Rhinofacial Conidiobolus coronatus Infection Presenting with Nasal Enlargement

Fischer, N.; Ruef, C.; Ebnöther, C.; Bächli, Esther

doi:10.1007/s15010-008-8056-5

Cited by 38 publications

(40 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unlike the genus Basidiobolus, numerous species (around 33 species [Nie et al 2012]) have been described; some have been recovered from dead insects and mites and others are parasites of mammals, including C. coronatus (Walker et al 1992;Fischer et al 2008;Yang et al 2010), C. incongruus (Walsh et al 1994;Temple et al 2001), and C. lampragues (Vilela et al 2010;Kimura et al 2011). Because of their distinctive phenotypic features, most agree on the proper identification among the mammalian-pathogenic species that cause conidiobolomycosis.…”

Section: Hfps Of Mucorales and Entomophthoralesmentioning

confidence: 99%

Human Fungal Pathogens of Mucorales and Entomophthorales

Mendoza

Vilela

Voelz

et al. 2014

Cold Spring Harbor Perspectives in Medicine

View full text Add to dashboard Cite

In recent years, we have seen an increase in the number of immunocompromised cohorts as a result of infections and/or medical conditions, which has resulted in an increased incidence of fungal infections. Although rare, the incidence of infections caused by fungi belonging to basal fungal lineages is also continuously increasing. Basal fungal lineages diverged at an early point during the evolution of the fungal lineage, in which, in a simplified four-phylum fungal kingdom, Zygomycota and Chytridiomycota belong to the basal fungi, distinguishing them from Ascomycota and Basidiomycota. Currently there are no known human infections caused by fungi in Chytridiomycota; only Zygomycotan fungi are known to infect humans. Hence, infections caused by zygomycetes have been called zygomycosis, and the term "zygomycosis" is often used as a synonym for "mucormycosis." In the four-phylum fungal kingdom system, Zygomycota is classified mainly based on morphology, including the ability to form coenocytic (aseptated) hyphae and zygospores (sexual spores). In the Zygomycota, there are 10 known orders, two of which, the Mucorales and Entomophthorales, contain species that can infect humans, and the infection has historically been known as zygomyEditors:

show abstract

Section: Hfps Of Mucorales and Entomophthoralesmentioning

confidence: 99%

Human Fungal Pathogens of Mucorales and Entomophthorales

Mendoza

Vilela

Voelz

et al. 2014

Cold Spring Harbor Perspectives in Medicine

View full text Add to dashboard Cite

show abstract

“…Disseminated infections due to Conidiobolus spp. are extremely rare (4,11,12). One case of a fatal disseminated C. coronatus infection involving brain, lung, heart, renal allograft, and thyroid was reported in a 64-year-old male after renal transplantation.…”

Section: Vol 48 2010mentioning

confidence: 99%

“…Results of susceptibility testing may be helpful in guiding therapy but cannot predict outcome. Different schemes containing azoles, amphotericin B, trimethoprim-sulfamethoxazole, potassium iodide, terbinafine, hyperbaric oxygen, and surgical debridement have been used in various combinations with variable success (4,11,12).…”

Section: Vol 48 2010mentioning

confidence: 99%

Rhino-Orbitocerebral Zygomycosis Caused by Conidiobolus incongruus in an Immunocompromised Patient in Germany

