Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case report

Martínez‐Herrera, Erick; Frías-De-León, María Guadalupe; Julián-Castrejón, Angélica; Cruz-Benítez, Luis; Xicohtencatl‐Cortes, Juan; Hernández‐Castro, Rigoberto

doi:10.1186/s12879-020-05337-4

Cited by 15 publications

(15 citation statements)

References 22 publications

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“…with cases of CM, mainly after trauma or skin injuries [4,[37][38][39]. The genus Apophysomyces includes six species, but only A. elegans, A. mexicanus, A. variabilis, and A. ossiformis have been reported as causing infection in humans in both immunocompetent and immunocompromised patients [40]. Infections caused by this genus are rare, with less than 3% of all MM cases worldwide [40].…”

Section: Discussionmentioning

confidence: 99%

First Molecular Identification of Three Clinical Isolates of Fungi Causing Mucormycosis in Honduras

Ortiz¹,

Laínez-Arteaga²,

Galindo-Morales³

et al. 2022

Preprint

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Mucormycoses are rare but serious opportunistic fungal infections caused by filamentous organisms of the order Mucorales. Here we report the first molecular identification of Rhizopus oryzae (heterotypic synonym Rhizopus arrhizus), R. delemar, and Apophysomyces ossiformis as the etiological agents of three cases of severe mucormycosis in Honduras. Conventional microbiological cultures were carried out, and DNA was extracted from both clinical samples and axenic cultures. The ITS ribosomal region was amplified and sequenced. Molecular tools are suitable strategies for diagnosing and identifying Mucorales in tissues and cultures, especially in middle-income countries lacking routine diagnostic strategies.

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Section: Discussionmentioning

confidence: 99%

First Molecular Identification of Three Clinical Isolates of Fungi Causing Mucormycosis in Honduras

Ortiz¹,

Laínez-Arteaga²,

Galindo-Morales³

et al. 2022

Preprint

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“…At least four species, A. elegans, A. mexicanus A. Bonifaz et al, A. ossiforms E. Álvarez et al and A. variabilis E. Álvarez et al, are reported to cause mucormycosis (Chakrabarti et al 2010, Guarro et al 2011, Bonifaz et al 2014, Khuna et al 2019, Martínez-Herrera et al 2020. Apophysomyces species are the second common agents of mucormycosis in India (Chander et al 2021).…”

Section: Actinomucormentioning

confidence: 99%

Outline and divergence time of subkingdom Mucoromyceta: two new phyla, five new orders, six new families and seventy-three new species

Zhao

Dai

Liu

2022

Preprint

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Zygomycetes are phylogenetically early diverged, ecologically diverse, industrially valuable, agriculturally beneficial, and clinically pathogenic fungi. Although new phyla and subphyla have been constantly established to accommodate specific members and a subkingdom, Mucoromyceta, was erected to unite core zygomycetous fungi, their phylogenetic relationships have not been well resolved. Taking account of the information of monophyly and divergence time estimated from ITS and LSU rDNA sequences, the present study updates the classification framework of the subkingdom Mucoromyceta from the phylum down to the generic rank: six phyla (including two new phyla Endogonomycota and Umbelopsidomycota), eight classes, 15 orders (including five new orders Claroideoglomerales, Cunninghamellales, Lentamycetales, Phycomycetales and Syncephalastrales), 41 families (including six new families Circinellaceae, Gongronellaceae, Protomycocladaceae, Rhizomucoraceae, Syzygitaceae and Thermomucoraceae), and 121 genera. The taxonomic hierarchy was calibrated with estimated divergence times: phyla 810-639 Mya, classes 651-585 Mya, orders 570-400 Mya, and families 488- Mya. Along with this outline, 71 genera are annotated and 73 new species are described. In addition, three new combinations are proposed. In this paper, we update the taxonomic backbone of the subkingdom Mucoromyceta and reinforce its phylogeny. We also contribute numerous new taxa and enrich the diversity of Mucoromyceta.

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“…Imaging investigations aid in determining the amount of tissue invasion. Mucosal thickness, sinusitis, and bone degeneration in the nasal septa, orbit, maxilla, and mandible can all be seen on CT and MRI scans of paranasal sinus mucormycosis [13,14].…”

Section: Rhino-orbital-cerebral Mucormycosismentioning

confidence: 99%

An Overview of Mucormycosis

et al. 2022

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Mucormycosis is an angioinvasive infection caused by Zygomycosis in the order of Mucorales. It is mainly affected in immunocompromised individuals followed by risk factors such as diabetes mellitus, stem cell transplantation, organ transplantation, hematological malignancy, and more intake of steroids. Rhino-orbito-cerebral mucormycosis, pulmonary mucormycosis, cutaneous mucormycosis, gastrointestinal mucormycosis, and disseminated mucormycosis are the most common types. Moreover, it can be diagnosed to overcome this infection using the following methods such as histopathology cultures, computed axial tomography, and resonance imaging. Moreover, it can be treated with amphotericin B, the first-line drug, and posaconazole and isavuconazole are also used. The in vitro studies reveal the antifungal drugs which show the best activity against mucormycosis. The main aim of this review shows the detailed study of mucormycosis and the outcome of this infection.

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Rhino-orbital mucormycosis due to Apophysomyces ossiformis in a patient with diabetes mellitus: a case report

Cited by 15 publications

References 22 publications

First Molecular Identification of Three Clinical Isolates of Fungi Causing Mucormycosis in Honduras

First Molecular Identification of Three Clinical Isolates of Fungi Causing Mucormycosis in Honduras

Outline and divergence time of subkingdom Mucoromyceta: two new phyla, five new orders, six new families and seventy-three new species

An Overview of Mucormycosis

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