Rhodamine based sensor for naked-eye detection and live cell imaging of fluoride ions

Abstract

A rhodamine based highly selective colorimetric and fluorescent probe for fluoride has been designed and synthesized. The fluorescent change is attributed to the fluoride triggered spirolactam ring opening which is augmented by density functional theory calculations and 1 H NMR titrations. The sensor has been shown to be feasible for real sample analysis, and imaging of fluoride ions in the HeLa cells. À ) in HEPES buffer (20 mM, pH 7.4) Scheme 1 Synthesis of the probe RDF-1.

Aminobenzohydrazide based colorimetric and ‘turn-on’ fluorescence chemosensor for selective recognition of fluoride

“…In continuation of our ongoing research for the development of fluorescent chemosensor for anions and cations [49][50][51][52][53][54], herein we have synthesized two chemosensors. These sensors comprise of 2-aminobenzohydrazide as receptors, and anthracene/pyrene as fluorophores.…”

A novel piperazine-bis(rhodamine-B)-based chemosensor for highly sensitive and selective naked-eye detection of Cu2+ and its application as an INHIBIT logic device

“…The rhodamine derivatives are non-fluorescent and colorless, whereas when they coordinate with some metal ions, the ring-opening of the corresponding spirolactam gives off a strong fluorescent emission and pink color [36][37][38][39]. Based on this mechanism, some rhodamine-based spirolactam probes have been reported for the recognition of different metal ions [35,[40][41][42].…”

A water-soluble pH fluorescence probe based on quaternary ammonium salt for bioanalytical applications

“…Currently, lots of novel fluorescence probes were reported based on the philosophy that the combination between the proton and the lone pair electrons within nitrogen, which could change the optical properties of fluorescent probes [33][34][35][36][37][38], besides that, pH-induced ring-opening reaction of the rhodamine is broadly used by varying the conjugated system [39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]. Even though lots of rhodamine-based fluorescence probes have been widely applied in both solution and biosensing systems to discriminate the analytes from other biological abundant species so far, poor solubility of these probes in biological environments might result in decreased detection sensitivity, or even lose the response signal, which is a research bottleneck as regards progress in some areas of cell biology or medicine [55][56][57][58].…”