Rhodium(I)‐Catalyzed Hydroacylation

Recent advances in Rh(i)-catalyzed enantioselective C–H functionalization

“…Rh(I)-catalyzed hydroacylations and Friedel-Crafts reactions have been the subject of multiple reviews and are therefore not covered here. 55,56 We believe that this review will gain much attention from researchers with C-H functionalization and asymmetric transition metal catalysis backgrounds, stimulate more future efforts in this area, and facilitate the synthetic application of these novel reactions. We have structured the literature according to substrate activation modes and reaction types.…”

Rhodium(I) Catalyzed Hydroacylation Reactions of Alkenyl Compounds

“…The hydroacylation of a variety of unsaturated hydrocarbons with chelating or non-chelating aldehydes by virtue of the formyl C(sp 2 )À H bond activation is one of the most valuable chemical transformations for the construction of carbonyl compounds. [1][2][3][4][5][6][7][8][9][10] Consequently, considerable research interests have been attracted to olefin and carbonyl hydroacylation in pursuing the highly efficient and completely atomeconomical synthesis (Scheme 1). Conceptually, the hydroacylation reaction proceeds through the addition of the hydrogen and acyl moieties of an aldehyde across an unsaturated double/triple bond or a carbonyl scaffold.…”

Selective cross-coupling of α,β-unsaturated nitriles with aldehydes or alcohols by hydrogen transfer catalysis towards β-ketonitriles and glutaronitriles

“…Metal-catalyzed hydroacylation of alkenes with aldehydes is one of the most straightforward and atom-economical approaches for synthesizing ketones. 7,8 To prevent the easy decarbonylation of the acyl metal hydride intermediate, pre-installation of an additional chelating group on the aldehyde is often required. 9–14 Thus, hydroacylation of alkenes with non-chelating aldehydes is more attractive.…”