RI-WS-8 Fertilite apres embolisation des arteres uterines pour hemorragie de la delivrance

Maubon, A.; Hardeman, Stephen W.; Decroisette, E.; Pouquet, M.; Bouillet, Philippe; Vincelot, A.; Aubard, Y.

doi:10.1016/s0221-0363(09)76231-6

Cited by 3 publications

(2 citation statements)

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“…34 Remarkably, preclinical studies have reported that after 24 hours of cold ischemia, pregnancy was possible in mammals (mice). 59,60 It seems the uterus has an outstanding tolerance to ischemia compared with other organs; however, it is currently problematic to define a threshold in which the uterus is unlikely to be functional, especially during prolonged cold ischemia using DDs. 61,62 In this review, the total ischemia time for grafts that failed was 220 AE 68.2 minutes in comparison to a mean ischemia time of 167 AE 75 minutes reported for all grafts.…”

Section: Discussionmentioning

confidence: 99%

Evolution and Transformation of Uterine Transplantation: A Systematic Review of Surgical Techniques and Outcomes

Escandón

Bustos

Santamaría

et al. 2021

J Reconstr Microsurg

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Background Uterine transplantation (UTx) is acknowledged to be on the second (2A) of five steps of development in accordance with the staging system for the evaluation of surgical innovations. Accordingly, we aimed to systematically review the available evidence of the surgical techniques and outcomes of UTx in terms of graft survival. Methods A comprehensive search was conducted across PubMed Medline, Cochrane-EBMR, Scopus, Web of Science, and CENTRAL through November 2020. Results Forty studies, reporting 64 recipients and 64 donors, satisfied inclusion criteria. The surgical time and the estimated blood loss were 515 minutes and 679 mL for graft procurement via laparotomy, 210 minutes and 100 mL for laparoscopic-assisted graft harvest, and 660 minutes and 173 mL for robotic-assisted procedures, respectively. Urinary tract infections (n = 8) and injury to the urinary system (n = 6) were the most common donor complications. Using the donor's internal iliac system, two arterial anastomoses were performed in all cases. Venous outflow was accomplished through the uterine veins (UVs) in 13 cases, a combination of the UVs and the ovarian/uteroovarian veins (OVs/UOVs) in 36 cases, and solely through the OVs/UOVs in 13 cases. Ischemia time was 161 and 258 minutes when using living donors (LD) and deceased donors (DD), respectively. Forty-eight uteri were successfully transplanted or fulfilled the purpose of transplantation, 41 from LDs and 7 from DDs. Twenty-five and four live childbirths from LDs and DDs have been reported, respectively. Conclusion UTx is still experimental. Further series are required to recommend specific surgical techniques that best yield a successful transplant and reduce complications for donors and recipients.

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Section: Discussionmentioning

confidence: 99%

Evolution and Transformation of Uterine Transplantation: A Systematic Review of Surgical Techniques and Outcomes

Escandón

Bustos

Santamaría

et al. 2021

J Reconstr Microsurg

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“…Published data for UTx show that the human uterus can tolerate a period of CI up to 6 h at least, permitting a favorable pregnancy outcome [60]. Before the development of UTx, studies of uterine embolization, particularly in cases of post-partum hemorrhage, showed that the uterus could tolerate a transient period of ischemia, with the subsequent achievement of pregnancies, and no consequences for fertility [63,64]. In the framework of UTx, data from animals also seem to indicate a high tolerance to ischemia.…”

Section: Discussionmentioning

confidence: 99%

The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review

Tardieu

Dion

Lavoué

et al. 2019

JCM

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Introduction: Uterus transplantation (UTx) is a promising treatment for uterine infertility that has resulted in several births since 2014. Ischemia is a key step in organ transplantation because it may lead to changes jeopardizing graft viability. Method: We performed a systematic review of animal and human studies relating to uterine ischemia. Results: We retained 64 studies published since 2000. There were 35 studies in animals, 24 in humans, and five literature reviews. Modest preliminary results in large animals and humans are limited but encouraging. In small animals, pregnancies have been reported to occur after 24 h of cold ischemia (CI). In ewes, uterine contractions have been detected after 24 h of CI. Furthermore, it has been shown in animals that uterine tolerance to CI and to warm ischemia (WI) can be increased by pharmacological products. In women, mean CI time in studies of births from uteri obtained from live donors was between 2 h 47 min and 6 h 20 min from a deceased donor; with only one birth in this case. Muscle contractions have also been demonstrated in myometrial samples from women, after six or more hours of CI. Conclusion: The uterus seems to be able to tolerate a prolonged period of CI, of at least six hours. Studies of the ischemia tolerance of the uterus and ways to improve it are essential for the development of UTx, particularly for procedures using grafts from deceased donors.

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Imagerie et radiologie interventionnelle chez la femme : nouveautés et perspectives

Tavolaro

Kermarrec

Bazot

et al. 2018

Imagerie de la Femme

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RI-WS-8 Fertilite apres embolisation des arteres uterines pour hemorragie de la delivrance

Cited by 3 publications

References 0 publications

Evolution and Transformation of Uterine Transplantation: A Systematic Review of Surgical Techniques and Outcomes

Evolution and Transformation of Uterine Transplantation: A Systematic Review of Surgical Techniques and Outcomes

The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review

Imagerie et radiologie interventionnelle chez la femme : nouveautés et perspectives

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