Wüppenhorst

Lee²,

Rappold

et al. 2010

J Clin Microbiol

View full text Add to dashboard Cite

Mucorales (subphylum Mucoromycotina) are well-known agents of invasive mucormycosis, whereas Entomophthorales (subphylum Entomophthoromycotina) are rarely encountered in human diseases in temperate zones. Here we report a fatal case of invasive rhino-orbitocerebral entomophthoramycosis caused by Conidiobolus incongruus in a 78-year-old woman with myelodysplastic syndrome. CASE REPORTA 78-year-old woman with known hypoplastic myelodysplastic syndrome (MDS) with trilinear pancytopenia was admitted to our hospital for further evaluation and treatment of refractory fever. Two months earlier she had been diagnosed with hypoplastic MDS without cytogenetic alterations. Because of her good clinical presentation and her age, chemotherapy was not initiated. Other known comorbidities were arterial hypertension and non-insulin-dependent diabetes mellitus without signs of hyperglycemia. Five weeks before admission, she had developed cellulitis on the right side of the forehead and treatment with cefuroxime intravenously (i.v.) (3 doses of 1.5 g/day) had been initiated, because of an initial swab from which methicillin-sensitive Staphylococcus aureus was cultured. At the time of referral, the patient was in a reduced general state of health and she was unable to open the right eye. Hemogram showed leukocyte counts of 700/l, a hemoglobin level of 6.9 g/dl, thrombocyte counts of 2,000/l, and a C-reactive protein level of 476 mg/liter. Blood cultures remained sterile. Galactomannan and (133)-beta-D-glucan detection in serum was attempted repeatedly with negative results. However, fever persisted and antibiotic therapy was switched to piperacillintazobactam i.v. (3 doses of 4.5 g/day) and finally to imipenem i.v. (3 doses of 1 g/day). Trimethoprim-sulfamethoxazole orally (p.o.) (2 doses of 960 mg twice per week) was given regularly as anti-Pneumocystis jirovecii prophylaxis, and fluconazole (1 dose of 200 mg/day p.o.) was given as antimycotic prophylaxis. Supportive therapy with granulocyte colony-stimulating factor and transfusion of erythrocytes and thrombocytes were started, but cellulitis progressed. A computed tomography (CT) scan of the skull and midface showed frontal hypodensity, suggestive of intracerebral abscess formation; signs of pansinusitis; and periorbital edema with orbital inflammation (Fig. 1A). Sinus surgery was performed. Samples of all affected bones were sent for microbiological and pathological examination. Anti-infective therapy was changed to levofloxacin i.v. (1 dose of 500 mg/day) and liposomal amphotericin B i.v. (1 dose of 200 mg/day). Histological examination of the ethmoidal cells revealed a chronic inflammatory infiltrate containing lymphocytes, plasma cells, and a few dispersed granulocytes. Hyphae with almost orthogonal branches, which invaded the mucosal stroma, were seen (Fig. 1B). Invasion into the bones or vascular structures could not be verified. No signs of SplendoreHoeppli phenomenon were found.Direct fluorescence microscopy using calcofluor white (fluorescent fungal cell wall stain; Bay...

show abstract

“…Fungi of the order Entomophthorales are uncommon pathogens, with infection typically restricted to tropical areas and produce chronic cutaneous and subcutaneous infections result from direct inoculation of fungal spores in the skin. In general these infections occur in immunocompetent hosts and progress locally via direct extension into adjacent tissues but ocassionaly are angioinvesive or become disseminated [4,6]. The reverse (dissemination from internal organs to the skin) is very rare [3,7] Roden et al noted such reverse dissemination in only 6 cases (3%).…”

Section: Introductionmentioning

confidence: 99%

Mediastinal Zygomycosis (Mucormycosis): an Unusual Manifestation of Invasive Zygomycosis (Mucormycosis), Presenting as a Mediastinal Mass in an Immunocompetent Adult Male

Ghatavat¹

2014

J Pulm Respir Med

View full text Add to dashboard Cite

The common causes of mediastinal mass are neoplasms including Hodgkin's disease, neuroblastoma and nonHodgkin's lymphoma. About one third of the cases are benign such as teratomas, neurofibromas and lipomas. Histological findings are essential to distinguish between benign and malignant conditions. Zygomycosis is a rare fungal infection usually presenting as a subcutaneous infection. Visceral involvement is reported usually with pulmonary and gastrointestinal tract involvement. Here the authors report a case of zygomycosis in an immunocompetent adult male who presented with mediastinal mass.

show abstract

Rhinofacial Conidiobolus coronatus Infection Presenting with Nasal Enlargement

Cited by 38 publications

References 35 publications

Human Fungal Pathogens of Mucorales and Entomophthorales

Human Fungal Pathogens of Mucorales and Entomophthorales

Rhino-Orbitocerebral Zygomycosis Caused by Conidiobolus incongruus in an Immunocompromised Patient in Germany

Mediastinal Zygomycosis (Mucormycosis): an Unusual Manifestation of Invasive Zygomycosis (Mucormycosis), Presenting as a Mediastinal Mass in an Immunocompetent Adult Male

Contact Info

Product

Resources

About