Rhus chinensis Mill. fruits prevent necrotizing enterocolitis in rat pups via regulating the expressions of key proteins involved in multiple signaling pathways

Zhang, Yi; Wang, Ou; Mi, Hongying; Yi, Junjie; Cai, Shengbao

doi:10.1016/j.jep.2022.115103

Cited by 8 publications

(20 citation statements)

References 55 publications

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“…A PRISMA flow chart of screening and selection results is shown in Figure 1 . The initial search identified 544 articles of which 16 studies [ 25 , 27 , 28 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ] ( n = 610) were included after application of the selection criteria. Two studies were excluded because they evaluated a genetically engineered analogue of plant-derived substance [ 26 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

“…The median (IQR) sample size was 36 (10). NEC was induced by Hypoxia-reoxygenation and hypothermia ( n = 8) [ 27 , 28 , 34 , 36 , 39 , 40 , 44 , 45 ], hypoxia-reoxygenation ( n = 1) [ 37 ], hyperosmolar feeds, hypoxia-reoxygenation and hypothermia ( n = 1) [ 35 ], LPS administration, hyperosmolar formula feed, hypoxia-reoxygenation and hypothermia ( n = 1) [ 43 ], LPS administration, hypoxia-reoxygenation and hypothermia ( n = 2) [ 25 , 33 ], LPS administration and hypoxia-reoxygenation ( n = 2) [ 41 , 42 ], and acetic acid enema ( n = 1) [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…Age at euthanasia of animals: Rodents were euthanised on day 4 in eleven of the included studies [ 25 , 27 , 33 , 34 , 35 , 37 , 39 , 40 , 43 , 44 , 45 ], day 5 in three included studies [ 36 , 41 , 42 ], and day 10 in one included study [ 38 ]. One study did not provide this information [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…Single vs. combination product: A single plant-derived substance was evaluated in 14 RCTs including sumac ( Rhus chinensis/Rhus coriaria ) [ 39 , 45 ], curcumin [ 28 , 40 ], fennel extract [ 43 ], sesamol [ 35 ], berberine [ 38 , 41 ], ginger [ 25 ], quercetin [ 44 ], nigella sativa oil [ 27 ], pomegranate seed oil [ 36 ], astragaloside [ 34 ], and resveratrol [ 37 ]. The remaining two RCTs assessed a combination of plant-derived substances including Ankaferd Blood Stopper (containing Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum and Urtica dioica) [ 33 ] and daikenchuto (containing ginger, ginseng and zanthoxylum fruit) [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

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Plant-Derived Substances for Prevention of Necrotising Enterocolitis: A Systematic Review of Animal Studies

Mackay,

Rath,

Rao

et al. 2024

Nutrients

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Inflammation, oxidative injury, and gut dysbiosis play an important role in the pathogenesis of necrotising enterocolitis (NEC). Plant-derived substances have historically been used as therapeutic agents due to their anti-inflammatory, antioxidant, and antimicrobial properties. We aimed to review pre-clinical evidence for plant-derived substances in the prevention and treatment of NEC. A systematic review was conducted using the following databases: PubMed, EMBASE, EMCARE, MEDLINE and Cochrane Library (PROSPERO CRD42022365477). Randomized controlled trials (RCTs) and quasi-RCTs that evaluated a plant-derived substance as an intervention for NEC in an animal model of the illness and compared pre-stated outcomes (e.g., clinical severity, severity of intestinal injury, mortality, laboratory markers of inflammation and oxidative injury) were included. Sixteen studies (n = 610) were included in the systematic review. Ten of the sixteen included RCTs (Preterm rat pups: 15, Mice: 1) reported mortality and all reported NEC-related histology. Meta-analysis showed decreased mortality [12/134 vs. 27/135; RR: 0.48 (95% CI: 0.26 to 0.87); p = 0.02, 10 RCTs] and decreased NEC in the experimental group [24/126 vs. 55/79; RR: 0.34 (95% CI: 0.22 to 0.52); p < 0.001, 6 RCTs]. Markers of inflammation (n = 11) and oxidative stress (n = 13) improved in all the studies that have reported this outcome. There was no significant publication bias for the outcome of mortality. Plant-derived substances have the potential to reduce the incidence and severity of histologically diagnosed NEC and mortality in rodent models. These findings are helpful in guiding further pre-clinical studies towards developing a food supplement for the prevention of NEC in preterm infants.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Plant-Derived Substances for Prevention of Necrotising Enterocolitis: A Systematic Review of Animal Studies

Mackay,

Rath,

Rao

et al. 2024

Nutrients

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“…While the role of CRYZL1 is unclear, NQO1 protects against cellular damage by acting as a redox switch interacting with multiple proteins, mRNA, and NADH [55]. Upregulation of Nqo1 expression has been associated with protection from NEC-like injury in rats [56].…”

Section: Discussionmentioning

confidence: 99%

Improving Diagnostic Precision: Urine Proteomics Identifies Promising Biomarkers for Necrotizing Enterocolitis

Mackay,

Frazer,

Bailey

et al. 2024

Preprint

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BackgroundNecrotizing enterocolitis (NEC) is a severe intestinal disease that primarily impacts preterm infants. Current diagnostic tools are inadequate, so urine proteomics was performed for patients with and without NEC to identify putative biomarkers.Research design and methodsThe abundance of urinary proteins detected using an aptamer-based microarray was compared for infants with NEC (n=20) and controls, age-matched (n=8) or self-matched (n=12). Spearmanrcorrelation and hierarchical cluster analysis were performed. The area under the curve (AUC) was calculated for receiver operator characteristic curves (ROC).ResultsNinety-nine proteins differed in NEC vs. controls based on median fold change (Log2± 1.1) and significance (P< 0.05). Patterns of abundance were consistent for both types of matching, and samples clustered based on NEC severity. Two panels were built to differentiate between infants with and without NEC. Panel 1 included proteins associated with inflammation/NEC and produced by the intestinal epithelium (REG1B, REG3A, FABP2, DEFA5, AUC 0.90). Panel 2 consisted of proteins with the largest fold change between NEC vs. controls and the highest individual AUC values (REG1B, SSBP1, CRYZL1, ITM2B, IL36B, IL36RN, AUC 0.98).ConclusionsUrine proteins significantly differ between infants with and without NEC, which supports their potential as future biomarkers.Graphical abstract.Overview of study findings. Created with Biorender.com

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Phytochemical characteristics and biological activities of Rhus chinensis Mill.: a review

Zhang

et al. 2022

Current Opinion in Food Science

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Rhus chinensis Mill. fruits prevent necrotizing enterocolitis in rat pups via regulating the expressions of key proteins involved in multiple signaling pathways

Cited by 8 publications

References 55 publications

Plant-Derived Substances for Prevention of Necrotising Enterocolitis: A Systematic Review of Animal Studies

Plant-Derived Substances for Prevention of Necrotising Enterocolitis: A Systematic Review of Animal Studies

Improving Diagnostic Precision: Urine Proteomics Identifies Promising Biomarkers for Necrotizing Enterocolitis

Phytochemical characteristics and biological activities of Rhus chinensis Mill.: a review

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