RIBRON: The Spanish online bronchiectasis registry. Characterization of the first 1912 patients

Martínez‐García, Miguel Ángel; Villa, Carmen; Dobarganes, Yadira; Girón, Rosa; Máiz, Luís; García‐Clemente, Marta; Sibila, Oriol; Golpe, Rafael; Rodríguez, Juan; Barreiro, Esther; Menéndez, Rosário; Prados, Concepción; Rosa, David de la; Olveira, y Casilda; Bronquiectasias, en del Grupo Español del Registro representación de

doi:10.1016/j.arbr.2020.11.010

Cited by 48 publications

(59 citation statements)

References 16 publications

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“…These findings were confirmed in the subanalysis after having excluded the COPD patients in both groups. These results are somehow in line with those previously reported [ 13 ], in which airflow limitation was less prominent in female patients with bronchiectasis than in men. In keeping with, disease severity scores were increased in male patients compared to females, despite that the degree of radiological extension was similar between both genders [ 13 ].…”

Section: Discussionsupporting

confidence: 94%

“…This was an observational, cross-sectional, prospective, and multicenter study, in which 43 centers from Spain participated within the frame of the RIBRON database between February 2015 and October 2019 [ 13 ]. The quality of the data introduced in the registry was always monitored and ensured by an external contract research organization (CRO).…”

Section: Methodsmentioning

confidence: 99%

“…The flow-chart of the patient recruitment for the purpose of the study is shown in Figure 1 . Inclusion criteria were adult patients who had been diagnosed with bronchiectasis using a high-resolution computerized tomography (HRCT) [ 4 , 13 , 15 , 16 , 17 , 18 ]. A total number of 2121 patients were analyzed in this study.…”

Section: Methodsmentioning

confidence: 99%

“…On this basis, we hypothesized that levels of systemic inflammatory parameters may differ between male and female patients with bronchiectasis. Thus, the main objectives were to analyze clinical features including systemic inflammatory cellular and soluble parameters in male and female patients with bronchiectasis in a large-cohort of patients from the Spanish Online Bronchiectasis Registry (RIBRON) [ 13 ]. Thus, the specific objectives were to explore potential differences between male and female patients with bronchiectasis as to the following features: (1) lung function, (2) disease severity using several scores, (3) nutritional status, (4) systemic inflammatory parameters, and (5) to assess potential associations between either the inflammatory or the nutritional parameters with the clinical variables in each group of patients.…”

Section: Introductionmentioning

confidence: 99%

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Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study

Wang

Villa²,

Dobarganes³

et al. 2021

Biomedicines

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We hypothesized that systemic inflammatory and nutritional parameters may differ between male and female patients with non-CF bronchiectasis. In a large patient cohort from the Spanish Online Bronchiectasis Registry (RIBRON), clinical features, systemic inflammatory and nutritional parameters were analyzed in male and female patients with bronchiectasis. Lung function, disease severity using several scores, nutritional status, systemic inflammatory parameters, and multivariate regression analyses were performed to identify differences between male and female patients in the target variables. The number of female patients included in the registry was greater than male patients and they had a less severe disease as measured by all three indices of disease severity, a lower degree of airway obstruction, worse diffusion capacity and airway trapping, better nutritional parameters, and lower levels of inflammatory biomarkers. Multivariate regression analysis evidenced that strong relationships were found between female gender and the following variables: total numbers of leukocytes and neutrophils, hemoglobin, hematocrit, creatinine, and body mass index (BMI). Multivariate regression analyses evidenced that nutritional parameters and inflammatory biomarkers may be reliable indicators of gender-related differences in patients with non-CF bronchiectasis. These findings deserve further attention in follow-up investigations in which the potential predictive value of those biomarkers should be thoroughly explored.

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Section: Discussionsupporting

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study

Wang

Villa²,

Dobarganes³

et al. 2021

Biomedicines

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“…Recurrent pneumonia triggers the exacerbation of bronchiectasis in 23 patients (34.32% of all cases, 30% of the abnormal ECG group), which confirms the etiology (postinfections) as a most common etiology in bronchiectasis [ 31 ].…”

Section: Discussionmentioning

confidence: 78%

ECG Abnormalities in Patients with Acute Exacerbation of Bronchiectasis and Factors Associated with High Probability of Abnormality

Alduihi

2021

Pulmonary Medicine

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Background. Bronchiectasis is an important reason for morbidity and mortality according to the last records that referred to high incidence rate of disease. Cardiovascular problems are common in pulmonary diseases, in general, and it can symptom by ECG abnormalities. The objective of this study was to define the most ECG abnormalities in patients with acute exacerbation of bronchiectasis and to study the correlation between the cardiac disorder and the other risk factors of the exacerbation. Materials and Methods. A prospective single-center observational cohort study was done at Aleppo University Hospital for patients with AEB between October 2017 and September 2018. They were divided into 2 groups (normal ECG vs. abnormal). Patients with COPD, cystic fibrosis, new diagnosis of ischemic accident through the last 6 months of the study, and treatment with macrolides or fluoroquinolones through the last 3 months of the study were excluded. We study the percent of abnormalities through the AEB and the percentage of the most common abnormalities. Results. 67 patients were included in the study (44 males and 23 females) with a mean age of 52.85 ± 21.456 . ECG abnormalities were recorded in 43 patients, and it was more common in men (67.44% of cases). Advanced age and survival state had a statistical significance ( p = 0.003 , 0.023), respectively, between the 2 groups. Right axis deviation (RAD) is the most common abnormality (23.3%) followed by sinus tachycardia (20.9%), and it is close to T-depression (18.6%). AF was the most common arrhythmia from all recorded arrhythmias (6.98% from all cases). Positive sputum cultures were recorded in 55.8%, and the most common isolated pathogen factor was Pseudomonas aeruginosa. Recurrent pneumonia was seen in 30.2% of all patients with abnormal ECG. We find a high prevalence of ECG abnormalities in patients with Oximetry (90-95%, 39.5%), and the opportunity for abnormalities is equal in the 2 age groups (45–59 and more than 75) that reflexed the possibility of cardiac disorders in any age in patients with AEB. Conclusions. ECG abnormalities are common in AEB, and it can happen in any age and any value of Oximetry. It needs more attention because of the prognosis of the cardiac morbidity.

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Bronchodilators in bronchiectasis: we urgently need more trials

Martínez‐García

2023

Lung

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RIBRON: The Spanish online bronchiectasis registry. Characterization of the first 1912 patients

Cited by 48 publications

References 16 publications

Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study

Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study

ECG Abnormalities in Patients with Acute Exacerbation of Bronchiectasis and Factors Associated with High Probability of Abnormality

Bronchodilators in bronchiectasis: we urgently need more trials

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