Rhodamine B oxidation promoted by P450-bioinspired Jacobsen catalysts/cellulose systems

Bolzon, Lucas B.; Bindeiro, Anna Karolina dos Santos; Souza, Ana Luiza Marques de Oliveira; Zanatta, Lucas D.; Paula, Regina C.M. de; Cerqueira, Bruna Costa; Santos, Joicy Santamalvina dos

doi:10.1039/d1ra04915a

Cited by 2 publications

(1 citation statement)

References 93 publications

(106 reference statements)

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“…To produce products from licarin A, different catalysis conditions were evaluated applying four solvents (MeOH, DCM, ACN, and EtOAc) and two oxygen donors (PhIO and mCPBA) and under the action of two catalysts ([Fe(TTP)Cl] or Mn(Salen)) in all possible combinations. The Jacobsen catalyst Mn(Salen) has an electronic structure and catalytic activities similar to metalloporphyrins, generally catalyzing epoxidation reactions [17]. The variation in oxidant concentration and reaction time was first evaluated, and the most suitable molar ratio of reagents was 1 : 30 : 30 (catalyst : substrate : oxidant), with the reactions kept under stirring for 24 h.…”

Section: Resultsmentioning

confidence: 99%

Oxidation Products from the Neolignan Licarin A by Biomimetic Reactions and Assessment of in vivo Acute Toxicity

et al. 2023

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Licarin A, a dihydrobenzofuranic neolignan presents in several medicinal plants and seeds of nutmeg, exhibits strong activity against protozoans responsible for Chagas disease and leishmaniasis. From biomimetic reactions by metalloporphyrin and Jacobsen catalysts, seven products were determined: four isomeric products yielded by epoxidation from licarin A, besides a new product yielded by a vicinal diol, a benzylic aldehyde, and an unsaturated aldehyde in the structure of the licarin A. The incubation with rat and human liver microsomes partially reproduced the biomimetic reactions by the production of the same epoxidized product of m/z 343 [M + H]+. In vivo acute toxicity assays of licarin A suggested liver toxicity based on biomarker enzymatic changes. However, microscopic analysis of tissues sections did not show any tissue damage as indicative of toxicity after 14 days of exposure. New metabolic pathways of the licarin A were identified after in vitro biomimetic oxidation reaction and in vitro metabolism by rat or human liver microsomes.

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Section: Resultsmentioning

confidence: 99%

Oxidation Products from the Neolignan Licarin A by Biomimetic Reactions and Assessment of in vivo Acute Toxicity

et al. 2023

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Highly efficient oxidative degradation of organic dyes by using magnetically recyclable nanocatalyst based on manganese-porphyrin

Rayati,

Aghajani,

Nejabat

et al. 2024

Polyhedron

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Rhodamine B oxidation promoted by P450-bioinspired Jacobsen catalysts/cellulose systems

Abstract: P450-bioinspired Jacobsen/Cell(NEt2) catalysts have been applied in RhB dye oxidation, which is used illegally in food industries of some countries.

Cited by 2 publications

References 93 publications

Oxidation Products from the Neolignan Licarin A by Biomimetic Reactions and Assessment of in vivo Acute Toxicity

Oxidation Products from the Neolignan Licarin A by Biomimetic Reactions and Assessment of in vivo Acute Toxicity

Highly efficient oxidative degradation of organic dyes by using magnetically recyclable nanocatalyst based on manganese-porphyrin

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