2010
DOI: 10.1186/1745-6150-5-60
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Riboswitches as hormone receptors: hypothetical cytokinin-binding riboswitches in Arabidopsis thaliana

Abstract: BackgroundRiboswitches are mRNA elements that change conformation when bound to small molecules. They are known to be key regulators of biosynthetic pathways in both prokaryotes and eukaryotes.Presentation of the HypothesisThe hypothesis presented here is that riboswitches function as receptors in hormone perception. We propose that riboswitches initiate or integrate signaling cascades upon binding to classic signaling molecules. The molecular interactions for ligand binding and gene expression control would b… Show more

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Cited by 13 publications
(8 citation statements)
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“…However, according to more recent experimental data, genes not included in 2003 also turned out to encode GPI-APs, such as At1g09460, At2g30933, At2g03505, and At4g13600 (Simpson et al, 2009), LORELEI (Tsukamoto et al, 2010), and XYP2 (Motose et al, 2004). Interestingly, due to recent achievements on alternative splicing, transcriptional variants of SKS3 (Zhou, 2019a) and CRK10 (Grojean and Downes, 2010) have been found to encode GPI-APs besides their ordinarily reported proteins ( Figure 2 ). Alternative splicing largely enhanced the diversity of transcriptome and proteome, and more and more genes (up to 80% according to recent RNA-seq achievements) have been found to be alternatively spliced in Arabidopsis , which could greatly increase the abundance of GPI-APs (Wang et al, 2009; Filichkin et al, 2010; Severing et al, 2011; Reddy et al, 2013; Lee and Rio, 2015; Bush et al, 2017).…”
Section: Prediction and Identification Of Gpi-aps In Arabidopsismentioning
confidence: 99%
“…However, according to more recent experimental data, genes not included in 2003 also turned out to encode GPI-APs, such as At1g09460, At2g30933, At2g03505, and At4g13600 (Simpson et al, 2009), LORELEI (Tsukamoto et al, 2010), and XYP2 (Motose et al, 2004). Interestingly, due to recent achievements on alternative splicing, transcriptional variants of SKS3 (Zhou, 2019a) and CRK10 (Grojean and Downes, 2010) have been found to encode GPI-APs besides their ordinarily reported proteins ( Figure 2 ). Alternative splicing largely enhanced the diversity of transcriptome and proteome, and more and more genes (up to 80% according to recent RNA-seq achievements) have been found to be alternatively spliced in Arabidopsis , which could greatly increase the abundance of GPI-APs (Wang et al, 2009; Filichkin et al, 2010; Severing et al, 2011; Reddy et al, 2013; Lee and Rio, 2015; Bush et al, 2017).…”
Section: Prediction and Identification Of Gpi-aps In Arabidopsismentioning
confidence: 99%
“…Currently, more than twenty classes of riboswitches are known and classified according to their cognate intracellular metabolite [4] . This list of ligands that bind riboswitches has expanded from small molecule metabolites to include second messengers such as cyclic di-guanosine monophosphate (cdGMP) [14] [16] , other RNAs [17] , and possibly hormones [18] .…”
Section: Introductionmentioning
confidence: 99%
“…Although a cytokinin-responsive riboswitch was suggested recently (Grojean and Downes, 2010), the thiamine pyrophosphate (TPP) riboswitch is the only confirmed case in plants thus far (Sudarsan et al, 2003;Bocobza and Aharoni, 2014). However, the TPP riboswitch is clearly distinct from the mechanism controlling AtPSY translation-it involves alternative intron splicing upon TPP-induced 39UTR structural changes, Figure 8.…”
Section: Flux-dependent Translational Control Of Psy Mediated By the mentioning
confidence: 99%