Rhythmical slow wave electroencephalographic activity elicited by hippocampal injection of muscarinic agents in the rat

R, Malisch; Ott, Tilmann

doi:10.1016/0304-3940(82)90217-8

Cited by 21 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The selected doses of propranolol and SCH 23390 have been shown previously to be effective (Balschun et al, 1997;Seidenbecher et al, 1997). The used concentration of atropine was able to inhibit oxotremorine-induced hippocampal theta EEG activity (Malisch and Ott, 1982) (intraperitoneal application of 0.2 mg / kg oxotremorine sesquif umarate; data not shown). Application of the drugs 5 min (propranolol, SCH 23390, atropine) or 10 min (AP-5, 100 nmol, from RBI) after perforant path (PP) tetanization (control experiments without stimulation of the BL A) did not influence the time course of early LTP [for propranolol, see Seidenbecher et al (1997); other data not shown].…”

Section: Methodsmentioning

confidence: 70%

Reinforcement of Early Long-Term Potentiation (Early-LTP) in Dentate Gyrus by Stimulation of the Basolateral Amygdala: Heterosynaptic Induction Mechanisms of Late-LTP

et al. 2001

View full text Add to dashboard Cite

The basolateral amygdala (BLA) can influence distinct learning and memory formation. Hippocampal long-term potentiation (LTP), the most prominent cellular model of memory formation, can be modulated by stimulation of the BLA in its induction and early maintenance. However, it is not known how the late maintenance of LTP beyond its initial phases might be affected. Behavioral stimuli have been shown to result in a reinforcement of a transient early-LTP into a lasting potentiation. Here we show that BLA stimulation mimics the behavioral effects on early-LTP in freely moving rats when the BLA is activated within a time window of 30 min before or after tetanization of the perforant path. The reinforcement of LTP was blocked by inhibitors of muscarinergic and beta-adrenergic but not dopaminergic receptors and was dependent on translation. Through these heterosynaptic associative interactions, hippocampal sensory information can be stabilized by amygdaloidal influences.

show abstract

Section: Methodsmentioning

confidence: 70%

Reinforcement of Early Long-Term Potentiation (Early-LTP) in Dentate Gyrus by Stimulation of the Basolateral Amygdala: Heterosynaptic Induction Mechanisms of Late-LTP

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Electrical stimulation of the PO, following the microinfusion of atropine, failed to induce either HPC 0 field activity or concomitant rhythmic discharges of the MShDBB phasic 8-on cells. HPC 0 field activity has been shown to occur in response to microinfusions of cholinomimetics into the medial septum (Monmaur andBreton, 1991: Lawson and and the HPC itself (Malisch and Ott, 1982;Rowntree and Bland, 1986). Taken together with the data reported above for the PO and PH, an important conclusion is that the major cellular components of the ascending brainstem synchronizing pathway extrinsic to the HPC and including the intrinsic cellular components in the HPC itself are either cholinoceptive, cholinergic, or both.…”

Section: Microinfusion Of Carbachol Into the Po Or Phmentioning

confidence: 90%

Extrinsic modulation of medial septal cell discharges by the ascending brainstem hippocampal synchronizing pathway

et al. 1994

View full text Add to dashboard Cite

Single cells or simultaneously recorded cell pairs in the medial septum (MS) vertical limb of the diagonal band of Broca (vDBB) in the urethane-anesthetized rat were initially classified as either theta-on or non-related according to the system of Colom and Bland (1987, Brain Res 422:277-286). Subgroups of these cells were then studied under various test conditions that included electrical stimulation of the nucleus pontis oralis (PO) or posterior hypothalamus (PH), microinfusion of carbachol into the PO or PH, and the microinfusion of atropine sulfate or procaine hydrochloride into the PH. Electrical stimulation of either the PO or PH induced theta (theta) activity in the hippocampal formation (HPC), and electrical stimulation of the PO resulted in a simultaneous increase in the discharge rate of all MS/vDBB theta-on cells tested, compared to the rates recorded during HPC large-amplitude irregular activity (LIA). Five of the MS/vDBB theta-on cells were tested consecutively with electrical stimulation of the PO and PH, and were shown to be activated in a similar manner in either condition. Microinfusion of carbachol into either the PO or PH resulted in the induction of HPC theta field activity and the simultaneous intense activation of all MS/vDBB theta-on cells tested. Following the microinfusion of either atropine sulfate or procaine into the PH, electrical stimulation of the PO failed to induce HPC theta field activity or the concomitant rhythmic discharges of all MS/vDBB phasic theta-on cells tested. Microinfusing procaine into the PH also abolished the coupling between all MS/vDBB cell pairs during HPC theta field activity including that between two cell pairs that were coupled during HPC LIA. The data support the following conclusions: 1) The brainstem HPC synchronizing pathway originating in the pons region ascends to the medial septum via the midline posterior hypothalamic region; 2) the present results taken together with previous work suggest that a major component of the ascending synchronizing pathway, up to and including the hippocampal formation, is cholinergic, cholinoceptive, or both, and the receptors involved are primarily muscarinic; 3) the midline posterior hypothalamic region is an important source of inputs to the medial septum and their major contribution is to provide frequency-coded inputs to the MS/vDBB for relay into the hippocampal formation.

