Rheumatologic Diseases as Paraneoplastic Syndromes - A Paradigmatic Case

de, Figueiredo Inês Rego; Vieira, Alves Rita; Guerreiro, Castro Sara; Filipa, Lourenço; Margarida, Antunes Ana; Gruner, Heidi; Panarra, António

doi:10.23937/2469-5726/1510067

Cited by 2 publications

(4 citation statements)

References 17 publications

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“…They should not arise from direct tumor invasion or compression, and usually improve with treatment of the underlying malignancy [ 3 , 4 ]. Paraneoplastic arthritis itself is an inflammatory polyarthritis which may be seronegative [ 5 ]. It has a male predominance, with an average age of onset of 54 years [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Paraneoplastic arthritis itself is an inflammatory polyarthritis which may be seronegative [ 5 ]. It has a male predominance, with an average age of onset of 54 years [ 5 ]. The arthritis is typically asymmetrical, commonly affecting the lower extremity joints, and may occur about 8–12 months prior to malignancy development [ 1 , 3 – 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has a male predominance, with an average age of onset of 54 years [ 5 ]. The arthritis is typically asymmetrical, commonly affecting the lower extremity joints, and may occur about 8–12 months prior to malignancy development [ 1 , 3 – 5 ]. It is usually poorly responsive to the standard therapy of DMARDs, corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDs) [ 1 , 3 – 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…The arthritis is typically asymmetrical, commonly affecting the lower extremity joints, and may occur about 8–12 months prior to malignancy development [ 1 , 3 – 5 ]. It is usually poorly responsive to the standard therapy of DMARDs, corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDs) [ 1 , 3 – 5 ]. Malignancies associated with paraneoplastic arthritis include lung, breast, ovarian, laryngeal and gastrointestinal tumors [ 2 – 4 ].…”

Section: Discussionmentioning

confidence: 99%

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Arthritis as an initial presentation of malignancy: two case reports

et al. 2021

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Background Arthritis is rarely reported as a paraneoplastic manifestation of occult malignancy. We report herein two cases of paraneoplastic arthritis due to occult malignancy. Case 1 The patient was a 65-year-old woman of asian descent who was a former smoker with a history of spine surgery performed for L4/L5 degenerative disc disease. She presented with a 1-month history of oligoarthritis affecting both ankle joints and early morning stiffness of about 3 hours. Laboratory tests were positive for antinuclear antibody at a titer of 1:320 (speckled) but negative for rheumatoid factor. She was treated for seronegative spondyloarthritis and started on prednisolone without much improvement. A routine chest radiograph incidentally revealed a right lung mass which was found to be adenocarcinoma of the lung. She was treated with gefitinib and her arthritis resolved. Case 2 The patient was a 64-year-old woman of asian descent, nonsmoker, who presented with a chief complaint of asymmetrical polyarthritis involving her right wrist, second and third metacarpophalangeal joints, and first to fifth proximal interphalangeal joints. She was treated for seronegative rheumatoid arthritis (RA) and started on sulfasalazine, with poor clinical response. Six months later, she developed abdominal pain which was diagnosed as ovarian carcinoma by laparotomy. Her arthritis resolved following treatment of her malignancy with chemotherapy. Conclusion In summary, paraneoplastic arthritis usually presents in an atypical manner and responds poorly to disease-modifying antirheumatic drugs. Accordingly, we recommend screening for occult malignancy in patients presenting with atypical arthritis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Arthritis as an initial presentation of malignancy: two case reports

et al. 2021

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Axial spondyloarthritis as a paraneoplastic syndrome (clinical case)

Akulinushkina,

Iskhakova,

Yakupova

2024

Medicinskij alfavit

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The article reports the problems of rheumatic disease as paraneoplastic syndrome. It includes the description of the clinical case of axial spondyloarthritis as paraneoplastic syndrome related to the neuroendocrine tumor of the duodenum. In this case, axial spondyloarthritis was characterized by rapid involvement of peripheral and axial symptoms, high acute phase reactants, resistance to drug therapy and reduction of clinical and laboratory symptoms after treatment for neuroendocrine tumor. In differential diagnostics of and paraneoplastic rheumatic disease, it is necessary to pay attention for the time of occurrence of rheumatic symptoms, clinical symptoms before and after surgical and non-surgical treatment for cancer, response to drug therapy, family cancer anamnesis, exposure to carcinogens, previous immunosuppressive therapy, as well as severity of general constitutional symptoms, atypical manifestations of rheumatic disease, age of disease debut over 50 years.

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Rheumatologic Diseases as Paraneoplastic Syndromes - A Paradigmatic Case

Cited by 2 publications

References 17 publications

Arthritis as an initial presentation of malignancy: two case reports

Arthritis as an initial presentation of malignancy: two case reports

Axial spondyloarthritis as a paraneoplastic syndrome (clinical case)

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