Rheumatoid factors in patients with silicosis with round nodular fibrosis of the lung in the absence of rheumatoid arthritis. With a note on the failure to induce such factors in animals

Schroeder, W. C.; McEwen, Currier

doi:10.1002/art.1780050103

Cited by 25 publications

(2 citation statements)

References 27 publications

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“…Further evidence came from studies of silicotic workers. Workers with abnormal chest radiographs but without rheumatoid arthritis had high rates of positive serological findings, of rheumatoid factor in coal miners,8 and of antinuclear antibodies in sandblasters 9. Medical records of silicotic workers in Michigan, USA10 suggested more cases of rheumatoid arthritis than in the general population but the criteria for diagnosis differed in the case and comparison series.…”

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confidence: 98%

Rheumatoid arthritis in workers exposed to silica in the pottery industry

Turner

Cherry²

2000

Occup Environ Med

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Objective-To investigate the relation between rheumatoid arthritis and occupational exposure to silica in pottery and related industries. Methods-Medical records of 8325 men and women born 1916-45 and employed in pottery, refractory material (aluminosilicate or silica), and sandstone industries were examined to identify cases of rheumatoid arthritis. Medical and employment histories were extracted for cases and matched referents. Indices of duration, cumulative exposure, and mean silica concentration were compiled. Conditional logistic regression was used to investigate the relation between rheumatoid arthritis and indices of exposure, having allowed for potential confounders of smoking, employment in the coal mining industry, and number of pregnancies. Results-58 Cases of rheumatoid arthritis (43 men, 15 women) were identified. Cases had significantly shorter duration of exposure than referents. There was no significant diVerence between cases and referents in mean silica concentration. Men who had worked in the coal mining industry were particularly at risk (odds ratio 5.36, 95% confidence interval 1.92 to 15.03). Conclusion-There was no evidence of increased risk of developing rheumatoid arthritis after occupational exposure to silica at mean exposures within the current United Kingdom exposure limits. (Occup Environ Med 2000;57:443-447)

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confidence: 98%

Rheumatoid arthritis in workers exposed to silica in the pottery industry

Turner

Cherry²

2000

Occup Environ Med

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“…It is known that rheumatoid factor, i.e., IgM antibody for slightly denatured serum IgG, is produced in silicosis human beings (124) and experimental animals (43), and that this is the most likely explanation for the Scheel phenomenon. In human disease the incidence of rheumatoid factor would not appear great enough to produce the hyaline material in silicotic lesions.…”

Section: Physical Agentsmentioning

confidence: 99%

Immunological Reactions to Inhaled Physical and Chemical Agents

Burrell

1977

Comprehensive Physiology

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The sections in this article are: Classification of Types of Immune Injury Type I: Reagin‐Dependent Reactions Type II : Cytotoxic Reactions Type III : Immune Complex Disposition Reactions Type IV : Cell‐Mediated or Delayed Hypersensitivity Reactions Nonspecific Complement Activation Inhalants Physical Agents Chemical Agents Antigens of Plant Origin Antigens of Animal Origin Immunosuppressive Inhalants Halothane and Other Inhalant Anesthetics Cigarette Smoke

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Silica and Silica Compounds

Marrocco,

Dy,

Ortiz

et al. 2023

Patty's Toxicology

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Crystalline silica is one of the most abundant minerals on Earth. More than 230 million individuals around the world, and more than 2 million workers in the United States, predominantly in construction and mining occupations, are exposed to silica every year. Inhalation of crystalline silica leads to the development of silicosis, a progressive pneumoconiosis characterized by chronic lung inflammation and fibrosis, for which no specific therapy is available. Silicosis is also associated with increased risk of tuberculosis, lung cancer, chronic obstructive pulmonary disease (COPD), kidney disease, and autoimmune disease. These health risks remain elevated even after silica exposure has ceased. Although preventive measures have decreased the mortality attributable to silica exposure in the past decade, this occupational lung disease still kills about 100 people every year in the United States, according to the National Institute for Occupational Safety and Health (NIOSH). Between 1999 and 2013, silicosis was the underlying or contributing cause of death for about 2000 people, and 300 deaths occurred each year between 1991 and 1995, while it decreased to about 100 per year in 2012 and 2013. Data from NIOSH show that a large number of workers are at increased risk for silicosis because of exposure to silica levels that exceed current regulatory standards. Therefore, regulatory agencies have been forced to further reduce the permissible exposure levels (PEL) to 25 μg/m 3 (micrograms of silica per cubic meter of air) over an 8‐h shift, to improve prophylaxis. Despite these efforts, silicosis remains a global health threat.

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Rheumatoid factors in patients with silicosis with round nodular fibrosis of the lung in the absence of rheumatoid arthritis. With a note on the failure to induce such factors in animals

Cited by 25 publications

References 27 publications

Rheumatoid arthritis in workers exposed to silica in the pottery industry

Rheumatoid arthritis in workers exposed to silica in the pottery industry

Immunological Reactions to Inhaled Physical and Chemical Agents

Silica and Silica Compounds

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