Ribosome-associated protein quality control: Implications for neurodegenerative diseases and therapeutic potential

Gao, Yajie; Zhu, Yuanxiang; Sun, Qinmiao; Chen, Dahua

doi:10.1016/j.scib.2024.01.021

Science Bulletin

2024

DOI: 10.1016/j.scib.2024.01.021

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Ribosome-associated protein quality control: Implications for neurodegenerative diseases and therapeutic potential

Yajie Gao,

Yuanxiang Zhu,

Qinmiao Sun

et al.

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Organellar quality control crosstalk in aging‐related disease: Innovation to pave the way

Li,

Qi,

Guo

et al. 2024

Aging Cell

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Organellar homeostasis and crosstalks within a cell have emerged as essential regulatory and determining factors for the survival and functions of cells. In response to various stimuli, cells can activate the organellar quality control systems (QCS) to maintain homeostasis. Numerous studies have demonstrated that dysfunction of QCS can lead to various aging‐related diseases such as neurodegenerative, pulmonary, cardiometabolic diseases and cancers. However, the interplay between QCS and their potential role in these diseases are poorly understood. In this review, we present an overview of the current findings of QCS and their crosstalk, encompassing mitochondria, endoplasmic reticulum, Golgi apparatus, ribosomes, peroxisomes, lipid droplets, and lysosomes as well as the aberrant interplays among these organelles that contributes to the onset and progression of aging‐related disorders. Furthermore, potential therapeutic approaches based on these quality control interactions are discussed. Our perspectives can enhance insights into the regulatory networks underlying QCS and the pathology of aging and aging‐related diseases, which may pave the way for the development of novel therapeutic targets.

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Organellar quality control crosstalk in aging‐related disease: Innovation to pave the way

Li,

Qi,

Guo

et al. 2024

Aging Cell

View full text Add to dashboard Cite

show abstract

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Ribosome-associated protein quality control: Implications for neurodegenerative diseases and therapeutic potential

Cited by 1 publication

References 20 publications

Organellar quality control crosstalk in aging‐related disease: Innovation to pave the way

Organellar quality control crosstalk in aging‐related disease: Innovation to pave the way

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