Rhinovirus Infection in Hospitalized Children in Hong Kong

Cheuk, Dkl; Tang, Ivan; Chan, Kwok Hung; Woo, Patrick C. Y.; Peiris, Malik; Chiu, Susan S.

doi:10.1097/inf.0b013e3181586b63

Cited by 70 publications

(65 citation statements)

References 23 publications

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“…In contrast to previous reports (Calvo et al 2007, 2008, Cheuk et al 2007, Bonzel et al 2008, we observed that HRV-PIV co-infection (median of 1.5 m.o.) was more …”

Section: Discussioncontrasting

confidence: 56%

“…HRV is frequently detected in children diagnosed with bronchiolitis and pneumonia (Manoha et al 2007, Miller et al 2007, Louie et al 2009). Additionally, HRV can cause severe complications in patients that are immunocompromised (Malcolm et al 2001) or have underlying chronic disorders (Kim & Hodinka 1998, Glezen et al 2000, Cheuk et al 2007, Dreschers et al 2007.…”

mentioning

confidence: 99%

“…Previously, diagnosis of HRV was difficult because culture of the virus was limited (Cheuk et al 2007, Paranhos-Baccalà et al 2008). Due to advances in nucleic acid amplification, we can now detect HRV and determine when HRV is the causative agent of lower respiratory tract illness (LRTI) (Choi et al 2006, Miller et al 2007, Gerna et al 2009, Louie et al 2009).…”

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confidence: 99%

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Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Paula

Carneiro

Yokosawa

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…In contrast to previous reports (Calvo et al 2007, 2008, Cheuk et al 2007, Bonzel et al 2008, we observed that HRV-PIV co-infection (median of 1.5 m.o.) was more …”

Section: Discussioncontrasting

confidence: 56%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Paula

Carneiro

Yokosawa

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…Actualmente, se asocian los RVH no solo con IRA del tracto superior, sino también con IRA baja. 12 Nuestros datos confirman la importancia y alta frecuencia de la infección por RVH durante los primeros años de la vida y su asociación con cuadros de IRAB. Hemos observado una alta frecuencia de RVH, similar a lo previamente reportado en otros países.…”

Section: Discussionunclassified

Infección respiratoria aguda viral en niños menores de 5 años. Estudio epidemiológico en dos centros de Buenos Aires, Argentina

Vidaurreta

Marcone

Ellis³

et al. 2011

Arch Argent Pediat

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Arch Argent Pediatr 2011;109(4):296-304 / 296 RESUMEN Introducción. Las infecciones respiratorias agudas (IRA) son la mayor causa de hospitalización en edades extremas de la vida. Objetivos. Identificar los agentes etiológicos de IRA viral en niños < 5 años hospitalizados y ambulatorios; describir estacionalidad y caracterís-ticas clínico-epidemiológicas de la enfermedad. Población y métodos. Estudio descriptivo, transversal y multicéntrico en dos centros privados de Buenos Aires, en niños con IRA alta y baja. Se registraron antecedentes, cuadros clínicos y estudios virológicos. Resultados. Se estudiaron 347 pacientes: 235 hospitalizados; 112 ambulatorios. Los hospitalizados fueron menores que los ambulatorios (8 vs. 19 meses, p <0,001), presentaron más frecuentemente bronquiolitis (74% hospitalizados vs. 24% ambulatorios) y neumonía (14% hospitalizados vs. 5% ambulatorios). Solo la edad se asoció significativamente a hospitalización (p= 0,01). Se identificó etiología viral en 81% de los hospitalizados y 57% de los ambulatorios. El virus más frecuente fue rinovirus seguido por virus respiratorio sincicial. Se observó circulación viral durante todo el año, especialmente en otoño e invierno. En pacientes hospitalizados, la mediana de hospitalización fue 3,5 días. Requirieron cuidados intensivos 25 (11%) pacientes, y 7 (3%) recibieron asistencia ventilatoria mecánica. No hubo letalidad. Conclusiones. Las técnicas de diagnóstico virológico permitieron identificar agentes etiológicos en la mayoría de los pacientes hospitalizados y en más de la mitad de los ambulatorios con IRA. La incorporación de RT-PCR para rinovirus, permitió la identificación de este agente etioló-gico. La circulación viral se observó a lo largo de todo el año. La bronquiolitis fue causa de internación en 174/201 (86,5%) niños con IRA y la neumonía en 33/39 (84,6%) niños. Palabras clave: virus respiratorios, infección respiratoria aguda, bronquiolitis, RT-PCR, rinovirus. SUMMARY Introduction. Acute respiratory infections (ARI)are a major cause of hospitalization particularly at the extreme ages of life. Objectives. To determine the viral diagnosis in children < 5 years old with ARI, seasonality, clinical and epidemiological characteristics. Population and methods. A cross-sectional, descriptive and multicenter study was performed. Respiratory samples from patients with ARI hospitalized or outpatients with < 5 days of respiratory symptoms from June 2008 to May 2009 were studied for respiratory viruses. Clinical and demographic data were recorded. Results. A total of 347 patients were enrolled: 234 hospitalized and 112 outpatients. Hospitalized patients were younger compared with outpatients (8 vs. 19 months, p <0.001) and presented more frequently bronchiolitis (74% hospitalized vs. 24% outpatients) and pneumonia (14% hospitalized vs. 5% outpatients). Age was statistically associated with hospitalization (p= 0.01). Viral diagnosis was achieved in 81% hospitalized and 57% of outpatients. Rhinovirus was the most frequent followed by respiratory sync...

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“…Respiratory viral infections are the factor most strongly associated with precipitation of acute asthma exacerbations in various populations [36][37][38]. RVs are the predominant aetiological agents associated with exacerbations; however, other viruses, such as coronavirus, influenza virus, adenovirus, RSV and parainfluenza virus, Mycoplasma pneumoniae and Chlamydophila pneumoniae have been also identified, although to a lesser extent [39].…”

Section: Infection Among Factors Precipitating Asthma Exacerbationsmentioning

confidence: 99%

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers: Figure 1–

Xepapadaki¹,

Papadopoulos²

2010

Eur Respir J

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Respiratory infections have been implicated in the origin and exacerbation of asthma in a variety of ways; however, systemisation of this knowledge in a way helpful for disease management remains suboptimal.Several conceptual issues need to be taken into account: the fact that the effects of an infection may vary according to genetic background, the current immune status of the host, and parallel environmental stimuli, in addition to the particular infectious agent itself. Moreover, childhood is a very special period because of the continuous processes taking place, such as neural, immune and respiratory maturation.Epidemiological studies have convincingly demonstrated that the majority of asthma exacerbations, in both adults and children, follow viral upper respiratory tract infections. Asthma exacerbations are still often unresponsive to current asthma treatment, and new therapeutic approaches are required.This review presents current knowledge on the associations between infection and exacerbation of established asthma with respect to definitions, epidemiology, mechanisms and treatment.

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Rhinovirus Infection in Hospitalized Children in Hong Kong

Abstract: Rhinovirus is frequently associated with asthmatic exacerbations and lower respiratory tract infection, especially in children with chronic diseases and is potentially an important contributor to hospitalization in children in Hong Kong.

Cited by 70 publications

References 23 publications

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Infección respiratoria aguda viral en niños menores de 5 años. Estudio epidemiológico en dos centros de Buenos Aires, Argentina

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers: Figure 1–

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