Hypoxic Pulmonary Vasoconstriction
DOI: 10.1007/1-4020-7858-7_24
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Rho/Rho-kinase Signaling in Hypoxic Pulmonary Hypertension

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Cited by 22 publications
(34 citation statements)
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“…Thus, the early transient induction of miR-17z92 may reflect the reactivation of this developmental program in the pathogenesis of PAH. Similarly, reactivation of Rho/Rhokinase signaling (50) and Notch3 in PASMC is reported to promote PAH (51). It was a bit puzzling how the reduction in miR-17z92 levels during the later stage of hypoxic exposure fit into the etiopathology of PH, given that miR-17z92 inhibitors can reverse existing PH (19).…”
Section: Discussionmentioning
confidence: 99%
“…Thus, the early transient induction of miR-17z92 may reflect the reactivation of this developmental program in the pathogenesis of PAH. Similarly, reactivation of Rho/Rhokinase signaling (50) and Notch3 in PASMC is reported to promote PAH (51). It was a bit puzzling how the reduction in miR-17z92 levels during the later stage of hypoxic exposure fit into the etiopathology of PH, given that miR-17z92 inhibitors can reverse existing PH (19).…”
Section: Discussionmentioning
confidence: 99%
“…McMurtry et al (34) reported that chronic PHT was attenuated by enteral (via mother's milk) fasudil over the first 8 wk of life in fawn-hooded rats at Denver altitude. It was further suggested that fasudil enhanced alveolar development, although morphometric analyses were not performed (34). Our observations differ in that neither Y-27632 nor fasudil had any impact on hypoxiainduced septal thinning or alveolarization, as assessed by secondary crest counts.…”
Section: Discussionmentioning
confidence: 99%
“…156,157 The contractile state of VSMCs is regulated by phosphorylation (causing contraction) and dephosphorylation (causing relaxation) of the 20-kDa regulatory myosin light chain (MLC). Phosphorylation of MLC is catalyzed by Ca 2ϩ /calmodulin-dependent MLC kinase (MLCK) and dephosphorylation by calcium-independent MLC phosphatase (MLCP), which is targeted to myosin by its regulatory myosin binding subunit (MBS).…”
Section: Chronic Hypoxia-induced Changes In Ionic Balance and Calciummentioning
confidence: 99%