Rhinovirus Infection in Acute Exacerbations of Chronic Bronchitis: A Controlled Prospective Study

Stenhouse, A. C.

doi:10.1136/bmj.3.5563.461

Cited by 57 publications

(21 citation statements)

References 7 publications

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“…There is evidence that respiratory virus infections are associated with more severe and frequent AECB and may contribute to chronic infection in COPD (128). Rhinovirus infection had been shown to be involved in precipitating AECB (133) and a recent study suggests that rhinovirus infection leads to an elevation of lower airway IL-6 levels (134). This worsening of lower airway inflammation may theoretically enhance bacterial proliferation, leading to secondary bacterial involvement in these episodes of AECB as well.…”

Section: Lower Airway Bacterial Colonization During the Stable Statementioning

confidence: 99%

Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

Balter

Forge

Low

et al. 2003

Canadian Respiratory Journal

116

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Acute exacerbations of chronic bronchitis (AECB) account for over 1.5 million physician visits annually in Canada and are a cause of significant morbidity and mortality. This document represents a joint effort between respirologists, microbiologists, infectious disease specialists and family physicians to update the Canadian AECB guidelines published in 1994. Treatment recommendations are graded on the strength of evidence in the published literature where possible. The role for oral corticosteroid therapy in preventing treatment failures, speeding up recovery and delaying the time to next exacerbation is discussed. Risk factors for treatment failure were used to stratify patients into risk groups to help guide antibiotic treatment recommendations. The importance of emerging antimicrobial resistance to current antibiotics is reviewed and strategies to prevent future AECB episodes are suggested.

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Section: Lower Airway Bacterial Colonization During the Stable Statementioning

confidence: 99%

Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

Balter

Forge

Low

et al. 2003

Canadian Respiratory Journal

116

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“…Their importance in the aetiology of the afebrile coryzal syndrome,1 2 3 4 otitis media,5 sinus infection,6 lower respiratory illness including pneumonia,7 8 9 10 11 and exacerbations of chronic bronchitis12 13 14 and asthma15 has been recognised for many years. In the Tecumseh study of respiratory infections in families Monto et al noted an increase in the frequency of lower respiratory illness, restriction in activity, and medical consultations in people over 40 with rhinoviruses compared with younger adults 16.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for lower respiratory complications of rhinovirus infections in elderly people living in the community: prospective cohort study

Nicholson

Kent

Hammersley

et al. 1996

BMJ

144

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Objective-To assess the role of rhinoviruses in elderly people living in the community.Design-Prospective community based surveillance of elderly people, without intervention. Subjects were telephoned weekly to identify symptomatic upper respiratory tract infections. Symptoms and impact of illnesses were monitored, and specimens were collected for diagnostic serology and human rhinovirus polymerase chain reaction.Setting-Leicestershire, England. There were almost six times as many symptomatic rhinovirus infections as influenza A and B infections.Conclusions-Rhinoviruses are an important cause of debility and lower respiratory illness among elderly people in the community. Chronic ill health and smoking increase the likelihood of lower respiratory complications from such infections. The overall burden of rhinovirus infections in elderly people may approach that of influenza.

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“…This tendency was particularly striking in the case of Rhinoviruses. For a long time Rhinoviruses have been regarded as a cause of purely upper respiratory infection, but they are coming increasingly to be suspected as causes of acute exacerbations of chronic bronchitis in adults [1,2]. We found that in the group of chesty children isolation of Rhinoviruses was almost invariably associated with an episode of acute LRD.…”

mentioning

confidence: 67%

A Study of Recurrent Bronchitis in Childhood

Gregg¹

1970

Respiration

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Rhinovirus Infection in Acute Exacerbations of Chronic Bronchitis: A Controlled Prospective Study

Cited by 57 publications

References 7 publications

Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

Canadian Guidelines for the Management of Acute Exacerbations of Chronic Bronchitis

Risk factors for lower respiratory complications of rhinovirus infections in elderly people living in the community: prospective cohort study

A Study of Recurrent Bronchitis in Childhood

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