We prove the following result: Let (X, g 0 ) be a complete, connected 4-manifold with uniformly positive isotropic curvature and with bounded geometry. Then there is a finite collection F of manifolds of the form S 3 ×R/G, where G is a discrete subgroup of the isometry group of the round cylinder S 3 × R on which G acts freely, such that X is diffeomorphic to a possibly infinite connected sum of S 4 , RP 4 and members of F. This extends recent work of Chen-Tang-Zhu and Huang. We also extend the above result to the case of orbifolds. The proof uses Ricci flow with surgery on complete orbifolds.