Rhythms of Mammalian Body Temperature Can Sustain Peripheral Circadian Clocks

Brown, Steven A.; Zumbrunn, Gottlieb; Fleury-Olela, Fabienne; Preitner, Nicolas; Schibler, Ueli

doi:10.1016/s0960-9822(02)01145-4

Cited by 530 publications

(415 citation statements)

References 38 publications

(8 reference statements)

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“…Nevertheless, these rhythms tended to fade away unless a stimulation (glucocorticoid, serum shock) or an environmental 24-h cycle (temperature, light) was introduced after a few days in culture, suggesting the need for a regular resetting of free-running peripheral oscillators in order for their coordination to be maintained (2,3,9,21,49). In rodents with lesioned SCN, a few transcriptional rhythms have been documented in vivo in peripheral tissues using DNA microarrays and very stringent amplitude criteria for rhythm detection (1,39).…”

Section: Discussionmentioning

confidence: 99%

Persistent twenty-four hour changes in liver and bone marrow despite suprachiasmatic nuclei ablation in mice

Filipski

King²,

Etienne³

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

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. Persistent twenty-four hour changes in liver and bone marrow despite suprachiasmatic nuclei ablation in mice. Am J Physiol Regul Integr Comp Physiol 287: R844 -R851, 2004. First published June 24, 2004 10.1152/ajpregu. 00085.2004.-Rest-activity or cortisol rhythms can be altered in cancer patients, a condition that may impair the benefits from a timed delivery of anticancer treatments. In rodents, the circadian pattern in rest-activity is suppressed by the destruction of the suprachiasmatic nuclei (SCN) in the hypothalamus. We sought whether such ablation would result in a similar alteration of cellular rhythms known to be relevant for anticancer drug chronopharmacology. The SCN of 77 B6D2F1 mice synchronized with 12 h of light and 12 h of darkness were destroyed by electrocoagulation [SCN(Ϫ)], while 34 animals were sham operated. Activity and body temperature were recorded by telemetry. Blood and organs were sampled at one of six circadian times for determinations of serum corticosterone concentration, blood leukocyte count, reduced glutathione (GSH), and dihydropyrimidine dehydrogenase (DPD) mRNA expression in liver and cell cycle phase distribution of bone marrow cells. Sham-operated mice displayed significant 24-h rhythms in rest-activity and body temperature, whereas such rhythms were found in none and in 15% of the SCN(Ϫ) mice, respectively. SCN lesions markedly altered the rhythmic patterns in serum corticosterone and liver GSH, which became nonsinusoidal. Liver DPD mRNA expression and bone marrow cell cycle phase distribution displayed similar 24-h sinusoidal patterns in shamoperated and SCN(Ϫ) mice. These results support the existence of another light-dark entrainable pacemaker that can coordinate cellular functions in peripheral organs. They suggest that the delivery of anticancer treatments at an optimal time of day may still be beneficial, despite suppressed rest-activity or cortisol rhythms. circadian coordination; cancer chronotherapeutics; cortisol; cell cycle; dihydropyrimidine dehydrogenase APPROXIMATELY 25% of cancer patients displayed profound alterations of rest-activity pattern and cortisol rhythm independently of tumor stage or general condition (32-34). Poorer tumor response and shorter survival were reported in these patients compared with those with near normal circadian function (36,43). Such altered circadian function could also impair the therapeutic benefit that can result from chronotherapeutics, i.e., the delivery of anticancer treatments at selected times of day (12,23,26,27).This treatment optimization method is based on the regulation of cellular metabolism and proliferation by a molecular clock. This clock consists of interconnected molecular loops involving up to 12 specific clock genes. It has been uncovered in most mammalian tissues (21,35,41,42) and rhythmically regulates the transcription of 5-10% of the genome (14,21,41,42). Indeed, sustained rhythms in transcription or other cellular functions have been demonstrated in cultured mammalian cells, giving rise to the con...

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Section: Discussionmentioning

confidence: 99%

Persistent twenty-four hour changes in liver and bone marrow despite suprachiasmatic nuclei ablation in mice

Filipski

King²,

Etienne³

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

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“…In mammals, temperature cycles contribute to the entrainment mechanisms of peripheral clocks. Schibler and colleagues demonstrated a few years ago that rhythmic temperature cycles maintain circadian cycles in fibroblasts (Brown et al, 2002). Interestingly, circadian changes in environmental temperatures were able to phase shift gene expression in the liver but not in the SCN.…”

Section: Synchronization Of the Liver Oscillator By Systemic Timing Cuesmentioning

confidence: 99%

The role of clock genes and rhythmicity in the liver

Schmutz

Albrecht

Ripperger

2012

Molecular and Cellular Endocrinology

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The liver is the important organ to maintain energy homeostasis of an organism. To achieve this, many biochemical reactions run in this organ in a rhythmic fashion. An elegant way to coordinate the temporal expression of genes for metabolic enzymes relies in the link to the circadian timing system. In this fashion not only a maximum of synchronization is achieved, but also anticipation of daily recurring events is possible. Here we will focus on the input and output pathways of the hepatic circadian oscillator and discuss the recently found flexibility of its circadian transcriptional networks.

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“…Both feeding rhythms and temperature cycles were shown to synchronize peripheral clocks and even uncouple them from the master clock in the brain (e.g., daytime restricted feeding), (Brown et al, 2002;Buhr et al, 2010;Damiola et al, 2000;Saini et al, 2012;Stokkan et al, 2001;Vollmers et al, 2009). Notably, both nutrient ingestion/processing and maintenance of body temperature are tightly linked to oxygen consumption.…”

Section: Introductionmentioning

confidence: 99%

Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1α

et al. 2017

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. AbstractThe mammalian circadian system consists of a master clock in the brain that synchronizes subsidiary oscillators in peripheral tissues. The master clock maintains phase coherence in peripheral cells through systemic cues such as feeding-fasting and temperature cycles. Here we examined the role of oxygen as a resetting cue for circadian clocks. We continuously measured oxygen levels in living animals and detected daily rhythms in tissue oxygenation. Oxygen cycles, within the physiological range, were sufficient to synchronize cellular clocks in HIF1α-dependent manner. Furthermore, several clock genes responded to changes in oxygen levels through HIF1α. Finally, we found that a moderate reduction in oxygen levels for a short period accelerates the adaptation of wild type but not of HIF1α-deficient mice to the new time in a jet lag protocol. We conclude that oxygen, via HIF1α activation, is a resetting cue for circadian clocks and propose oxygen modulation as therapy for jet lag.

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Rhythms of Mammalian Body Temperature Can Sustain Peripheral Circadian Clocks

Abstract: We postulate that both endogenous and environmental temperature cycles can participate in the synchronization of peripheral clocks in mammals.

Cited by 530 publications

References 38 publications

Persistent twenty-four hour changes in liver and bone marrow despite suprachiasmatic nuclei ablation in mice

Persistent twenty-four hour changes in liver and bone marrow despite suprachiasmatic nuclei ablation in mice

The role of clock genes and rhythmicity in the liver

Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1α

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