Rhinorrhea: Symptom of Many Diseases!

Karpishchenko, S.A.; Колесникова, О. М.

doi:10.21518/2079-701x-2017-20-68-71

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Кроме того, вазомоторный ринит может развиваться в результате грубого нарушения анатомии структур носа, в частности перегородки носа, гипертрофии носовых раковин. Еще одна из причин жалоб на выделения из полости носаэндокринные заболевания, например гипотиреоз, поэтому лица с длительной ринореей должны быть обследованы на предмет заболеваний щитовидной железы [5].…”

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“…Профессиональный вазомоторный ринит, как правило, характеризуется прерывистыми или стойкими симптомами, такими как заложенность носа, выделения из носа слизистого или водянистого характера, приступообразное чихание, зуд в носу, и является вторичным по отношению к условиям рабочей среды. Несмотря на включение профессионального ринита в группу вазомоторных ринитов, его происхождение может носить как аллергический, так и неаллергический характер [5].…”

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Difficult nasal breathing in the ENT-practice: how to help?

Ryazantsev¹,

Pavlova²

2020

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The article discusses the most common causes of diseases that cause difficulty in nasal breathing. According to the analysis of medical documentation, diseases accompanied by nasal obstruction and rhinorrhea are the most common human diseases. The priority role in the development of the clinical symptoms of rhinitis is played by the release of inflammatory mediators – histamine and bradykinin. Histamine in rhinitis mediates a cascade of pathological reactions, as a result of which local vasodilation develops, accompanied by swelling of the mucous membranes; nasal congestion; increased permeability of the vascular wall; exudation of blood plasma; irritation of nerve endings; triggering reflex mechanisms by stimulating trigeminal histamine receptors. Peculiarities of the course of intermittent and persistent forms of allergic rhinitis, the pathogenesis of allergic inflammation are considered. To reliably eliminate abundant rhinorrhea, combined with nasal congestion, the authors recommend the use of a combined nasal spray, which contains phenylephrine and cetirizine (Phenylephrine + Cetirizine). Based on the analysis of literature data, the effectiveness and safety of the use of the topical form of cetirizine are substantiated. Aspects of the clinical use of the combination of phenylephrine and cetirizine in inflammatory and allergic diseases of the nasal cavity and paranasal sinuses, in the pathogenesis of which the key role is played by swelling of the mucous membrane of the nasal cavity, are examined. It is proved that the new combined nasal spray of domestic production is an effective and safe method for treating patients with manifestations of various forms of rhinitis and nasal obstruction.

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Difficult nasal breathing in the ENT-practice: how to help?

Ryazantsev¹,

Pavlova²

2020

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Nasal decongestants in the treatment of nasal obstruction

Nikitin

Baranskaya

2021

Medicinskij sovet

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Nasal congestion is one of the most common symptoms of common colds and rhinitis, due to an inflammatory reaction, vasodilation, increased nasal blood flow and vascular permeability. Nasal obstruction is often a multifactorial problem, in addition to infectious causes, it can be caused by a combination of anatomical aberrations, swelling of the nasal mucosa and enlargement of the turbinates. Anatomical and structural problems, such as nasal septum deviation and nasal valve collapse, are usually treated surgically. Drug therapy of nasal obstruction is aimed at reducing edema and inflammation of the nasal mucosa. Pharmacotherapy of nasal obstruction is aimed at reducing inflammation and/or swelling of the mucous membrane. Decongestants are widely prescribed to relieve symptoms. The drugs used have different mechanisms of action and include systemic and topical drugs. This article discusses decongestants as a treatment for nasal obstruction. When applied topically, the drugs of this group act directly on the α2 and α1-adrenergic receptors of the nasal cavity, causing vasoconstriction, a decrease in the volume of the nasal conch, an increase in nasal patency, and relieving the symptoms of obstruction. The existing risk of developing side effects, both systemic and local, is reduced with atopic exposure and proper dosing of the drug used. Preferably, the use of drugs with low bioavailability. The suppression of the ciliated epithelium can be caused not only by the pathological process, but also by the composition of drugs. The value is given to the acidity of the buffer system. The optimal pH value of intranasal agents is about 6 (neutral range). The combination with anticholinesterase substances reduces the production of pathological discharge. The use of multi-component medicines allows you to restore nasal breathing and suppress excessive nasal secretion. One of the effective and safe drugs of topical action is Xylometazoline, as a monocomponent agent or in combination with ipratropium bromide.

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Rhinorrhea: Symptom of Many Diseases!

Cited by 2 publications

References 8 publications

Difficult nasal breathing in the ENT-practice: how to help?

Difficult nasal breathing in the ENT-practice: how to help?

Nasal decongestants in the treatment of nasal obstruction

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