Rho family GTPase signaling through type II p21-activated kinases

Chetty, Ashwin; Ha, Byung Hak; Boggon, Titus J.

doi:10.1007/s00018-022-04618-2

Cited by 8 publications

(1 citation statement)

References 188 publications

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“…These proteins downstream of CaMK include Rho guanine exchange factors and Rho guanosine triphosphatases, which may activate many proteins, including Rho kinase (ROCK) and p21-activated kinase (PAK). Both PAK and ROCK activate LIM (Lin-11/Isl-1/Mec-3) domain–containing protein kinase 1 (LIMK1) ( 11 ), resulting in the inactivation of actin-depolymerizing factor (ADF)/cofilin, leading to actin polymerization and subsequent enlargement and stabilization of dendritic spines (Fig. 1A) ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Engineering memory with an extrinsically disordered kinase

Ripoli,

Dagliyan,

Renna

et al. 2023

Sci. Adv.

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Synaptic plasticity plays a crucial role in memory formation by regulating the communication between neurons. Although actin polymerization has been linked to synaptic plasticity and dendritic spine stability, the causal link between actin polymerization and memory encoding has not been identified yet. It is not clear whether actin polymerization and structural changes in dendritic spines are a driver or a consequence of learning and memory. Using an extrinsically disordered form of the protein kinase LIMK1, which rapidly and precisely acts on ADF/cofilin, a direct modifier of actin, we induced long-term enlargement of dendritic spines and enhancement of synaptic transmission in the hippocampus on command. The activation of extrinsically disordered LIMK1 in vivo improved memory encoding and slowed cognitive decline in aged mice exhibiting reduced cofilin phosphorylation. The engineered memory by an extrinsically disordered LIMK1 supports a direct causal link between actin-mediated synaptic transmission and memory.

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Section: Introductionmentioning

confidence: 99%

Engineering memory with an extrinsically disordered kinase

Ripoli,

Dagliyan,

Renna

et al. 2023

Sci. Adv.

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Plexin D1 negatively regulates macrophage-derived foam cell migration via the focal adhesion kinase/Paxillin pathway

Li,

Niu,

Chen

et al. 2024

Biochemical and Biophysical Research Communications

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Niobium Nanoparticles Activates Endothelial Tip Cells and Promotes Angiogenesis by FOXA1-PAK4-YAP Signaling Pathway

Mo,

Xie,

Chen

et al. 2024

ACS Appl. Nano Mater.

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Inadequate vascularization is a major challenge in tissue engineering and can lead to the failure of tissue defect repair. Currently, the use of nanomaterials has emerged as a critical strategy for tissue engineering. Nanoparticles can be utilized as additives in composite materials to enhance the development of bone tissue engineering. Niobium (Nb), a transition metal element with notable biocompatibility, has potential in angiogenesis. However, the effect of Nb nanoparticles (a form of niobium in the nanoparticle state) on endothelial cell behavior remains unclear. This study focused on the effect of Nb nanoparticles on the differentiation of tip cells and its in-depth regulatory mechanism. Our results revealed that Nb nanoparticles promoted angiogenesis at an early stage and increased bone regeneration in calvarial bone defects. In addition, Nb nanoparticles activated tip cell differentiation and thereby promoted cell migration and tube formation. Furthermore, we verified that Nb nanoparticles promoted endothelial tip cell formation by activating YAP. Nb nanoparticles regulates YAP through the newly identified upstream regulatory molecules FOXA1 and PAK4. When FOXA1 or PAK4 was inhibited, YAP expression and tip cell activation were inhibited. Thus, Nb nanoparticles promoted angiogenesis by activating endothelial tip cells, and the FOXA1-PAK4-YAP signaling cascade regulated this process. The insights garnered from this study suggest a strategy for tissue engineering and lay a theoretical foundation for the expanded application of Nb nanoparticles in this field.

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Rho family GTPase signaling through type II p21-activated kinases

Cited by 8 publications

References 188 publications

Engineering memory with an extrinsically disordered kinase

Engineering memory with an extrinsically disordered kinase

Plexin D1 negatively regulates macrophage-derived foam cell migration via the focal adhesion kinase/Paxillin pathway

Niobium Nanoparticles Activates Endothelial Tip Cells and Promotes Angiogenesis by FOXA1-PAK4-YAP Signaling Pathway

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