Rho-kinase Inhibitor: A Potential Alternative to Current Glaucoma Therapy

Abstract

Glaucoma is a group of progressive and irreversible optic neuropathies linked to intraocular pressure-related damage of the optic head. It is the second leading cause of blindness with estimation of 76 million people affected. Among many types of glaucoma, Primary Open-Angle Glaucoma (POAG) is the most common. Management of POAG primarily focus on lowering IOP with a variety of topical, oral, intravenous therapy, and surgery. Prostaglandin Analogue and Beta-blocker have long been the first line therapy for POAG with proven efficacy and safety profile. Rho-kinase Inhibitor is a novel class of drug with IOP lowering property through its ability to increase aqueous humor drainage via trabecular meshwork. Rho-kinase Inhibitor is proven to have mild local adverse effects and rare systemic drug reaction. This might be beneficial for patients with contraindication to Prostaglandin Analogue and/ or Beta-blocker use. Keywords: glaucoma, rho-kinase inhibitor

Inhibidores RHO quinasa en el tratamiento del glaucoma de ángulo abierto.

“…En tanto Putrea et al (23) señalan que los efectos secundarios oculares, que se presentan con mayor frecuencia son hiperemia conjuntival, hemorragia conjuntival, conjuntivitis alérgica, ojo seco y blefaritis. Que, en comparación con los medicamentos tradicionales para el glaucoma, son leves y rara vez ocurren, lo cual podría beneficiar a los inhibidores de rho quinasa en comparación con otros medicamentos tópicos para el glaucoma, como el Latanoprost, en el que la periorbitopatía es muy frecuente, fundamentalmente cuando se utiliza de forma unilateral.…”

“…El proceder terapéutico tiene la finalidad de disminuir PIO, lo que constituye la primera línea de tratamiento del glaucoma, y así prevenir una progresión en el deterioro del nervio óptico, teniendo en cuenta que es la única causa de la enfermedad que se puede modificar con tratamiento farmacológico (23). En el tratamiento para la reducción de la producción de humor acuoso se señalan los siguientes (24):…”

Environmental Care Behavior through Waste Bank (Study at Teratai Waste Bank Pondok Pucung Sub-district, Pondok Aren District, South Tangerang City)

“…Next is the city of South Tangerang, which produces 355 thousand tons of waste. Followed by Lebak Regency, which produced 215.88 thousand tons of waste, then Serang City, which produced 213.464 waste, and finally, Cilegon City, which produced 83.16 thousand tons of waste (Putra, Permana, & Panulisan, 2022). This number will undoubtedly continue to grow along with the population rate; the increase in the amount of waste, if not in line with proper management, will cause various environmental impacts such as water and air pollution, soil degradation, and ecosystem damage.…”