Rhynchosia rufescens AgNPs enhance cytotoxicity by ROS-mediated apoptosis in MCF-7 cell lines

Khader, Syed Zameer Ahmed; Ahmed, Sidhra Syed Zameer; Ganesan, Gayathri Menon; Mahboob, Mohamed Rafi; Vetrivel, Manimaran; Sankarappan, Manavalan; Paulpandi, Manickam

doi:10.1007/s11356-019-06479-y

Cited by 20 publications

(10 citation statements)

References 33 publications

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“…It is assumed that these referred to the presence of reducing, and capping agent on the surface of the AgNps and the additional diffraction peaks in the XRD pattern were due to bio-organic crystallization in the plant extract. 27 These results were similar to those found in AgNps synthesized through mediation of other marine plants i.e. Ecklonia cava algae extract.…”

Section: Uv-vis Spectroscopy Analysissupporting

confidence: 83%

Marine plant mediated green synthesis of silver nanoparticles using mangrove Rhizophora stylosa: Effect of variable process and their antibacterial activity

et al. 2021

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Background: Most natural plants used in the synthesis of silver nanoparticles are limited to marine plants. To carry out applications, colloidal silver nanoparticles (AgNps) should have appropriate properties such as homogeneous shapes, small and narrow particle size distribution, and long time stability. This study aims to determine the effects of a variable process of AgNps mediated mangrove Rhizophora stylosa (RS) leaf extract, and antibacterial activity. Methods: Synthesis of AgNps was carried out by stirring silver nitrate solution with aqueous extract. The characterization of AgNps was carried out using UV-Vis spectrophotometry, X-ray diffraction (XRD), Dynamic Light Scattering (DLS) zetasizer and Transmission Electron Microscopy (TEM). Evaluation of antibacterial activity was carried out on Escherichia coli and Staphylococcus aureus. Reaction conditions such as the concentration of metal ions (0.001 M, 0.005 M, and 0.01 M), extracts (1%, 3%, and 5% v/v), and the reaction time on the size and stability of nanoparticles were also explored. Results: The UV-Vis spectroscopy showed an absorption of colloidal AgNps in a wavelength range of 403–443 nm. TEM analysis showed that as-synthesized AgNps were spherical in shape with a size range of 5–87 nm. The use of 0.001 M and 0.005 M of Ag+ resulted in a smaller diameter than the synthesized AgNps, using 0.01 M Ag+, in the same extract concentration. The range of zeta potential was -24.9 mV to -27.7 mV. The as-synthesized AgNps were stable for more than one month. The XRD analysis showed four peaks, which were attributed to the face centered cubic crystal structure of metallic silver. The results of the silver nanoparticles synthesis showed good activity on Escherichia coli and Staphylococcus aureus, with an inhibition zone between 4.1–7.2 mm. Conclusions: The AgNps synthesized with RS leaf extract, which is a reducing agent, showed good potential as an antibacterial component.

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Section: Uv-vis Spectroscopy Analysissupporting

confidence: 83%

Marine plant mediated green synthesis of silver nanoparticles using mangrove Rhizophora stylosa: Effect of variable process and their antibacterial activity

et al. 2021

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“…In order to understand whether cancer cell death is due to necrosis or apoptosis, we have stained cancer cells with DAPI (4 0 ,6-diamidine-2 0 -phenylindole dihydrochloride), which is considered as the marker for the apoptosis. [29][30][31][32] We have observed clear DNA disintegration and fragmentation in the cells treated with compounds (7i and 7g) with compared to untreated or control cells ( Fig. 1B and C).…”

Section: Nuclear Disintegrationmentioning

confidence: 74%

Newly synthesized 3-(4-chloro-phenyl)-3-hydroxy-2,2-dimethyl-propionic acid methyl ester derivatives selectively inhibit the proliferation of colon cancer cells

et al. 2020

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“…Research has proved that folklore medicines is regaining its prominence and being used by the community because of the fear of side effects (Syed et al 2019;Thangakumar et al 2019;Sidhra et al 2019) Fig. 3 exhibited the images of in vivo study on Albino Wistar rat models, which authenticate the wound healing ability of fabricated dressing materials.…”

Section: Effect Of Herbal Coated Fabric On Experimental Animal Modelmentioning

confidence: 85%

Fabrication and evaluation of bamboo fabric coated with extracts of Curcuma longa, Centella asiatica and Azadirachta indica as a wound dressing material

Ahmed¹,

Balu²,

Khader³

et al. 2020

ADV TRADIT MED (ADTM)

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Biomaterials are used on wounds as a dressing material to prevent the infection and to heal the wounds. In this present study, pure bamboo fabric has been selected for construction of functional part of bandage, coated with natural herbs such as Azadirachta indica, Centella asiatica, and Curcuma longa by microcapsules and exhaustion method. The binding of extracts to the fabric was confirmed through FTIR and FESEM analysis at 1 µm magnification. The air-permeability of the fabricate samples shows 100 cm 3 /cm 2 /s and the bursting strength was found to be 5.5 kg/cm 2 . The extension at break and recover of fabricated material was 101% and 24% respectively. The extract coated fabric expressed good water contact angle (50.51°-58.69°) and swelling property of about 337-320% at 10 mg/ml extract concentration. All fabrics exhibited good antibacterial activity against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, the major microbes present in the wounds. The prepared dressing material had shown only 20% degradation against lysozyme enzyme with no allergic reactions. Furthermore, wound healing ability of BFC-Cl, BFC-Ai and BFC-Ca were tested on Albino Wistar rats and found that extracts coated fabric took 15 days for complete healing of wound.

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Rhynchosia rufescens AgNPs enhance cytotoxicity by ROS-mediated apoptosis in MCF-7 cell lines

Cited by 20 publications

References 33 publications

Marine plant mediated green synthesis of silver nanoparticles using mangrove Rhizophora stylosa: Effect of variable process and their antibacterial activity

Marine plant mediated green synthesis of silver nanoparticles using mangrove Rhizophora stylosa: Effect of variable process and their antibacterial activity

Newly synthesized 3-(4-chloro-phenyl)-3-hydroxy-2,2-dimethyl-propionic acid methyl ester derivatives selectively inhibit the proliferation of colon cancer cells

Fabrication and evaluation of bamboo fabric coated with extracts of Curcuma longa, Centella asiatica and Azadirachta indica as a wound dressing material

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