Rhupus; unusual presentations

Shovman, Ora; Langevitz, Pnina; Shoenfeld, Yehuda

doi:10.1007/s10067-015-2978-y

Cited by 13 publications

(11 citation statements)

References 30 publications

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“…The positivity of autoantibodies is necessary for a diagnosis. According to the literature, anti-dsDNA and anti-CCP antibodies are found with high prevalence in rhupus syndrome (12). In our patient, most of the antibodies were positive.…”

Section: Discussionsupporting

confidence: 58%

“…Our patient had involvement in the knee and foot joints. Visceral organ damage in rhupus syndrome such as glomerulonephritis and serositis is less common than in SLE (12). The positivity of autoantibodies is necessary for a diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Low to moderate doses of corticosteroids with methotrexate are generally used in treatment with joint involvement (6). Other drugs such as mycophenolate mofetil, cyclosporin A, and tumor necrosis factor inhibitors have shown little effect on rhupus syndrome (12).…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of the disease is 0.09% (5). This syndrome's prevalence among systemic rheumatic diseases is estimated to be between 0.01 and 2% (12). The prognosis in rhupus syndrome depends on internal organ damage, but it is better than SLE and worse than RA.…”

Section: Introductionmentioning

confidence: 99%

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Rhupus syndrome: a case report

Akpinar

Yalçın²

2017

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rhupus syndrome: a case report

Akpinar

Yalçın²

2017

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…Rhupus syndrome is a rare clinical condition; only a few cases have been reported. The syndrome constitutes 0.01-2% of all systemic rheumatic disease (3). Vasculitis reported in 10-40% of SLE patients, usually as small vessel vasculitis.…”

Section: S Ystemic Lupus Erythematosus (Sle)mentioning

confidence: 99%

Systemic vasculitis in a patient with rhupus syndrome

et al. 2016

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summary Rhupus is a rare syndrome characterized by overlap of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Previous reports mentioned that rhupus patients have prominent RA associated clinical manifestations and only mild organic damage related to SLE. Progressive or life-threatening manifestations are rare in rhupus patients. Our patient diagnosed as rhupus was a young women, presented with multi-organ involvement of systemic vasculitis. Rheumatologists should be aware of possibility that rhupus may be accompanied by progressive or life-threatening conditions such as vasculitis.Key words: Rhupus; vasculitis; systemic lupus erythematosus; rheumatoid arthritis. Reumatismo, 2015; 67 (4): 161-164 n IntroductIon S ystemic lupus erythematosus (SLE) that is co-morbid with rheumatoid arthritis (RA) is known as rhupus syndrome (1). The overlap of RA and SLE was first described by Schur, in 1971, as rhupus (2). Rhupus syndrome is a rare clinical condition; only a few cases have been reported. The syndrome constitutes 0.01-2% of all systemic rheumatic disease (3). Vasculitis reported in 10-40% of SLE patients, usually as small vessel vasculitis. Vasculitis also seen in RA, but rheumatoid vasculitis is an unusual complication of long-standing RA. Here, we report the case of a young female with fulminant vasculitis and Rhupus syndrome; this is first example of such a disease overlap.n cASE rEPort A 28-year-old female patient was admitted complaining of pain in both ankles, both knees, and the metacarpophalangeal (MCP) and wrist joints, as well as bluish discoloration of the toes. She reported that the pain and swelling in both her hand and feet joints had been of almost 1 year in duration, and that the Raynaud's phenomenon in the toes had become especially notable over the past 10 days. She had no comorbidity. On physical examination, the dorsalis pedis pulses were bilaterally weak; both ankles, knees, and wrists, and all MCP joints, were painful; and swelling and alopecia were evident. The laboratory data were: hemoglobin 11.2 g/dL, mean corpuscular volume 88 fL, mean corpuscular hemoglobin 30.5 pg, leukocytes 12,500/ mm³, eosinophils 120/mm³ (normal range 100-450/mm³), platelets 512,000/mm³, urea 36 mg/dL, creatinine 0.5 mg/dL, aspartate aminotransferase 37 IU/L, alanine aminotransferase 48 IU/L, and C-reactive protein 168 mg/dL (normal range 0-5 mg/ dL). The erythrocyte sedimentation rate was 140 mm/h (normal range 1-20 mm/h). The rheumatoid factor (RF) level was 256 IU/mL (normal range 0-15 IU/mL) and the anti-citrullinated cyclic peptide antibody (anti-CCP) level 123 IU/mL (normal range 0-15 IU/mL). The serum was positive for antinuclear antibody (ANA) (titer 1:320; normal <1/80), anti-dsDNA antibody (titer >1:300; normal 0-20); and anti

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