Rhodium(II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ring

Designing ‘Totem’ C2‐Symmetrical Iron Porphyrin Catalysts for Stereoselective Cyclopropanations

“…The ring strain of cyclopropanes furnishes them with a number of interesting peculiarities which are crucial when using this class of molecules as pharmaceutical and/or biological agents as well as versatile building blocks in organic synthesis . Consequently, the interest of the scientific community in developing new protocols to obtain these compounds is growing and great efforts have been made to fine‐tune the eco‐compatibility of the processes to respect social requests for sustainable synthetic chemistry.…”

Chemically Sustainable and Green One‐Pot Multicomponent Synthesis of Highly Functionalized Polycyclic N‐Fused‐Pyrrolidine Heterocycles

“…As a central skeleton of numerous alkaloids or pharmacologically important compounds, polycyclic N ‐fused‐pyrrolidine is composed of multiple pyrrole‐type five‐ or six‐membered condensed rings (Figure ). Furthermore, functionalized N ‐fused polycyclic pyrrolidines form the core of numerous heterocyclic compounds that show a wide spectrum of anti‐tubercular, anti‐tumor, anti‐microbial, anti‐HIV, anti‐malarial, and anti‐diabetic . Not surprisingly, this structural unit has attracted much attention in the field of organic synthesis and pharmaceutical chemistry…”

Formation of spiro[indene-2,3′-pyrazole] derivatives from hydrazonyl chlorides and ninhydrin-malononitrile adduct

“…Spiroheterocycles are of considerable interest because the conformational restriction associated with the structural rigidity affects considerably their biological activity [1][2][3][4]. Among them, spiro-pyrazoles are the central structural frame works which are present in numerous bioactive natural products and alkaloids with biological and clinical activities [5][6][7][8].…”