Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD)

Rheumatoid arthritis-associated lung disease

“…Both rheumatoid factor and anti-CCP have been linked to the development of ILD, particularly when present in high titres [4,[17][18][19][20][21]. Anti-CCP antibodies have also been associated with the development of airway disease [2]. There is growing evidence that rheumatoid arthritis begins in the lungs, a theory supported by a subgroup of patients who are anti-CCP positive with lung disease but have no articular manifestations [22,23].…”

“…2) [31]. Studies have shown there is good correlation between HRCT and surgical lung biopsy in patients with idiopathic pulmonary fibrosis (IPF), and surgical lung biopsy may not be necessary in patients with a HRCT scan demonstrating classic findings for UIP [2,29,32]. NSIP is the second most common pattern, occurring in ∼11-32% of patients [28].…”

“…Cyclophosphamide and azathioprine have been used with varying success [38,39], and there are a few case reports of ILD regression following cyclosporine treatment [40,41]. More recently, several small studies have demonstrated stabilisation and/ or improvement in symptoms, imaging and PFTs with use of mycophenolate [2,42,43]. A review of 125 patients with connective tissue disease associated-ILD (18 of which had rheumatoid arthritis) found that mycophenolate was associated with improvement in PFTs in patients with non-UIP patterns of ILD, and led to stabilisation among those with UIP [43].…”

“…The majority of respiratory manifestations occur within the first 5 years of disease [1]. Respiratory symptoms may precede onset of articular symptoms in 10-20% of cases [2]. However, they may be masked by poor functional status from joint disease or chronic inflammation.…”

Cistinės Fibrozės Artropatijos: Klinikinis Atvejis

“…Manoma, jog CF epizodinis artritas yra lengva reumatoidinio artrito forma, kuri gali pereiti į tikrąjį reumatoidinį artritą [9]. Kliniškai tai pasireiškia simetriniu poliartritu su mazgeliais, sąnarių erozijomis.…”