Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro

Abstract

Ribes fasciculatum var. chinense MAX. (R. fasciculatum) has traditionally been used in Korea to treat inflammatory diseases. However, the exact mechanism that accounts for the anti-inflammatory effect of R. fasciculatum is not completely understood. We aimed to ascertain the pharmacological effects of R. fasciculatum on both compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Additionally, to find a possible explanation for the anti-inflammatory effects of R. fasciculatum, we evaluated the effects of R. fasciculatum on the production of inflammatory mediators in LPS-stimulated macrophage cells. Treatment of R. fasciculatum significantly reduced compound 48/80- or histamine-induced the pruritus in mice. R. fasciculatum attenuated the AD symptoms such as eczematous, erythema and dryness and serum IgE levels in AD model. Additionally, R. fasciculatum inhibited the production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The maximal rates of TNF-α and IL-6 inhibition by R. fasciculatum (1 mg/ml) were approximately 32.12% and 46.24%, respectively. We also showed that R. fasciculatum inhibited the activation of nuclear factor-kappa B in LPS-stimulated macrophages. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of R. fasciculatum as a potential molecule for use in the treatment of allergic inflammatory diseases.

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

“…Male BALB/c mice were sensitized with 0.15% DNCB applied to the dorsal skin twice per week for five weeks; after three weeks, R. fasciculatum (200 mg/kg) was orally administered two weeks until the end of the experiment. Treatment of animals with R. fasciculatum extract significantly reduced the atopic dermatitis and IgE levels in serum induced by the application of DNCB [ 64 ].…”

Antiadipogenic Effects of Mixtures of Cornus officinalis and Ribes fasciculatum Extracts on 3T3-L1 Preadipocytes and High-Fat Diet-Induced Mice

“…Many studies demonstrate protective effects of CO on hepatitis, osteoporosis, oxidative stress and obesity [24][25][26]. Ribes fasciculatum (RF) is also a common alternative traditional medication against inflammatory conditions such as allergy, aging and autoimmunity in Asia [27][28][29]. Despite the beneficial effects of these natural plants, combination CO and RF extracts for weight loss have not been reported.…”

PDK1 in NF-κB signaling is a target of Xanthium strumarium methanolic extract-mediated anti-inflammatory activities

“…Interestingly, a selective COX-2 inhibitor (rofecoxib) has been shown to strongly reduce inflammatory symptoms in the stomachs of mice treated with HCl/EtOH (Jung et al, 2014), indicating that COX-2-generated PGE 2 can cause gastric ulcers in this model. Therefore, the ability of Xs-ME to inhibit NO and PGE 2 production and to downregulate the expression of iNOS and COX-2 ( Fig.…”

“…Most studies on inflammation have focused on the systemic, cellular, and molecular mechanisms of inflammatory responses (Hossen et al, 2015b). However, hyperactive and prolonged inflammation is known to cause various chronic diseases including cancer, diabetes, atherosclerosis, autoimmune disorders, arthritis, and vascular diseases (Ham and Moon, 2013;Jung et al, 2014;Kim et al, 2014a;Lyman et al, 2014;Momi et al, 2012). Therefore, preventing periodic upregulation of chronic inflammatory responses has been proposed as a potential strategy for preventing multiple diseases .…”