Rhodium(I)‐Catalyzed Reductive Carbon–Carbon Bond Formation

Calow, Adam D. J.; Bower, John F.

doi:10.1002/9783527811908.ch7

Cited by 1 publication

(1 citation statement)

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“…7 Since then, enzymes have been isolated, mass-produced, and re-engineered to fit almost any chemical reaction by the application of highly complex protein engineering techniques, like directed evolution [8][9][10] and in silico or de novo enzyme design. 11,12 While chemical catalysis with various metal catalysts is still prevalent in industrial organic synthesis, [13][14][15] it shows its own drawbacks in the form of high market price and limited availability of required precious metals, like rhodium and palladium, 16 along with multiple protection and de-protection steps that make the process economically unfeasible, and may result in the production of large amounts of dangerous or toxic waste. 17,18 Those drawbacks are especially noticeable in the pharmaceutical industry, which is known for its long and rigorous drug design and production times.…”

Section: Introductionmentioning

confidence: 99%

Biocatalysis for the Production of Pharmaceutical Intermediates

2019

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The application of enzymes in chemical synthesis, due to the recent advances, has a strong impact in multiple industries, especially the pharmaceutical industry. Namely, the use of enzymes shows remarkable advantages over classical chemical catalysis and therefore it is considered a ‘green’ solution. By using novel techniques, it is possible to tailor the enzymes to adapt them for a given process. Today, several pharmaceutical companies are successfully producing valuable precursors for the production of active pharmaceutical ingredients using enzymes, some of them being statin precursors. Statins are hypolipidemics, drugs used for the prevention of cardiovascular diseases and lowering cholesterol concentration in blood. Due to challenges in the chemical synthesis of statin intermediates, the production of statin intermediates using enzyme-catalysed reactions shows some notable advantages. Therefore, research and development laboratories, combined with reaction engineering techniques, have shifted their focus towards applying biochemical catalysis for the production of statin intermediates.

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