritis

et al. 2022

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Background: Circular RNA-HIPK3 (CircHIPK3) has been shown to be aberrantly expressed in a variety of diseases, contributing to disease initiation and progression. The aim of the present study is to investigate the role of the circHIPK3 RNA/microRNA-124a interaction in the pathogenesis of rheumatoid arthritis (RA). Methods: This study included 79 RA patients and 30 control individuals. The patients involved were classified according to the disease activity score (DAS28) into mild (24 patients), moderate (24 patients), and severe (31 patients). Serum samples were collected to estimate the relative gene expression of circHIPK3 RNA and its target gene microRNA-124a by quantitative real time-PCR. Moreover, ELISA was used to detect the serum levels of monocyte chemoattractant protein-1 (MCP-1). Routine laboratory estimation of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF) was also done. Results: In all grades of RA groups, there was a significantly substantial elevation of circHIPK3 RNA gene expression, with subsequent downregulation of miRNA-124a when compared to the control group. CircHIPK3 and microRNA-124a expression have been established to be inversely linked. Also, estimation of serum levels of MCP-1, ESR, CRP, and RF exhibited a significant increase in all grades of RA as compared to the control group. Conclusions: CircHIPK3 and microRNA-124a might be regarded as key players in the pathogenesis of RA. The cross-talk between them appears to be responsible for inducing joint inflammation by increasing MCP-1 production. Targeting circHIPK3 and microRNA-124a, and their downstream adaptor molecules, poses a new challenge for RA therapy.

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The impact of killer cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA) class I ligands on predisposition or protection against prostate cancer

et al. 2023

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Rheumatoid arthritis is associated with KIR2DS4-full among the KIR genes in Lur Population of Iran

Cited by 4 publications

References 44 publications

HOTAIR and THRIL Long Non Coding RNAs and Their Target Genes in Rheumatoid Arthritis patients

HOTAIR and THRIL Long Non Coding RNAs and Their Target Genes in Rheumatoid Arthritis patients

Potential Role of circRNA-HIPK3/microRNA-124a Crosstalk in the Pathogenesis of Rheumatoid Arthritis

The impact of killer cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA) class I ligands on predisposition or protection against prostate cancer

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