Rhinovirus infections in chronic bronchitis: isolation of eight possibly new rhinovirus serotypes

Stott, E. J.; Grist, N. R.; Eadie, M. B.

doi:10.1099/00222615-1-1-109

Cited by 37 publications

(28 citation statements)

References 3 publications

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“…Although other studies have shown that respiratory virus infections may lead to exacerbations in patients with chronic chest disease [1][2][3][4][5][6][7][8][9][10] recently been described and evaluated in our laboratory [26]. RT The results of this study illustrate the morbidity and undoubted economic importance of respiratory virus infections.…”

Section: Discussionmentioning

confidence: 78%

“…Respiratory virus infections are frequently associated with exacerbations of chronic bronchitis [1][2][3][4] or asthma [5][6][7][8][9][10], and patients with chronic chest disease appear to have an increased susceptibility to respiratory tract infections when compared to their spouses [ 11 ] or siblings [ 1 2]. Annual influenza vaccine is recommended for high-risk patients, including those with respiratory disease [ 13]; however, vaccines are not currently available against other respiratory viruses.…”

Section: Introductionmentioning

confidence: 99%

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Impact of respiratory virus infection in patients with chronic chest disease

et al. 1993

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SUMMARYThis study investigated the morbidity associated with respiratory virus infections in patients with well-documented chest disease, and the risk of transmission between close contacts. Patients informed the study team if they were exposed to a family member or colleague with a cold. Patients and symptomatic index cases recorded respiratory symptoms during the study period. Acute nasopharyngeal swabs and paired sera were obtained for viral diagnosis.Twenty-five (43 %) of 58 recorded exposures resulted in a symptomatic illness and 16 (28%) patients developed lower respiratory tract symptoms. Sixteen (64%) of the 25 symptomatic patients contacted their general practitioner, 14 (56 %) received antibiotics and 4 (16 %) were hospitalized. Mean duration of illness was 106 days in symptomatic patients and 5-7 days in their corresponding index cases (P < 0005). Mean symptom scores were 100X6 in symptomatic patients and 62-2 in index cases (P < 0 01). Respiratory viruses were identified in 19 (33%) episodes. Rhinovirus, coronavirus and respiratory syncytial virus infections were all associated with lower respiratory tract exacerbations.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Impact of respiratory virus infection in patients with chronic chest disease

et al. 1993

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“…In a study of 44 chronic bronchitics over 2 yrs, STOTT et al [19] found rhinovirus in 13 (14.9%) of 87 exacerbations of chronic bronchitis using viral culture methods. In a more detailed study of 25 chronic bronchitics with 116 exacerbations over 4 yrs and using similar methods, GUMP et al [9] found that only 3.4% of exacerbations could be attributed to rhinovirus.…”

Section: Discussionmentioning

confidence: 99%

“…Viruses are important triggers of COPD exacerbation [9,19] but rhinovirus has not hitherto been considered to be of much significance during exacerbations of COPD. In a study of 44 chronic bronchitics over 2 yrs, STOTT et al [19] found rhinovirus in 13 (14.9%) of 87 exacerbations of chronic bronchitis using viral culture methods.…”

Section: Discussionmentioning

confidence: 99%

Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease

Seemungal

Harper-Owen²,

Bhowmik³

et al. 2000

Eur Respir J

310

208

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Common colds are associated with exacerbations of chronic obstructive pulmonary disease (COPD). However, the role of the common cold virus (human rhinovirus) in the production of symptoms and lower airway inflammation at COPD exacerbation is unknown.Thirty three patients with moderate-to-severe COPD were seen at baseline, when the number of chest infections in the previous year was noted, and acutely at COPD exacerbation. Within 48 h after the onset of the exacerbation and at baseline, nasal aspirates and induced sputum were taken for rhinovirus reverse transcriptase polymerase chain reaction (RT-PCR) analysis and determination of cytokine levels. Symptoms, recorded on diary cards, were noted and forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) measured.At exacerbation, mean FEV1 and FVC fell significantly from baseline (p<0.001). Ten of 43 exacerbations were associated with rhinovirus infection, detected in induced sputum. In four of these, nasophageal samples contained no detectable rhinovirus. All baseline samples were negative for rhinovirus. The simultaneous presence of increased nasal discharge/nasal congestion (in 26 of the 43 exacerbations) and increased sputum (29 exacerbations) was strongly associated with the presence of rhinovirus (odds ratio 6.15; p=0.036). Total symptom scores were greater for rhinovirus as compared to nonrhinovirus exacerbations (p=0.039). Median baseline sputum interleukin-6 levels rose from 90.2 to 140.3 pg . mL -1 at exacerbation (p=0.005); the change was greater in the presence of rhinovirus infection (p=0.008).Rhinovirus infection can be detected at chronic obstructive pulmonary disease exacerbation. This is associated with elevation of lower airway interleukin-6 levels, which may mediate lower airway symptom expression during chronic obstructive pulmonary disease exacerbations. Eur Respir J 2000; 16: 677±683.

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“…Serum-neutralizing antibody titres remain elevated for many years after infection (2,9,10). However, local specific antibody appears to be lost with time: that produced after intranasal rhinovirus vaccination was lost after 2 years (11).…”

Section: Introductionmentioning

confidence: 99%

The time course of the humoral immune response to rhinovirus infection

et al. 1989

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SUMMARYThe specific humoral immune response of 17 volunteers to infection with human rhinovirus type 2 (HRV-2) has been measured both by neutralization and by ELISA. Six volunteers who had HRV-2-specific antibodies in either serum or nasal secretions before HRV-2 inoculation were resistant to infection and illness. Of the remaining 11 volunteers who had little pre-existing HRV-2-specific antibody, one was immune but 10 became infected and displayed increases in HRV-2-specific antibodies. These antibodies first increased 1-2 weeks after infection and reached a maximum at 5 weeks. All six resistant volunteers who had high pre-existing antibody and eight of the volunteers who became infected maintained their HRV-2-specific antibody for at least 1 year. At this time they were protected against reinfection. Two volunteers showed decreases in HRV-2-specific antibodies from either serum or nasal secretions. They became infected but not ill after HRV-2 inoculation 1 year later.

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Rhinovirus infections in chronic bronchitis: isolation of eight possibly new rhinovirus serotypes

Cited by 37 publications

References 3 publications

Impact of respiratory virus infection in patients with chronic chest disease

Impact of respiratory virus infection in patients with chronic chest disease

Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease

The time course of the humoral immune response to rhinovirus infection

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