Rhodium‐Catalyzed C(sp ³ )H Functionalization

Abstract

Enormous progress has been made in the functionalization of CH bonds in the last two decades as testified by the great number of publications that have appeared in the literature. Herein, a comprehensive overview on the rhodium‐catalyzed functionalization of C(sp 3 )H bonds including activated C(sp 3 )H bonds, including a CH bond adjacent to a nitrogen atom or benzylic CH bond until spring 2021 is presented.

Recent advances in Rh(i)-catalyzed enantioselective C–H functionalization

“…investigated in asymmetric C-H functionalization with diverse mechanisms. [32][33][34][35][36][37][38][39][40][41][42][43][44][45] From the viewpoint of substrate activation modes, Rh-catalyzed C-H functionalization could be classified into two categories: inner-sphere mechanism and outer-sphere mechanism, which differ in the mechanism of the C-H activation step (Scheme 1). 46,47 Generally, Rh(III)-catalyzed asymmetric C-H functionalization adopts the inner-sphere mechanism by taking advantage of a chiral cyclopentadienyl (Cp) ligand, 35,38,39,[48][49][50][51] whereas Rh(II) usually coordinates with a chiral carboxylic acid to achieve the effect of asymmetric C-H functionalization via the outer-sphere mechanism, 14,[52][53][54] both of which have been well reviewed elsewhere.…”