Rheumatoid neutrophilic dermatitis in a woman with seronegative rheumatoid arthritis

Brown, Timothy S.; Fearneyhough, Paul; Burruss, Jyoti B.; Callen, Jeffrey P.

doi:10.1067/mjd.2001.119031

Cited by 46 publications

(26 citation statements)

References 10 publications

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“…208 Rheumatoid neutrophilic dermatitis, however, has been described as erythematous papules, plaques, nodules, and urticarial wheals that occur over the extremities and trunk. [212][213][214] Patients with rheumatoid neutrophilic dermatitis are prone to severe and disabling RA. Although initially described in RA with high-titer RF, several reports of seronegative RA presenting with rheumatoid neutrophilic dermatitis have been published.…”

Section: Felty Syndromementioning

confidence: 99%

Rheumatoid arthritis: A review of the cutaneous manifestations

Sayah

English

2005

Journal of the American Academy of Dermatology

220

147

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Section: Felty Syndromementioning

confidence: 99%

Rheumatoid arthritis: A review of the cutaneous manifestations

Sayah

English

2005

Journal of the American Academy of Dermatology

220

147

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“…[8][9][10][11][12][13][14][15] Spongiosis, intraepidermal vesiculation, subepidermal edema, and papillary dermal neutrophilic microabscesses also may be present. 9,11,12 Our case manifested with a symmetric eruption of pruritic grouped vesicles and tense bullae on the extremities.…”

Section: Discussionmentioning

confidence: 99%

“…Other possible treatments include topical steroids, sulfamethoxypyridamine, hydroxychloroquine, colchicine, cyclophosphamide, and etretinate. [6][7][8][9][10][11][12][13][14][15] Considering the role of extremely high RF titer and IgA gammopathy in the patient's condition is interesting. High RF titer frequently is associated with progressive RA and indicates a worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14][15] RND generally manifests as nontender, erythematous, sometimes urticaria-like, papules, plaques, or nodules, symmetrically distributed on the joints and the extensor surface of the extremities, trunk, and neck. [6][7][8][9][10][11][12][13][14][15] Tiny pustules occasionally also are associated with the condition. 11,12 Lowe et al 9 presented the only report to date of RND displaying vesiculopapular lesions.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5] Recently, a new form of ND, rheumatoid ND (RND), has been reported in patients with severe RA. [6][7][8][9][10][11][12][13][14][15] This article describes a case of RND manifesting mainly with clusters of vesicles and tense bullae, clinically mimicking dermatitis herpetiformis (DH).…”

mentioning

confidence: 99%

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A bullous neutrophilic dermatosis in a patient with severe rheumatoid arthritis and monoclonal IgA gammopathy

Yang

Hong

2004

Journal of the American Academy of Dermatology

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Vascular Inflammation (Vasculitis) in Sweet Syndrome

Malone

Slone²,

Wills-Frank³

et al. 2002

Arch Dermatol

Self Cite

127

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Background: Sweet syndrome is characterized by painful, erythematous plaques of rapid onset accompanied by fever. Absence of vasculitis is a histologic criterion for diagnosis. However, recent reports suggest that vasculitis should not exclude the diagnosis. We hypothesized that vasculitis can occur in Sweet syndrome and that it represents an epiphenomenon rather than a primary immune-mediated process.Design: Skin biopsy specimens from patients with Sweet syndrome were reviewed to determine the prevalence of vasculitis. The clinicopathologic features of cases with vasculitis were evaluated for statistically significant associations. Specimens with vasculitis underwent immunofluorescence staining.Setting: University department of dermatology, university hospital, and private practice.Patients: Medical records and biopsy specimens of 21 patients meeting diagnostic criteria for Sweet syndrome were reviewed. Interventions: None.Results: The prevalence of vasculitis was 29% (6 of 21 patients). There was a significant association of vasculitis with lesions of longer duration (P=.02). Vascular immunoglobulin and complement could not be demonstrated in cases of Sweet syndrome with vasculitis.Conclusions: Vasculitis is not a primary, immunemediated process in Sweet syndrome but occurs secondary to noxious products released from neutrophils. Blood vessels in lesions of longer duration are more likely to develop vasculitis than those of shorter duration because of prolonged exposure to noxious metabolites. Vasculitis does not exclude a diagnosis of Sweet syndrome.

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Rheumatoid neutrophilic dermatitis in a woman with seronegative rheumatoid arthritis

Cited by 46 publications

References 10 publications

Rheumatoid arthritis: A review of the cutaneous manifestations

Rheumatoid arthritis: A review of the cutaneous manifestations

A bullous neutrophilic dermatosis in a patient with severe rheumatoid arthritis and monoclonal IgA gammopathy

Vascular Inflammation (Vasculitis) in Sweet Syndrome

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