show abstract

“…Rowntree and Bland (1986) demonstrated that intrahippocampal infusions of carbachol resulted in continuous trains of hippocampal theta and that this theta was abolished by subsequent intrahippocampal microinfusions of atropine sulphate in urethane-anesthetized rats. Malisch and Ott (1982) had previously shown that hippocampal theta could be elicited in freely moving rats following intrahippocampal injections of various muscarinic agents.…”

Section: The Effect Of Electrical Stimulation Of the Po And Ph On Hpcmentioning

confidence: 99%

The midline posterior hypothalamic region comprises a critical part of the ascending brainstem hippocampal synchronizing pathway

et al. 1994

View full text Add to dashboard Cite

Electrical stimulation and microinfusion techniques were utilized in acute experiments on urethane-anesthetized rats in order to evaluate the hypothesis that the posterior hypothalamic and supramammillary nuclei comprise a critical part of the ascending brainstem pathway for producing synchronous hippocampal formation (HPC) field activity (theta). Given confirmation of this hypothesis a second objective was to determine the nature of the contribution made by this midline posterior hypothalamic region (PH) to the frequency and amplitude components of HPC theta field activity. The cholinergic nature of the ascending pathway was also examined. Reversible inactivation of the PH was achieved by microinfusion of the local anesthetic procaine hydrochloride. The efficacy of and recovery from procaine inactivation of the PH was quantitatively analyzed either by electrical stimulation of the nucleus pontis oralis (PO) (two experiments) or the PH (four experiments). The results are summarized under the following three headings: 1) The first is the effect of procaine inactivation of the PH on HPC theta elicited caudal to, at the level of, or rostral to the PH. All HPC theta induced caudal to the PH (spontaneous theta, tail pinch-induced theta, and theta produced by electrical stimulation of the PO) was totally abolished for a minimum 10-min period. HPC theta induced rostral to the PH by the intrahippocampal infusion of carbachol was unaffected, while HPC theta induced by infusions of carbachol into either the medial septum (MS) or PH was reduced in amplitude with no effect on frequency. 2) Next are comparisons of pre- and post-PH procaine trials of electrical stimulation of the PO and PH. In all experiments, regardless of the anatomical locus or technique used to induce HPC theta, pre- and post-PH procaine comparisons of the PO and PH stimulation trials revealed that frequency modulation of HPC theta recovered significantly more slowly than amplitude. 3) Last is the effect of electrical stimulation of the PO and PH on HPC theta induced by carbachol infusions at the level of the HPC, MS, or PH. In all experiments, electrical stimulation of both the PO and PH, at appropriate intensities, resulted in increasing HPC theta frequencies above the frequency induced by the infusion of carbachol into the HPC, MS, and PH. In addition, the post-carbachol HPC theta frequencies induced by electrical stimulation were significantly higher than those produced in the pre-carbachol conditions.(ABSTRACT TRUNCATED AT 400 WORDS)

show abstract

Rhythmical slow wave electroencephalographic activity elicited by hippocampal injection of muscarinic agents in the rat

Cited by 21 publications

References 13 publications

Reinforcement of Early Long-Term Potentiation (Early-LTP) in Dentate Gyrus by Stimulation of the Basolateral Amygdala: Heterosynaptic Induction Mechanisms of Late-LTP

Reinforcement of Early Long-Term Potentiation (Early-LTP) in Dentate Gyrus by Stimulation of the Basolateral Amygdala: Heterosynaptic Induction Mechanisms of Late-LTP

Extrinsic modulation of medial septal cell discharges by the ascending brainstem hippocampal synchronizing pathway

The midline posterior hypothalamic region comprises a critical part of the ascending brainstem hippocampal synchronizing pathway

Contact Info

Product

Resources

About