Rheumatoid arthritis: rheumatoid factors, immunecomplexes, and C‐reactive protein are raised shortly after the onset of symptoms

Jones, Valerie E.; Jacoby, R K

doi:10.1002/anr.1780320129

Arthritis & Rheumatism

1989

DOI: 10.1002/anr.1780320129

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Rheumatoid arthritis: rheumatoid factors, immunecomplexes, and C‐reactive protein are raised shortly after the onset of symptoms

Valerie E. Jones

R K Jacoby

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Cited by 4 publications

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Rheumatoid factor, HLA–DR4, and allelic variants of DRB1 in women with recent‐onset rheumatoid arthritis

et al. 1994

Arthritis & Rheumatism

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Objective. To examine the relationship of rheumatoid factor (RF) to HLA-DR4 and alleles of DRBl in women with recent-onset rheumatoid arthritis (RA).Methods. Incident cases of RA were identified as part of a prospective, population-based cas-ontrol study. HLA typing was completed for 246 cases meeting criteria for definite or classic RA.Results. One hundred thirty-six patients (55%) were positive for DR4, and 130 (53%) were RF positive. DR4 was found to be strongly associated with seropositivity (odds ratio 4.1, P < 0.0001). Patients with a shorter interval from RA onset to RF testing had a higher frequency of seropositivity than those with a longer interval (518 months 60%, >18 months 33%). Further analysis of patients who had RF testing within 18 months of RA onset showed that the frequency of seropositivity was significantly greater among DR4-positive patients who had the shared sequence stretch of DRPl associated with RA susceptibility (76% RF positive) than among DR1-positive patients who had this sequence (45% RF positive) (odds ratio 3.8, P = 0.01).Moreover, the frequency of seropositivity among DR1-

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Rheumatoid factor, HLA–DR4, and allelic variants of DRB1 in women with recent‐onset rheumatoid arthritis

et al. 1994

Arthritis & Rheumatism

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Relationship between leukotriene B4 and immunological parameters in rheumatoid synovial fluids

et al. 1991

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Leukotriene B4 (LTB4) was measured in synovial fluid from 20 patients with rheumatoid arthritis and 15 patients with osteoarthritis. The level of LTB4 was significantly higher in synovial fluid from rheumatoid arthritis patients as compared with synovial fluid from osteoarthritis patients. LTB4 levels also significantly correlated with cell numbers, rheumatoid factor, and immune complexes in synovial fluid from rheumatoid arthritis patients. There was an inverse correlation between LTB4 levels and complement components. The high-pressure liquid chromatography peak of immunoreactivity extracted from the synovial fluid occurred at a retention volume identical to that of authentic LTB4. These results suggest that the increased level of this mediator in synovial fluid may contribute to perpetuation of inflammation and tissue destruction in rheumatoid arthritis.

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Occurrence of two germline-related rheumatoid factor idiotypes in rheumatoid arthritis and in non-rheumatoid seropositive individuals

Kouri

Crowley

Aho

et al. 1990

Clinical and Experimental Immunology

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SUMMARYHuman rheumatoid factor (RF) paraproteins express two distinct light cbain cross-reactive idiotypes defined by the monoclonal antibodies 17.109 and 6B6.6, These geniiline gene-related cross-reactive idiotypes arc both carried on I-',., hght chains and are each present on about one-third of IgM RF paraproteins. We assessed the degree to which these idiotypes are represented in polyclonal RFs, We used rheumatoid arthritis (RA) and non-RA RF-positivc sera selected from a large cross-sectional population study (the Mini-Finland Health Survey), and sera from a community-based follow-up study of recent-onset RA patients from Heinola. Finland. In the Mini-Finland Health Survey. elevated levels of the 17.109 RF idiotype were seen in sera of 13'^ ofthe RA and \9% ofthe non-RA group; 6B6,6 RF was seen in 26% ofthc RA and 28"/i) ofthe non-RA group. In sera ofthe Heinola follow-up study, 17.109 RF was seen in 12% initially, but in only 3' >a at 8 years. Similarly. 6B6.6 RF was detected in 25% initially, but in only 7% at 8 years. Ten sera positive for RF prior to the onset of elinical R A were identified from individuals of a second large population study from Finland (North Karelia project); two of these sera exhibited the 6B6,6 idiotype; none exhibited the 17.109 idiotype. The data are consistent with the concept that these germline gene-related cross-reactive RF idiotypes occur frequently in the polyclonal RF of non-RA as well as RA sera, and that in RA the idiotypes may sometimes be reduced or lost as a consequence of somatic diversification of the RK through somatic mutation, usage of new germline genes, or both.

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Rheumatoid arthritis: rheumatoid factors, immunecomplexes, and C‐reactive protein are raised shortly after the onset of symptoms

Cited by 4 publications

References 7 publications

Rheumatoid factor, HLA–DR4, and allelic variants of DRB1 in women with recent‐onset rheumatoid arthritis

Rheumatoid factor, HLA–DR4, and allelic variants of DRB1 in women with recent‐onset rheumatoid arthritis

Relationship between leukotriene B4 and immunological parameters in rheumatoid synovial fluids

Occurrence of two germline-related rheumatoid factor idiotypes in rheumatoid arthritis and in non-rheumatoid seropositive individuals

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