2024
DOI: 10.1093/narcan/zcae029
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Ribosome specialization in cancer: a spotlight on ribosomal proteins

Sofia Ramalho,
Anna Dopler,
William James Faller

Abstract: In the past few decades, our view of ribosomes has changed substantially. Rather than passive machines without significant variability, it is now acknowledged that they are heterogeneous, and have direct regulatory capacity. This ‘ribosome heterogeneity’ comes in many flavors, including in both the RNA and protein components of ribosomes, so there are many paths through which ribosome specialization could arise. It is easy to imagine that specialized ribosomes could have wide physiological roles, through the t… Show more

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