Rhinosinusitis in cystic fibrosis: Not a simple story

Babiński, Dariusz; Trawinska-Bartnicka, M.

doi:10.1016/j.ijporl.2008.01.010

Cited by 75 publications

(51 citation statements)

References 17 publications

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“…Any child with NPs should be evaluated for the presence of CF with a sweat test and, potentially, DNA testing. 1421 Children who present with NPs as a component of PCRS represent a distinct subgroup and should be dealt with accordingly. 1422 PCD is a rare cause of PCRS.…”

Section: Xib2 Pediatric Crs: Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

559

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Xib2 Pediatric Crs: Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

559

888

View full text Add to dashboard Cite

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“…Acute infectious rhinosinusitis, chronic allergic rhinosinusitis and non-allergic rhinosinusitis with eosinophilia were also diagnosed. In patients with a typical form, more frequent occurrence of NP was noted than in patients with an atypical form, where allergic rhinosinusitis and non-allergic rhinosinusitis with eosinophilia were found more frequently [9].…”

Section: Introductionmentioning

confidence: 87%

“…Chronic inXammation of sinuses and nasal mucosa is found in 74-100% of patients suVering from CF, whereas NP is found in 6-44% of patients [9].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of rhinosinusitis among atypical cystic fibrosis patients

Marshak

Rivlin

Bentur

et al. 2010

Eur Arch Otorhinolaryngol

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The objective of this paper is to study the correlation between sinonasal involvement and type of cystic fibrosis (CF) in Israeli's CF patients. The comparative study includes 70 CF patients: 40 typical and 30 atypical CF patients. History and physical examination data were recorded, including endoscopic nasal examination as well as sinus computer tomography scan. The data collected from the two groups were statistically analyzed. Twenty-seven percent of atypical CF patients compared with 2.5% of typical CF patients had CF presenting symptoms of chronic rhinosinusitis (CRS) or obstructive nasal polyps (p < 0.001). Although severe CRS was found slightly more often in patient with atypical CF (43 vs. 32.5%), this difference did not reach statistical significance. Nine patients with severe CRS underwent endoscopic sinus surgery. Among these patients, six (66.6%) had atypical CF and only three (33.3%) had typical CF (p = 0.09). In conclusion, severe CRS is a common diagnosis among patients with typical and atypical CF disease. In the current study, no significant difference in the frequency of CRS was found between the two groups. High awareness toward the diagnosis of atypical CF, careful medical history focusing on sinonasal involvement and physical examination, including nasal endoscopy, for all CF patients (typical and atypical CF) may contribute to an early detection and treatment of significant sinonasal involvement, and may improve the quality of life of the patients.

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“…В другом исследовании приняли участие 126 па-циентов с МВ: 90 с типичной клинической карти-ной и 36 с атипичным фенотипом [21]. Для опреде-ления генотипа CFTR было проведено генетическое тестирование.…”

Section: генетикаunclassified