Rhythmicity of Mood Symptoms in Individuals at Risk for Psychiatric Disorders

Pilz, Luísa K.; Carissimi, Alícia; Oliveira, Melissa Alves Braga de; Francisco, Ana Paula; Fabris, Raul Costa; Medeiros, Madeleine Scop; Scop, Marina; Frey, Benício N.; Adán, Ana; Hidalgo, María Paz Loayza

doi:10.1038/s41598-018-29348-z

Cited by 21 publications

(22 citation statements)

References 41 publications

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“…Currently, extensive attention has been paid to the biological clock in the eld of psychiatry and psychology due to its importance. 6,[10][11][12]38,39 We hope that future research on optimizing the functions of the biological clock can develop a new area of "rhythmic medicine". If the circadian rhythm could be more effectively integrated with the warning, diagnosis and treatment of psychosomatic diseases, then, mental health might be improved, psychosomatic diseases prevented, and the therapeutic e cacy maximized.…”

Section: Synchronized Intervention Strategy For Rhythm Disruption Andmentioning

confidence: 99%

Disrupted Rhythms of Life, Work and Entertainment Behaviours and Their Associations with Mental Health Problems under the Stress of COVID-19 Epidemic: A Survey in 5854 Chinese People with Different Backgrounds

Yang¹,

He²,

Xu³

et al. 2020

Preprint

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BACKGROUND and OBJECTIVE The rhythms of life, work and entertainment behaviours are considered as the external behavioural manifestations of biological rhythm.To evaluate the distinctive disrupted rhythms of behaviours and their associations with mental health problems in people with different backgrounds under the stress of COVID-19 epidemic.SUBJECTS AND METHODS A cross-sectional study was conducted from 10-17 March 2020 under the stress of COVID-19 epidemic.A structured e-questionnaire containing general information,rhythm scale(subscale1 for life-work rhythms and subscale2 for entertainment rhythm) and Zung's self-rating depression and anxiety scale(SDS and SAS) were filled and the data were analysed.RESULTS Overall 5854 participants were included.Significant differences were found in rhythm, SDS and SAS scores among people with different backgrounds (all P<0.05). Subjects with female gender and poor health status were mostly suffered from disrupted rhythms of life- work-entertainment behaviours, combined with depression and anxiety. Nurses and subjects being divorced or with chronic disease with psychosomatic diseases were mostly suffered from disrupted rhythms of life-work behaviours, combined with depression and anxiety. Subjects with aged 26-30 years, or annual income of 50,000-100,000CY were mostly suffered from disrupted rhythms of life-work combined with depression. Subjects with income over 300,000CY were mostly suffered from disrupted rhythm of entertainment combined with anxiety.The prevalence rates of depression and anxiety in people with the high-scores of rhythm disruption increased by 34.50% and 47.16%, respectively, compared with those with low-scores.People with the high-scores of rhythm disruption had higher SDS and SAS scores, compared to those with low scores (all P<0.001). The independent related factors of disrupted rhythms included gender,age,marital status, health status,annual income and chronic diseases with psychosomatic diseases using logistic regression.The disrupted rhythms of life and work behaviours was positively correlated with both SDS and SAS scores.CONCLUSIONS The disrupted rhythms of life, work and entertainment behaviours were closely associated with mental health problems.The disrupted rhythms of behaviours are frequent and fluxible,triggering more severe mental health problems under the stress of COVID-19 epidemic.The physicians should be aware of their importance when evaluating their interviewees or patients’ mental health and achieving maximization of therapeutic efficacy by integrating the intervention of circadian rhythm and its behaviour.

