Rheumatoid factor-positive synovitis in a patient with C3 deficiency

Clinical characteristics and genotype-phenotype correlations in C3 deficiency

“…2 However, no definite genotype-phenotype correlations have been established to date, possibly because of the extremely low prevalence of the disorder. In the present study, we investigated the clinical features of our 4 cases [3][4][5][6] of C3 deficiency and reviewed previously reported cases to clarify the genotype-phenotype correlations in this disorder. We searched for English and Japanese articles describing C3 deficiency in PubMed, Ovid, and Google Scholar from 1972 (first reported year of C3 deficiency) to December 2014.…”

“…Three days after epicutaneous sensitization with the hapten oxazolone, mice were challenged by epicutaneous oxazolone application, and the prominent skin swelling reaction induced as a result is accompanied by an influx of inflammatory cells into the dermis consisting of mononuclear cells, eosinophils, and neutrophils, indicating a mixed T H 1-/T H 2-type inflammatory response and mild hyperkeratosis. Treatment with DNAzymes formulated in a water-in-oil-in-water emulsion, specifically developed for penetration enhancement and DNAzyme protection, 6,7 was performed by topical application.…”