Rhodium(III)‐Catalyzed Cyclative Capture Approach to Diverse 1‐Aminoindoline Derivatives at Room Temperature

Abstract

A Rh(III) -catalyzed C-H activation/cyclative capture approach, involving a nucleophilic addition of C(sp(3) )-Rh species to polarized double bonds is reported. This constitutes the first intermolecular catalytic method to directly access 1-aminoindolines with a broad substituent scope under mild conditions.

Photoredox Catalysis in Nickel-Catalyzed Cross-Coupling

“…The synthesis of these compounds generally relies on Pd-or Rh-catalyzed cyclization of alkenes with aryl halides [54] or C-H activation [55]. However, because of the ease of b-hydride elimination (Heck-type reaction) for the alkyl intermediate formed after alkene insertion, these methods often require strongly deactivating alkenes or alkenes bearing no b-hydrogen, thus limiting the utility of this transformation.…”

Microwave‐Assisted Rapid One‐Pot Synthesis of Fused and Non‐Fused Indoles and 5‐[18F]Fluoroindoles from Phenylazocarboxylates

“…Due to their importance, new synthetic methods are perpetually developed . Recently published strategies comprise the assembly of the indole moiety through cobalt‐,– rhodium‐,, or palladium‐catalyzed– reactions of such diverse starting materials as nitrones, azo esters, hydrazides,, nitrosoanilines, enamines, or imines . In addition to these developments, the classical Fischer indole synthesis is also constantly improved and remains attractive in medicinal chemistry and in natural products synthesis…”

Oxidative Olefination of Anilides with Unactivated Alkenes Catalyzed by an (Electron‐Deficient η5‐Cyclopentadienyl)Rhodium(III) Complex Under Ambient Conditions

“…However, these examples required stoichiometric external oxidants (or hydrogen acceptors) and/or elevated temperature. Consequently the development of the transition‐metal‐catalyzed oxidative sp 2 CH bond olefination of arenes with unactivated alkenes that proceeds under ambient conditions (at room temperature using air as a terminal oxidant) remains a challenge 16…”