Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome

Wu, Chao; Bian, Yanqin; Lu, Bingjie; Wang, Dan; Azami, Nisma Lena Bahaji; Wei, Gang; Ma, Feng; Sun, Mingyu

doi:10.1186/s12967-022-03495-4

Cited by 23 publications

(8 citation statements)

References 45 publications

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“…Clinical and experimental evidence has demonstrated that antioxidant compounds, both hydrophobic and hydrophilic, exhibit promising effects on liver injury . In animal and clinical studies, the antioxidant compound rhein has been widely used to treat liver-related diseases . However, hydrophobic rhein typically has poor solubility, is easily degraded, has a short half-life, has low bioavailability, or has nonspecific organ toxicity. , Moreover, as an active antioxidant, rhein has been reported to have a protective effect on the liver, while other studies have shown that rhein has potential hepatorenal toxicity, indicating that rhein has bidirectional regulatory effects on liver disease .…”

Section: Discussionmentioning

confidence: 99%

A Biomimetic Multifunctional Nanoframework for Symptom Relief and Restorative Treatment of Acute Liver Failure

Feng,

Fan,

Zhang

et al. 2024

ACS Nano

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Acute liver failure (ALF) is a rare and serious condition characterized by major hepatocyte death and liver dysfunction. Owing to the limited therapeutic options, this disease generally has a poor prognosis and a high mortality rate. When ALF cannot be reversed by medications, liver transplantation is often needed. However, transplant rejection and the shortage of donor organs still remain major challenges. Most recently, stem cell therapy has emerged as a promising alternative for the treatment of liver diseases. However, the limited cell delivery routes and poor stability of live cell products have greatly hindered the feasibility and therapeutic efficacy of stem cell therapy. Inspired by the functions of mesenchymal stem cells (MSCs) primarily through the secretion of several factors, we developed an MSC-inspired biomimetic multifunctional nanoframework (MBN) that encapsulates the growth-promoting factors secreted by MSCs via combination with hydrophilic or hydrophobic drugs. The red blood cell (RBC) membrane was coated with the MBN to enhance its immunological tolerance and prolong its circulation time in blood. Importantly, the MBN can respond to the oxidative microenvironment, where it accumulates and degrades to release the payload. In this work, two biomimetic nanoparticles, namely, rhein-encapsulated MBN (RMBN) and N-acetylcysteine (NAC)-encapsulated MBN (NMBN), were designed and synthesized. In lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced and acetaminophen (APAP)-induced ALF mouse models, RMBN and NMBN could effectively target liver lesions, relieve the acute symptoms of ALF, and promote liver cell regeneration by virtue of their strong antioxidative, anti-inflammatory, and regenerative activities. This study demonstrated the feasibility of the use of an MSC-inspired biomimetic nanoframework for treating ALF.

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Section: Discussionmentioning

confidence: 99%

A Biomimetic Multifunctional Nanoframework for Symptom Relief and Restorative Treatment of Acute Liver Failure

Feng,

Fan,

Zhang

et al. 2024

ACS Nano

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“…Moreover, a total of eight PM-derived monomers that entered the mitochondria of MAFLD rats treated with PM extract were successfully identified by mitochondrial pharmacochemistry, including five prototype components (AE, ED, EG, THSG, and TCS), and three of their metabolites (emodin-glucuronide, emodin-8-O-β-D-glucopyranoside reduction metabolite, and torachrysone-glucuronide). Four monomers have been reported to cure MAFLD, and include AE[ 22 , 23 ], ED[ 22 , 24 , 25 ], EG[ 26 ], and THSG[ 27 ]. Our data also show that TCS improved oxidative stress and energy production to prevent steatosis in L02 adipocytes induced by fat emulsion.…”

Section: Discussionmentioning

confidence: 99%

In vivo recognition of bioactive substances of Polygonum multiflorum for regulating mitochondria against metabolic dysfunction-associated fatty liver disease

Yu¹,

Li²,

Wang³

et al. 2023

World J Gastroenterol

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BACKGROUND Metabolic dysfunction-associated fatty liver disease (MAFLD) is a severe threat to human health. Polygonum multiflorum (PM) has been proven to remedy mitochondria and relieve MAFLD, but the main pharmacodynamic ingredients for mitigating MAFLD remain unclear. AIM To research the active ingredients of PM adjusting mitochondria to relieve high-fat diet (HFD)-induced MAFLD in rats. METHODS Fat emulsion-induced L02 adipocyte model and HFD-induced MAFLD rat model were used to investigate the anti-MAFLD ability of PM and explore their action mechanisms. The adipocyte model was also applied to evaluate the activities of PM-derived constituents in liver mitochondria from HFD-fed rats (mitochondrial pharmacology). PM-derived constituents in liver mitochondria were confirmed by ultra-high-performance liquid chromatography/mass spectrometry (mitochondrial pharmacochemistry). The abilities of PM-derived monomer and monomer groups were evaluated by the adipocyte model and MAFLD mouse model, respectively. RESULTS PM repaired mitochondrial ultrastructure and prevented oxidative stress and energy production disorder of liver mitochondria to mitigate fat emulsion-induced cellular steatosis and HFD-induced MAFLD. PM-derived constituents that entered the liver mitochondria inhibited oxidative stress damage and improved energy production against cellular steatosis. Eight chemicals were found in the liver mitochondria of PM-administrated rats. The anti-steatosis ability of one monomer and the anti-MAFLD activity of the monomer group were validated. CONCLUSION PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.

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“…the assembly of NLRP3 inflammatory bodies [81]. It was found that emodin inhibited the activation of HSCs by inhibiting the mRNA expression of TGF-β1, Smad4 and α-SMA [82].…”

Section: Calycosinmentioning

confidence: 99%

Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis

Li,

Chen,

et al. 2023

Molecules

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Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent chronic liver disorder worldwide, with liver fibrosis (LF) serving as a pivotal juncture in NAFLD progression. Natural products have demonstrated substantial antifibrotic properties, ushering in novel avenues for NAFLD treatment. This study provides a comprehensive review of the potential of natural products as antifibrotic agents, including flavonoids, polyphenol compounds, and terpenoids, with specific emphasis on the role of Baicalin in NAFLD-associated fibrosis. Mechanistically, these natural products have exhibited the capacity to target a multitude of signaling pathways, including Hedgehog, Wnt/β-catenin, TGF-β1, and NF-κB. Moreover, they can augment the activities of antioxidant enzymes, inhibit pro-fibrotic factors, and diminish fibrosis markers. In conclusion, this review underscores the considerable potential of natural products in addressing NAFLD-related liver fibrosis through multifaceted mechanisms. Nonetheless, it underscores the imperative need for further clinical investigation to authenticate their effectiveness, offering invaluable insights for future therapeutic advancements in this domain.

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Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome

Cited by 23 publications

References 45 publications

A Biomimetic Multifunctional Nanoframework for Symptom Relief and Restorative Treatment of Acute Liver Failure

A Biomimetic Multifunctional Nanoframework for Symptom Relief and Restorative Treatment of Acute Liver Failure

In vivo recognition of bioactive substances of Polygonum multiflorum for regulating mitochondria against metabolic dysfunction-associated fatty liver disease

Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis

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