Rhodiola rosea in vitro culture - phytochemical analysis and antioxidant action

Furmanowa, M.; Skopińska-Różewska, Ewa; Rogala, E; Hartwich, Małgorzata

doi:10.5586/asbp.1998.009

Cited by 48 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have investigated the immunotropic activity of alcoholic and aqueous extracts of roots and rhizomes of Rhodiola plants in mice, rats and pigs. During the initial investigation (11), not a large quantity of information was available about the immunotropic activity of Rhodiolas. Further studies showed that the majority of Rhodiola extracts stimulated immunity (12,13).…”

Section: Introductionmentioning

confidence: 99%

Modulatory effects of feeding pregnant and lactating mice Rhodiola kirilowii extracts on the immune system of offspring

Lewicki

Bałan

Skopińska-Różewska

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Plants of genus are medicinal herbs that have a number of therapeutic properties, including anti-inflammatory and immunomodulatory activity. The present study aimed to determine whether the use as an immunostimulant during pregnancy has an adverse effect on the development of the offspring immune system. Following mating, pregnant mice were placed in three groups that were fed during pregnancy and lactation with aqueous extract (RKW; 20 mg/kg), 50% hydro-alcoholic extract (RKW-A; 20 mg/kg) or water (control group), receiving water. Following birth, offspring were given six weeks to develop prior to evaluation of their immune system. Morphometric and morphological examination of the spleen did not reveal any abnormalities or differences between the experimental and control groups. However, both RKW and RKW-A splenic lymphocytes presented a diminished proliferative response to concanavalin A. RKW spleen lymphocytes demonstrated increased metabolic activity following phytohaemagglutinin (PHA) stimulation, which was associated with a higher percentage of cluster of differentiation 4 positive spleen cells and lower interleukin-17a (IL-17a) serum concentration. The RKW-A group exhibited a diminished proliferative response of spleen lymphocytes to PHA and lipopolysaccharide (LPS), and increased serum concentrations of IL-10 and tumor necrosis factor-α (TNF-α). The progeny of mice fed with RKW-A extract demonstrated a significantly lower level of anti-SRBC antibody following immunization compared with progeny of the control (P=0.0305) and RKW (P=0.0331) groups. In conclusion, caution is recommended in the use of RKW and RKW-A extracts as immunostimulants in pregnancy.

show abstract

Section: Introductionmentioning

confidence: 99%

Modulatory effects of feeding pregnant and lactating mice Rhodiola kirilowii extracts on the immune system of offspring

Lewicki

Bałan

Skopińska-Różewska

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…In recent years, our studies have shown that extracts from plants belonging to Rhodiola species can enhance various in vitro and in vivo parameters of cellular immunity in mice, rats and pigs, which has become a goal for research (Furmanowa et al 1998, Siwicki et al 2007, Skopińska-Różewska et al 2008d, 2010, 2011, Wójcik et al 2008, 2009a,b,c, Bany et al 2009, Hartwich 2010, Zdanowski et al 2014, Lewicki et al 2015.…”

Section: Discussionmentioning

confidence: 98%

Feeding Pregnant and Lactating Mice Rhodiola kirilowii Extracts helps to Preserve Thymus Function of their Adult Progeny

Bien¹,

Lewicki²,

Zdanowski³

et al. 2016

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

Plants belonging to Rhodiola kirilowii species, members of Rhodiola genus and Crassulaceae family, grow wildly in Tibet, Mongolia and China mountains and are traditionally used as adaptogens, antidepressants and anti-inflammatory remedies. Nowadays, R. kirilowii is cultivated in some countries, also in Poland. In our previous papers we reported immuno-and angio-modulatory effects of aqueous and hydro-alcoholic extracts of radix and rhizome of this plant in non-pregnant and pregnant mice. The aim of the present study was to evaluate the effect of feeding pregnant and further lactating mice these extracts on selected thymus function parameters in adult progeny. The counts of M-30+ apoptotic cells, in the thymuses obtained from progeny of mice fed during pregnancy and lactation water or 50% water-alcoholic extract of Rhodiola kirilowii, were significantly lower (p<0.05) than apoptotic cells counts observed in the control mice. No significant differences in the counts of IL-7-positive cells in the thymuses obtained from progeny of the control mice and mothers treated with water or hydro-alcohol extracts of Rhodiola kirilowii were observed.

show abstract

“…It grows mainly in dry sandy ground at high altitudes in the arctic areas of Europe and Asia, Traditional folk medicine used R. rosea to increase physical endurance, work productivity, longevity, resistance to high altitude sickness, and to treat fatigue, depression, anemia, impotence, gastrointestinal ailments, infections, and nervous system disorders [27]. R. rosea is rich in phenolic compounds, known to have strong antioxidant properties [28] (Figure 6). …”

Section: Antiagingmentioning

confidence: 99%