Rhombencéphalite liée au virus respiratoire syncytial chez un garçon de 7 ans

Tison-Chambellan, Camille; Cheuret, Emmanuel; Cances, C.; Karsenty, C.; Camus, Celine; Sévely, A; Chaix, Yves

doi:10.1016/j.arcped.2013.03.005

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…Among these infants, the patients infected with hRSV presented facial palsy and hemiplegia [77]. To date, several reports indicate that the infection with hRSV on infants can lead to the development of ataxia, febrile or epileptic state, encephalitis, and encephalopathies, among other symptoms [19,[78][79][80][81]. Among these patients with neurological symptoms, the genetic material of hRSV was found on the cerebrospinal fluid (CSF) and presented elevated cytokines [82,83].…”

Section: Neurological Consequences Due To Hrsv Infectionmentioning

confidence: 99%

Potential Neurocognitive Symptoms Due to Respiratory Syncytial Virus Infection

2021

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Respiratory infections are among the major public health burdens, especially during winter. Along these lines, the human respiratory syncytial virus (hRSV) is the principal viral agent causing acute lower respiratory tract infections leading to hospitalization. The pulmonary manifestations due to hRSV infection are bronchiolitis and pneumonia, where the population most affected are infants and the elderly. However, recent evidence suggests that hRSV infection can impact the mother and fetus during pregnancy. Studies have indicated that hRSV can infect different cell types from the placenta and even cross the placenta barrier and infect the fetus. In addition, it is known that infections during the gestational period can lead to severe consequences for the development of the fetus due not only to a direct viral infection but also because of maternal immune activation (MIA). Furthermore, it has been described that the development of the central nervous system (CNS) of the fetus can be affected by the inflammatory environment of the uterus caused by viral infections. Increasing evidence supports the notion that hRSV could invade the CNS and infect nervous cells, such as microglia, neurons, and astrocytes, promoting neuroinflammation. Moreover, it has been described that the hRSV infection can provoke neurological manifestations, including cognitive impairment and behavioral alterations. Here, we will review the potential effect of hRSV in brain development and the potential long-term neurological sequelae.

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Section: Neurological Consequences Due To Hrsv Infectionmentioning

confidence: 99%

Potential Neurocognitive Symptoms Due to Respiratory Syncytial Virus Infection

2021

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“…A total of 27 case reports were ultimately identified [ 91 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 ]. As five observational studies included clinical data that allowed the appropriate characterization of individual cases [ 52 , 55 , 81 , 83 , 119 ], a total of 84 cases of RSV-related encephalopathy/encephalitis were ultimately included in the analyses.…”

Section: Resultsmentioning

confidence: 99%

Occurrence of Central Nervous System Complications of Respiratory Syncytial Virus Infections: A Systematic Review with Meta-Analysis

Riccò,

Cascio,

Corrado

et al. 2024

Epidemiologia

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An increasing base of evidence suggests that respiratory syncytial virus (RSV) infections may be associated with neurological complications. In accord with the PRISMA statement, we performed a systematic review and meta-analysis on the occurrence of encephalitis and encephalopathy associated with documented RSV infections. PubMed, Embase, and Scopus databases were searched for eligible observational studies published up to 10 April 2024. Raw data included the occurrence of RSV infections among cases of encephalitis and/or encephalopathy and cases of encephalitis and/or encephalopathy among series of RSV infections. Data were pooled in a random effects model. Case reports were also collected, and their data pooled as a cumulative series. Heterogeneity was assessed using the I2 measure, while reporting bias was assessed by means of funnel plots and regression analysis. A total of 15 studies for a total of 7719 RSV infections and 1631 cases of encephalitis were analyzed. Moreover, 27 case reports and case series were retrieved, for a total of 84 individual cases of encephalitis/encephalopathy occurring during a documented RSV infection. A pooled prevalence of 2.20 cases of encephalitis/encephalopathy per 100 RSV cases (I2 = 99%) was calculated, while a prevalence of RSV infections among cases of encephalitis/encephalopathy was estimated to 3.53 per 100 cases for studies on respiratory specimens (I2 = 48%) and 0.37 per cases on central nervous system (CNS) specimens (I2 = 0%). Detection of RSV within the CNS was relatively rare (17.86% of pooled case reports), being associated with male gender (adjusted odds ratio [aOR] 5.021, 95% confidence interval [95%CI] 1.104 to 22.831) and recovery with long-term sequelae (aOR 5.699, 95%CI 1.152; 28.183). Case fatality ratio was estimated to be 0.43 per 100 cases on observational studies and 10.71% in case reports, a difference likely due to publication bias. In summary, RSV represented a not frequent but notable cause of encephalitis/encephalopathy in adults and children. The paucity of available studies not only recommends a cautious appraisal of our results but stresses the clinical significance of future studies on incident cases of encephalitis and/or encephalopathy.

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