2022
DOI: 10.1039/d2bm00309k
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Rhoifolin loaded in PLGA nanoparticles alleviates oxidative stress and inflammation in vitro and in vivo

Abstract: Rhoifolin (ROF) is a bioactive plant flavonoid with potent antioxidant and anti-inflammatory activity. However, no delivery system has yet been developed for ROF to overcome its biopharmaceutical limitations. The purpose...

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Cited by 22 publications
(15 citation statements)
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“…In brief, freshly prepared AmB@pQCT-PEG and AmB@pQCT NPs were each drop-cast on precleaned TiO 2 -coated Si wafers. The wafers were dried under vacuum and analyzed using a Kratos Axis SUPRA instrument fitted with a monochromated Al kα X-ray source (1486.7 eV) as previously described …”
Section: Methodsmentioning
confidence: 99%
“…In brief, freshly prepared AmB@pQCT-PEG and AmB@pQCT NPs were each drop-cast on precleaned TiO 2 -coated Si wafers. The wafers were dried under vacuum and analyzed using a Kratos Axis SUPRA instrument fitted with a monochromated Al kα X-ray source (1486.7 eV) as previously described …”
Section: Methodsmentioning
confidence: 99%
“…PLGA nanospheres for instance are phagocytosed by DCs, and when loaded with antitumor peptides, they trigger a significant specific cytotoxic T cells anticancer response at a lower concentration compared to peptides administered through incomplete Freund’s adjuvant . Nanoprecipitation, emulsification, and self-assembly are among the commonly applied methods for the preparation of PNPs. , While nanoprecipitation (Figure A) is characterized by its simplicity and reproducibility, it is a troublesome technique to optimize since the adjustment of solvent, cargo, and polymer ratios is critical . Emulsification (Figure B) allows for the loading of both hydrophilic and hydrophobic cargos, yet the entrapment efficiency is greatly limited .…”
Section: Polymer-based Nps As Cancer Vaccine Platformsmentioning
confidence: 99%
“…12 To improve the biocompatibility, targeting and pharmacological effects of TPs, some kinds of nanoformulations to load TPs have been synthesized and they have demonstrated good biosafety in vivo. [13][14][15][16] In this work, to improve the bioavailability and facilitate the delivery of TPs to the inflammatory sites, poly(lactic-co-glycolic acid) (PLGA) nanoparticles 17 were employed to load TPs to form TP-NPs. Then, platelet membranes (PMs) were isolated from the blood of healthy mice and coated onto the TP-NPs to endow PM@TP-NPs with inflammation targeting properties.…”
Section: Introductionmentioning
confidence: 99%
“…In this work, to improve the bioavailability and facilitate the delivery of TPs to the inflammatory sites, poly(lactic- co -glycolic acid) (PLGA) nanoparticles 17 were employed to load TPs to form TP-NPs. Then, platelet membranes (PMs) were isolated from the blood of healthy mice and coated onto the TP-NPs to endow PM@TP-NPs with inflammation targeting properties.…”
Section: Introductionmentioning
confidence: 99%