Rheumatology and Long COVID: lessons from the study of fibromyalgia

Clauw, Daniel J.; Calabrese, Leonard H.

doi:10.1136/ard-2023-224250

Cited by 12 publications

(7 citation statements)

References 28 publications

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“…Cluster 1 encompasses a significantly higher number of patients suffering from FM in comparison to Cluster 2 (PV < 0.001 for SSS and PV = 0.053 for WPI): 25 (43.1%) vs. 12 (21.4%), respectively, with a high rate (32.7% vs. 16%, respectively) of new diagnosis appearing simultaneously surrounding developing Long COVID syndrome. This observation strengthens the connection between Long COVID and FM, which is the focus of extensive research, indicating shared pathophysiology, risk factors, and similar manifestations [47].…”

Section: Discussionsupporting

confidence: 80%

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Long COVID-19 Enigma: Unmasking the Role of Distinctive Personality Profiles as Risk Factors

Amsterdam,

Kupershmidt,

Avinir

et al. 2024

JCM

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Background: The COVID-19 (Coronavirus disease 2019) pandemic has prompted extensive research into lingering effects, especially in ‘Long COVID’ patients. Despite exploration, contributing factors remain elusive; Objective: This study explores the potential link between distinctive personality profiles, particularly type D personality, and an increased risk of Long COVID; Methods: A retrospective cross-sectional study at Tel-Aviv Sourasky Medical Center’s Post-COVID clinic analyzed data from 373 Long COVID patients through comprehensive questionnaires covering Long COVID syndrome, Fibromyalgia criteria, personality assessments, social support, and subjective evaluations of cognitive decline, health and life quality. In total, 116 out of 373 patients completed the questionnaire, yielding a 31% participation rate; Results: Cluster analysis revealed two groups, with Cluster 1 (N = 58) exhibiting Type D personality traits while Cluster 2 (N = 56) not meeting criteria for Type D personality. In comparison to Cluster 2, Cluster 1 patients reported heightened anxiety, depression, reduced social support, increased pain symptoms, manifestations of fibromyalgia, cognitive decline, and poor sleep quality, contributing to a diminished quality-of-life perception; Conclusions: findings highlight diverse personality profiles among Long COVID patients, emphasizing the need for tailored care. This approach shows potential for improving Long COVID patient care, aligning with the evolving personalized medicine paradigm.

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Section: Discussionsupporting

confidence: 80%

“…The clinical and possible pathogenetic overlap between Long COVID and FM is an evolving concept that has attracted significant interest in the current literature [47,48].…”

Section: Discussionmentioning

confidence: 99%

Long COVID-19 Enigma: Unmasking the Role of Distinctive Personality Profiles as Risk Factors

Amsterdam,

Kupershmidt,

Avinir

et al. 2024

JCM

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“…This dysfunction leads to abnormal production of reactive oxygen species (ROS) with possible induction of chronic pain [ 146 , 147 ]. In summary, it can be speculated that the close relationship between long COVID and FM may be an important clue to clarify aspects of FM [ 148 ].…”

Section: The Role Of Pathogensmentioning

confidence: 99%

Inflammation, Autoimmunity, and Infection in Fibromyalgia: A Narrative Review

Paroli,

Gioia,

Accapezzato

et al. 2024

IJMS

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Fibromyalgia (FM) is a chronic disease characterized by widespread musculoskeletal pain of unknown etiology. The condition is commonly associated with other symptoms, including fatigue, sleep disturbances, cognitive impairment, and depression. For this reason, FM is also referred to as FM syndrome. The nature of the pain is defined as nociplastic according to the latest international classification and is characterized by altered nervous sensitization both centrally and peripherally. Psychosocial conditions have traditionally been considered critical in the genesis of FM. However, recent studies in animal models and humans have provided new evidence in favor of an inflammatory and/or autoimmune pathogenesis. In support of this hypothesis are epidemiological data of an increased female prevalence, similar to that of autoimmune diseases, and the frequent association with immune-mediated inflammatory disorders. In addition, the observation of an increased incidence of this condition during long COVID revived the hypothesis of an infectious pathogenesis. This narrative review will, therefore, discuss the evidence supporting the immune-mediated pathogenesis of FM in light of the most current data available in the literature.

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“…A subset of patients with FM had elevated levels of anti-satellite glial cell antibodies, but this was not associated with cytokine release or with systemic inflammation (61). It has been suggested that the nociplastic pain characteristic of FM, ME/CFS, and long COVID may share similar glial brain activation pathways (62,63).…”

Section: Similar Pathophysiologic Pathways (Table 3)mentioning

confidence: 99%

Applying Lessons From Rheumatology to Better Understand Long COVID

Goldenberg

2023

Arthritis Care & Research

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Long COVID can sometimes be attributed to organ damage and well‐characterized pathophysiology, but more often there is no evidence of organ damage or abnormal biomarkers. This is most evident in patients with mild to moderate initial SARS‐CoV‐2 infection who were not hospitalized. Their persistent symptoms are strikingly similar to those of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), including fatigue, post exertional malaise, myalgias/arthralgias, sleep and cognitive disturbances in 50‐100% of cases.Analogous pathophysiologic pathways in FM, ME/CFS and long COVID include host‐microbial interactions in the absence of direct tissue invasion, an absence of systemic autoimmunity, but evidence for immune dysregulation, as well as autonomic, peripheral, and central nervous system dysfunction. Current treatment of long COVID has been based on multidisciplinary management recommended for FM and ME/CFS but has been formalized and widely available by funding for nation‐wide long COVID clinics. Long COVID and its treatment should be distinguished by the presence or absence of organ damage. The acknowledged role of patient engagement in research and open dialogue regarding work and disability noted in long COVID may have meaningful impact on patients with FM and ME/CFS. Hopefully, advances in long COVID basic research will aid in understanding FM and ME/CFS and rheumatologists should be involved in such research and patient care.image

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Rheumatology and Long COVID: lessons from the study of fibromyalgia

Cited by 12 publications

References 28 publications

Long COVID-19 Enigma: Unmasking the Role of Distinctive Personality Profiles as Risk Factors

Long COVID-19 Enigma: Unmasking the Role of Distinctive Personality Profiles as Risk Factors

Inflammation, Autoimmunity, and Infection in Fibromyalgia: A Narrative Review

Applying Lessons From Rheumatology to Better Understand Long COVID

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