rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice

Li, Le; Wang, Huan; Pang, Shucai; Wang, Liangshun; Fan, Zhengkai; Cheng, Mengqi; Yang, Shufen; Banda, Joshua; Qi, Hui; Lv, Fangyi; Fan, Haibing; Huang, Tongzhou; Xiao-bi, Zhang; Wang, Xiaojie

doi:10.1016/j.jbc.2023.105127

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…Recombinant human fibroblast growth factor-21, in an in vitro and in vivo study, promoted corneal epithelial wound healing by reducing the levels of pro-inflammatory markers, including TNF-α, IL-6, IL-1β, the monocyte chemoattractant protein-1, interferon gamma, MMP-2, and MMP-9, and enhancing those of antioxidative enzymes, such as SOD-1, in both diabetic mouse corneal epithelium and human corneal epithelial cells treated with high glucose [178].…”

Section: Counteracting Oxidative Stress and Inflammationmentioning

confidence: 98%

“…Table 1 provides a summarizing overview of the experimental molecules showing promise in counteracting diabetic keratopathy, with a focus on their chemical structure, mechanism of action, and molecular targets. antioxidant enzyme expression such as that of SOD-1 [178] Table Abbreviations. AGEs: advanced glycated end products; Akt: Ak strain transforming (also known as protein kinase B); ALA: α-lipoic acid; AMPK: adenosine monophosphate-activated protein kinase; DED: dry eye disease; DMF: dimethyl fumarate; GLY: glycyrrhizin; GPx3: glutathione peroxidase 3; HMGB1: highmobility group protein B1; HO-1: heme oxygenase-1; HPMC: hydroxypropyl methylcellulose; IGFR-1: insulinlike growth factor receptor 1; IL-1β: interleukin beta 1; miRNA: micro RNA; Mito-Q: mitoquinone; NAC: N-acetylcysteine; NF-kB: nuclear factor 'kappa-light-chain-enhancer' of activated B cells; NLRP3: nucleotidebinding domain, leucine-rich-containing family, pyrin domain-containing-3; NMN: nicotinamide mononucleotide; NOX: nicotinamide adenine dinucleotide phosphate oxidase; Nrf-2: nuclear factor erythroid-derived 2-related factor 2; PEDF: pigment epithelium-derived factor; PPARγ: peroxisome proliferator-activated receptor gamma; RAGE: receptor of advanced glycated end products; rhFGF-21: recombinant human fibroblast growth factor-21; ROS: reactive oxygen species; SIRT1: sirtuin 1; SOD: superoxide dismutase; TLR: toll-like receptor; TNF-α: tumor necrosis factor alpha.…”

Section: Counteracting Oxidative Stress and Inflammationmentioning

confidence: 99%

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Diabetic Keratopathy: Redox Signaling Pathways and Therapeutic Prospects

Buonfiglio,

Wasielica-Poslednik,

Pfeiffer

et al. 2024

Antioxidants

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Diabetes mellitus, the most prevalent endocrine disorder, not only impacts the retina but also significantly involves the ocular surface. Diabetes contributes to the development of dry eye disease and induces morphological and functional corneal alterations, particularly affecting nerves and epithelial cells. These changes manifest as epithelial defects, reduced sensitivity, and delayed wound healing, collectively encapsulated in the context of diabetic keratopathy. In advanced stages of this condition, the progression to corneal ulcers and scarring further unfolds, eventually leading to corneal opacities. This critical complication hampers vision and carries the potential for irreversible visual loss. The primary objective of this review article is to offer a comprehensive overview of the pathomechanisms underlying diabetic keratopathy. Emphasis is placed on exploring the redox molecular pathways responsible for the aberrant structural changes observed in the cornea and tear film during diabetes. Additionally, we provide insights into the latest experimental findings concerning potential treatments targeting oxidative stress. This endeavor aims to enhance our understanding of the intricate interplay between diabetes and ocular complications, offering valuable perspectives for future therapeutic interventions.

