RhIL-11 treatment normalized Th1/Th2 and T-bet/GATA-3 imbalance in in human immune thrombocytopenic purpura (ITP)

Lin, Ying; Zhou, Xiumin; Guo, Weidong; Li, Qianqian; Pan, Xiahui; Bao, Yunhua; He, Min; Zhu, Bo; Lin, Xiaoji; Jin, Limin; Yao, Rongxin

doi:10.1016/j.intimp.2016.05.002

Cited by 16 publications

(12 citation statements)

References 28 publications

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“…Data from clinical experiments and animal studies had demonstrated that IL-11 could regulate the differentiation of both T helper cells 1 (Th1) and Th17, which were the subsets of CD4 + Th cells [32, 33]. In a report, Lin et al found that the exogenous recombinant human IL-11 treatment reduced a rate of 67.7% in Th1 and T-bet levels and normalized Th1/Th2 ratios in patients with immune thrombocytopenia [34]. Another study reported that in multiple sclerosis patients, IL-11 could induce a differentiation of naive CD4 + Th cells into Th17 cells, as well as the expansion of Th17 memory cells [35].…”

Section: Discussionmentioning

confidence: 99%

Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure

Wang

et al. 2019

Mediators of Inflammation

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Background Interleukin-11 (IL-11) is an important inflammatory cytokine and has been demonstrated to participate in cardiovascular diseases. However, there have been no studies about the role of IL-11 in heart failure (HF). The present study is aimed at investigating whether IL-11 levels are associated with the cardiac prognosis in patients with HF. Methods The plasma concentrations of IL-11 were measured in 240 patients with chronic HF (CHF) and 80 control subjects without signs of significant heart disease. In addition, we prospectively followed these CHF patients to endpoints of cardiac events. Results Compared with the control group, the plasma IL-11 concentrations were significantly increased in the CHF patients and gradually increased in the New York Heart Association (NYHA) functional class II group, the NYHA functional class III group, and the NYHA functional class IV group. The receiver operating characteristic (ROC) curve revealed that the predictive role of IL-11 in HF is not as good as N-terminal B-type natriuretic peptide (BNP), although IL-11 has a certain value in predicting cardiac events. In addition, the CHF patients were divided into 3 groups according to the plasma IL-11 concentration category (low, T1; middle, T2; and high, T3). The multivariate Cox hazard analysis showed that the high plasma IL-11 concentrations were independently associated with the presence of cardiac events after adjustment for confounding factors. Furthermore, the CHF patients were divided into two groups based on the median plasma IL-11 concentrations. The Kaplan-Meier analysis revealed that the patients with high IL-11 concentrations had a higher risk of cardiac events compared with those with low IL-11 concentrations. Conclusions Higher plasma IL-11 levels significantly increase the presence of cardiac events and suggest a poor outcome; although the diagnostic value of IL-11 in CHF is not as good as BNP, there is a certain value in predicting cardiac events in CHF.

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Section: Discussionmentioning

confidence: 99%

Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure

Wang

et al. 2019

Mediators of Inflammation

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“…In the recent first in human study, six human prostate cancer patients were treated with a site-targeted peptidomimetic drug that targets IL11Rα, which increased apoptosis in bone metastatic lesions [39]. A possible side effect of blocking IL11Rα in cancers in humans, is the effect on platelet counts, since IL11 is used as a treatment option for thrombocytopenia after chemotherapy [40]. However intriguingly, no thrombocytopenia was observed in the prostate cancer trial in men [39], or in a gastric cancer mouse model [18].…”

Section: Discussionmentioning

confidence: 99%

Therapeutically blocking interleukin-11 receptor-α enhances doxorubicin cytotoxicity in high grade type I endometrioid tumours

et al. 2017

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High grade type I endometrial cancers have poor prognosis. Interleukin (IL)11 is elevated in tumours and uterine lavage with increasing tumour grade in women. IL11 regulates cell cycle, invasion and migration and we recently demonstrated that IL11 receptor (R)α inhibition impaired low and moderate grade endometrial tumourigenesis in vivo. In this report, we hypothesized that micro-RNA(miR)-1 regulates IL11 and that IL11 promotes high grade endometrial tumour growth. We aimed to determine whether combination treatment using an anti-human IL11Rα blocking antibody (Ab) and doxorubicin chemotherapeutic impairs high grade tumour growth. MiR-1 was absent in human endometrial tumours versus human benign endometrium (n = 10/group). Transfection with miR-1 mimic restored miR-1 expression, down-regulated IL11 mRNA and impaired cell viability in grade 3-derived AN3CA human endometrial epithelial cancer cells. AN3CA cell proliferation was reduced in response to Ab and doxorubicin combination treatment versus Ab, IgG control, or doxorubicin alone. Subcutaneous xenograft tumours were established in female Balb/c athymic nude mice using AN3CA cells expressing IL11 and IL11Rα. Administration of recombinant human IL11 to mice (n = 4/group) activated IL11 downstream target, signal transducers and activators of transcription (STAT3) and significantly increased tumour growth (p < 0.05), suggesting that IL11 promotes high grade tumour growth. IL11Rα blocking Ab reduced STAT3 phosphorylation and combination treatment with doxorubicin resulted in a significant reduction in tumour growth (p < 0.05) compared to Ab, doxorubicin, or IgG control. Our data suggest that therapeutically targeting IL11Rα in combination with doxorubicin chemotherapy could inhibit high grade type I endometrioid cancer growth.

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“…Just like IFN-γ/IL-4 ratio, T-bet/GATA-3 ratio can also be considered a measure of Th1/Th2 cytokine profiles. Studies have shown that allergic asthma results from lymphocyte proliferation of allergenspecific type 2 T-helper (Th2) with over-release of Th2 cytokines such as IL-4, IL-5, IL-13 and IL-25 [19,22]. Thus, increases in T-bet/GATA-3 ratio would be beneficial for treating allergic asthma.…”

Section: Discussionmentioning

confidence: 99%

Guizhi-jia-houpu-xingzi decoction attenuates ovalbumin-induced allergic asthma via regulation of Toll-like receptor signal pathway

Zheng¹,

Gao²,

Zhao³

et al. 2017

Trop. J. Pharm Res

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Purpose: To study the effect of Guizhi-jia-houpu-xingzi (GHX) on ovalbumin-induced allergic asthma in rats. Methods: An animal model of allergic asthma (AA) in rats was established by intraperitoneal injection (ip) of ovalbumin (OVA). Thereafter, GHX (375 mg/kg) was administered orally for 7 days. Pulmonary function, inflammatory cells, immunoglobulin E (Ig) E, interleukin-4 (IL)-4 and interferon-γ (IFN)-γ in serum and bronchoalveolar lavage fluids (BALF) were determined. Furthermore, mRNA expressions of Toll-like receptors (TLRs) signal pathway was determined using real time polymerase chain reaction PCR (q-RT-PCR

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RhIL-11 treatment normalized Th1/Th2 and T-bet/GATA-3 imbalance in in human immune thrombocytopenic purpura (ITP)

Cited by 16 publications

References 28 publications

Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure

Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure

Therapeutically blocking interleukin-11 receptor-α enhances doxorubicin cytotoxicity in high grade type I endometrioid tumours

Guizhi-jia-houpu-xingzi decoction attenuates ovalbumin-induced allergic asthma via regulation of Toll-like receptor signal pathway

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