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Section: Synchronized Intervention Strategy For Rhythm Disruption Andmentioning

confidence: 99%

Disrupted Rhythms of Life, Work and Entertainment Behaviours and Their Associations with Mental Health Problems under the Stress of COVID-19 Epidemic: A Survey in 5854 Chinese People with Different Backgrounds

Yang¹,

He²,

Xu³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Physiological stress is frequently associated with circadian disruption, and the regulation of the stress response system is one mechanism by which circadian rhythms are altered [91]. Thus, it is not surprising that disruptions in the circadian rhythms are a common symptom across stress-related psychiatric disorders [92]. Similar to the stress response system, the circadian clock is a well-conserved mechanism that allows organisms to adapt to their environment.…”

Section: Stress Response and Circadian Rhythmicitymentioning

confidence: 99%

Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease

Baker

Ozsan

Ospina

et al. 2018

IJMS

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The hypothalamus-pituitary-adrenal (HPA) axis directly controls the stress response. Dysregulation of this neuroendocrine system is a common feature among psychiatric disorders. Steroid hormone receptors, like glucocorticoid receptor (GR), function as transcription factors of a diverse set of genes upon activation. This activity is regulated by molecular chaperone heterocomplexes. Much is known about the structure and function of these GR/heterocomplexes. There is strong evidence suggesting altered regulation of steroid receptor hormones by chaperones, particularly the 51 kDa FK506-binding protein (FKBP51), may work with environmental factors to increase susceptibility to various psychiatric illnesses including post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety. This review highlights the regulation of steroid receptor dynamics by the 90kDa heat shock protein (Hsp90)/cochaperone heterocomplexes with an in depth look at how the structural regulation and imbalances in cochaperones can cause functional effects on GR activity. Links between the stress response and circadian systems and the development of novel chaperone-targeting therapeutics are also discussed.

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“…The original version of this instrument was created in Brazilian Portuguese [21], which was then translated and validated in Spanish [22,23]. In a large study with 708 participants that completed the MRhI, we found that the rhythmicity of specific mood-related symptoms and behaviors, such as pessimism and motivation to exercise were associated with higher risk for psychiatric disorders [24]. Notably, we also found specific cultural differences in comparing Spanish and Brazilian samples in terms of the daily patterns of moodrelated symptoms [25].…”

Section: Introductionmentioning

confidence: 99%

Validation of the English version of the Mood Rhythm Instrument

et al. 2020

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Background: Disruption of biological rhythms has been linked to the pathophysiology of mental disorders. However, little is known regarding the rhythmicity of mood symptoms due to the lack of validated clinical questionnaires. A better understanding of the rhythmicity of mood symptoms can help identifying individuals whose severity of mood symptoms follows an altered circadian rhythm. The objective of this study was to validate the English version of the Mood Rhythm Instrument (MRhI), a self-reported measure of self-perceived rhythmicity of mood symptoms and behaviours, in a sample of the general population from Canada. Methods: After the translation process, the final English version of the Mood Rhythm Instrument (MRhI-English) was applied on participants recruited at McMaster University and St. Joseph's Healthcare Hamilton campuses. Individuals were also asked to answer the Reduced Morningness-Eveningness Questionnaire (rMEQ). Results: Four hundred one individuals completed the English version of the MRhI and the rMEQ. The MRhI-English presented a Cronbach's alpha of 0.75. The factorial analysis grouped the MRhI-15 items in 3 factors (cognitive, affective and somatic), with affective items having a lower frequency of self-reported 24-h peaks. Comparison between sexes showed that women reported a higher frequency of daily peaks in irritability, anxiety, sadness and talking to friends, while men exhibited peaks more frequently in problem-solving, sexual arousal and motivation to exercise. Conclusions: Our findings suggest that the English version of the MRhI displayed good internal consistency. Future directions will include the use of the MRhI instrument in individuals with mood disorders, aiming to provide a better understanding of the relationship between daily patterns of mood variability and mental health outcomes.

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Rhythmicity of Mood Symptoms in Individuals at Risk for Psychiatric Disorders

Cited by 21 publications

References 41 publications

Disrupted Rhythms of Life, Work and Entertainment Behaviours and Their Associations with Mental Health Problems under the Stress of COVID-19 Epidemic: A Survey in 5854 Chinese People with Different Backgrounds

Disrupted Rhythms of Life, Work and Entertainment Behaviours and Their Associations with Mental Health Problems under the Stress of COVID-19 Epidemic: A Survey in 5854 Chinese People with Different Backgrounds

Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease

Validation of the English version of the Mood Rhythm Instrument

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