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Section: Counteracting Oxidative Stress and Inflammationmentioning

confidence: 98%

Section: Counteracting Oxidative Stress and Inflammationmentioning

confidence: 99%

Diabetic Keratopathy: Redox Signaling Pathways and Therapeutic Prospects

Buonfiglio,

Wasielica-Poslednik,

Pfeiffer

et al. 2024

Antioxidants

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“…RhFGF-21 also inhibits excessive production of reactive oxygen species (ROS) and alleviates oxidative stress induced by hyperglycemia in corneal epithelial cells. Therefore, the application of drugs containing FGF-21 may be a potential treatment method for DK ( 125 , 126 ).…”

Section: Growth Factors Involved In Repair Mechanismsmentioning

confidence: 99%

Elucidating the mechanism of corneal epithelial cell repair: unraveling the impact of growth factors

Gong,

Ding,

Hao

et al. 2024

Front. Med.

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The repair mechanism for corneal epithelial cell injuries encompasses migration, proliferation, and differentiation of corneal epithelial cells, and extracellular matrix remodeling of the stromal structural integrity. Furthermore, it involves the consequential impact of corneal limbal stem cells (LSCs). In recent years, as our comprehension of the mediating mechanisms underlying corneal epithelial injury repair has advanced, it has become increasingly apparent that growth factors play a pivotal role in this intricate process. These growth factors actively contribute to the restoration of corneal epithelial injuries by orchestrating responses and facilitating specific interactions at targeted sites. This article systematically summarizes the role of growth factors in corneal epithelial cell injury repair by searching relevant literature in recent years, and explores the limitations of current literature search, providing a certain scientific basis for subsequent basic research and clinical applications.

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“…It has been found that rhFGF21 not only inhibits macrophage-mediated inflammation by activating the Nrf2-mediated anti-oxidant response and suppressing the NF-κB signaling pathway but also reduces the levels of pro-inflammatory cytokines in diabetic mouse and human corneal epithelial cells ( 134 ). Additionally, rhFGF21 treatment decreases reactive oxygen species production, boosts anti-inflammatory molecules like IL-10 and SOD-1, and reduces the release of inflammatory mediators and matrix metalloproteinases, indicating its potential protective role in healing diabetic corneal epithelial cells through enhanced antioxidant capacity ( 135 ).…”

Section: Potential Strategies For Regulating Macrophage Function By M...mentioning

confidence: 99%

Fibroblast growth factor signaling in macrophage polarization: impact on health and diseases

Shen,

Li,

Zhao

2024

Front. Immunol.

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Fibroblast growth factors (FGFs) are a versatile family of peptide growth factors that are involved in various biological functions, including cell growth and differentiation, embryonic development, angiogenesis, and metabolism. Abnormal FGF/FGF receptor (FGFR) signaling has been implicated in the pathogenesis of multiple diseases such as cancer, metabolic diseases, and inflammatory diseases. It is worth noting that macrophage polarization, which involves distinct functional phenotypes, plays a crucial role in tissue repair, homeostasis maintenance, and immune responses. Recent evidence suggests that FGF/FGFR signaling closely participates in the polarization of macrophages, indicating that they could be potential targets for therapeutic manipulation of diseases associated with dysfunctional macrophages. In this article, we provide an overview of the structure, function, and downstream regulatory pathways of FGFs, as well as crosstalk between FGF signaling and macrophage polarization. Additionally, we summarize the potential application of harnessing FGF signaling to modulate macrophage polarization.

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rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice

Cited by 7 publications

References 34 publications

Diabetic Keratopathy: Redox Signaling Pathways and Therapeutic Prospects

Diabetic Keratopathy: Redox Signaling Pathways and Therapeutic Prospects

Elucidating the mechanism of corneal epithelial cell repair: unraveling the impact of growth factors

Fibroblast growth factor signaling in macrophage polarization: impact on health and diseases

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