Clinical Management of Complicated Urinary Tract Infection 2011
DOI: 10.5772/24417
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Rheumatoid Arthritis is Caused by Asymptomatic Proteus Urinary Tract Infections

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Cited by 8 publications
(8 citation statements)
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“…P. mirabilis infections have also been frequently reported in urine samples from patients with RA (Senior et al, 1999). Furthermore, P. mirabilis antibodies from RA patients have cytopathic effects on joint tissue possessing P. mirabilis cross-reactive antibodies (Rashid & Ebringer, 2011) and sera from rabbits immunised with HLA-DR4 positive lymphocytes bind specifically to Proteus (Ebringer et al, 1985). Amino acid sequence homologies have been identified between the 'EQ/KRRAA' motif present in RA HLA-susceptibility antigens and the 'ESRRAL' amino acid sequence present in P. mirabilis haemolysins (Ebringer et al, 1992).…”
Section: Introductionmentioning
confidence: 97%
“…P. mirabilis infections have also been frequently reported in urine samples from patients with RA (Senior et al, 1999). Furthermore, P. mirabilis antibodies from RA patients have cytopathic effects on joint tissue possessing P. mirabilis cross-reactive antibodies (Rashid & Ebringer, 2011) and sera from rabbits immunised with HLA-DR4 positive lymphocytes bind specifically to Proteus (Ebringer et al, 1985). Amino acid sequence homologies have been identified between the 'EQ/KRRAA' motif present in RA HLA-susceptibility antigens and the 'ESRRAL' amino acid sequence present in P. mirabilis haemolysins (Ebringer et al, 1992).…”
Section: Introductionmentioning
confidence: 97%
“… Elevated serum levels of P. mirabilis specific cross-reactive antibodies have frequently been reported in individuals suffering from RA[ 4 5 6 7 8 9 ] P. mirabilis antibodies from RA patients have cytopathic effects on joint tissue possessing P. mirabilis cross-reactive antibodies[ 10 ] P. mirabilis infections have been frequently reported in urine samples from patients with RA[ 11 ] Sera from rabbits immunized with HLA-DR4 positive lymphocytes bind specifically to Proteus [ 12 ] Amino acid sequence homologies have been identified between the “EQ/KRRAA” motif present in RA HLA-susceptibility antigens and the “ESRRAL” amino acid sequence present in P. mirabilis hemolysins[ 13 ] A further sequence homology between the “LRREI” sequence of type XI collagen (present in joint cartilage) and the “IRRET” motif present in P. mirabilis urease enzyme has also been reported. [ 14 ] …”
Section: Introductionmentioning
confidence: 99%
“…P. mirabilis antibodies from RA patients have cytopathic effects on joint tissue possessing P. mirabilis cross-reactive antibodies[ 10 ]…”
Section: Introductionmentioning
confidence: 99%
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“…Furthermore, evidence exists which indicate that in RA Proteus infections usually occur in subclinical or asymptomatic forms [40]. …”
Section: Evidence For Associated or Preceding Bacterial Infectionsmentioning
confidence: 99%