Rhinologic Symptoms and Quality-of-Life in Patients with Churg-Strauss Syndrome Vasculitis

Srouji, Ibrahim Albert; Lund, Valerie J.; Andrews, Peter; Edwards, Chris

doi:10.2500/ajr.2008.22.3204

Cited by 48 publications

(37 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1441 Systemic manifestations of both sarcoidosis and ChurgStrauss syndrome are managed with chemotherapeutic agents, oral corticosteroids ± immune modulators, but like GPA, the literature supports use of medical management while reserving surgical intervention for persistent rhinologic symptoms in select patients. [1442][1443][1444][1445][1446] Given the epithelial abnormalities present in CGD patients, patients should be counseled regarding suboptimal and/or delayed healing that can follow intranasal procedures.…”

Section: Special Considerations In Rhinosinusitis Xiia Rs Specmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

559

888

View full text Add to dashboard Cite

Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

show abstract

Section: Special Considerations In Rhinosinusitis Xiia Rs Specmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

559

888

View full text Add to dashboard Cite

show abstract

“…On the other hand, crust formation in the nasal cavity was rather uncommon in patients with chronic rhinosinusitis, but it is common in those with GPA. Previous studies have also reported nasal crusting in patients with EGPA, with the incidence of nasal crusting ranging from 14.2 to 75% [Bacciu et al, 2006;Srouji et al, 2008]. This symptom might reflect vasculitis in the mucosa of the nasal cavity and could be used to distinguish EGPA from chronic rhinosinusitis.…”

Section: Discussionmentioning

confidence: 98%

“…Rhinorrhea, nasal obstructions, crust formation and hyposmia were the major symptoms of EGPA [Srouji et al, 2008]. None of these symptoms, except for crusting, are specific to EGPA, and they are often found in patients with chronic rhinosinusitis.…”

Section: Discussionmentioning

confidence: 99%

“…It has also been reported that about three quarters of EGPA patients demonstrate ENT involvement [Bacciu et al, 2006]. However, due to its rarity, there have only been a small number of reports on the otolarynogological manifestations of EGPA [Bacciu et al, 2006[Bacciu et al, , 2008Ishiyama and Canalis, 2001;Srouji et al, 2008]. As EGPA commonly affects the ears and nasal region, otolaryngologists should be aware of this disease and make a diagnosis of EGPA in its early stage.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Otologic and Rhinologic Manifestations of Eosinophilic Granulomatosis with Polyangiitis

et al. 2016

View full text Add to dashboard Cite

Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic autoimmune disease that manifests as asthma, recurrent sinusitis and peripheral eosinophilia. In this study, we investigated the clinical features of the ear and nasal manifestations of EGPA in comparison with those of granulomatosis with polyangiitis (GPA). Materials and Methods: Twenty-one patients diagnosed with EGPA were studied. The frequency of otologic manifestations, the degree of hearing loss and the frequency of nasal symptoms were assessed. The onset of ear symptoms, sinusitis and asthma in patients with EGPA were also examined. Results: Eleven patients (52.4%) with EGPA demonstrated otologic symptoms. The EGPA patients commonly presented mild-to-moderate mixed or sensorineural hearing loss. The pattern of hearing loss was mainly flat, and all but 1 patient achieved complete remission from their hearing impairments. Eighteen patients (85.7%) with EGPA demonstrated nasal symptoms. Patients with EGPA showed a significantly higher incidence of nasal polyps than did those with GPA. The median Lund and Mackey scoring system score was 13.7 for patients with EGPA, and ethmoid sinus shadows were more severe than those of the maxillary sinus. Most ear symptoms associated with EGPA were observed after definitive diagnosis, although sinusitis and asthma tended to manifest themselves before diagnosis. There were significant differences between the onset of ear symptoms and those of asthma and sinusitis. Conclusion: As over 80% of patients with EGPA had nasal symptoms and over half had ear symptoms, otolaryngologists should be aware of this disease. Recognition of the characteristic ear and nasal symptoms are thought to be particularly important to obtain an early diagnosis of EGPA.

show abstract

“…Overall, 80% of CSS patients have active sinonasal symptoms at the time of presentation and worsening of their nasal symptoms may be the main event leading to their diagnosis (Srouji I et al 2008) . Nearly half CSS patients had undergone nasal surgery.…”

Section: Upper Airwaymentioning

confidence: 99%