Rhinorrhea due to Infusion of Dexmedetomidine during Rhinoplasty: A Case Report and Current Literature Review

Yanaral, Tümay Uludağ; Karaaslan, Pelin; Güngör, Hande; Atalay, Yunus Oktay; Tobias, Joseph D.

doi:10.4274/haseki.galenos.2022.8389

Cited by 2 publications

(1 citation statement)

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“…Issues such as a restricted number of patients, selection bias, modified anesthetic protocols, inattentive hemodynamic recording, and the absence of a placebo require thorough assessment and standardization in future controlled studies. From a specific perspective, dexmedetomidine is associated with common adverse events such as rhinorrhea, severe hypotension, hypertension, and notably, bradycardia [39,40]. Motlagh and colleagues suggested using lower loading doses of the alpha agonist to reduce alpha stimulation of vascular smooth muscles.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine versus remifentanil in nasal surgery: a systematic review and meta-analysis

Janipour,

Bastaninejad,

mohebbi

et al. 2024

BMC Anesthesiol

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Background Nasal surgeries, addressing anatomical variations for form and function, require careful anesthesia administration, including dexmedetomidine and remifentanil. This meta-analysis evaluates their safety and efficacy variations in nasal surgeries, emphasizing patient comfort and optimal outcomes. Methods Four electronic databases (PubMed, Scopus, Web of Science, and CINAHL Complete) were searched for records in English. Studies that measure the effect of dexmedetomidine versus remifentanil on patients underwent nasal surgery were included. The Cochrane Collaboration’s tool was used to assess the quality of the included studies. A random-effect model was preferred and statistical analysis was performed by Stata software version 17. Results Out of an initial pool of 63 articles, five studies were selected for this analysis. All of these chosen studies were Randomized Controlled Trials (RCTs). The meta-analysis involved a total of 302 participants, with 152 in the remifentanil group and 150 in the dexmedetomidine group. The analysis aimed to compare the effects of Dexmedetomidine and Remifentanil on heart rate (HR) and mean arterial pressure (MAP) during surgery. Both groups exhibited similar MAP and HR, with the exception of a slightly lower HR in the remifentanil group at the 15th minute of surgery (Standardized Mean Difference: -0.24 [-0.83, 0.34]). Furthermore, when evaluating the impact of these medications on post-surgery outcomes, including pain levels, the use of pain relief medications, patient-surgeon satisfaction, agitation scores, and recovery time, no significant differences were observed between the two medications in any of these aspects. Conclusion In summary, the study compared Dexmedetomidine and Remifentanil in nasal surgeries anesthesia. No significant differences were found in heart rate, blood pressure, satisfaction, pain, agitation, or recovery time. The study had limitations, and future research should establish standardized protocols and consider various surgical factors.

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Section: Discussionmentioning

confidence: 99%