Rice bran, an off-shoot to newer therapeutics in neurological disorders

Behl, Tapan; Kumar, Sachin; Sehgal, Aayush; Singh, Sukhbir; Kumari, Shilpa; Brisc, Mihaela Cristina; Munteanu, Mihai; Brisc, Ciprian; Buhaş, Camelia Liana; Pusta, Claudia Teodora Judea; Nistor-Cseppentö, Delia Carmen; Bungău, Simona

doi:10.1016/j.biopha.2021.111796

Cited by 26 publications

(12 citation statements)

References 106 publications

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“…In this study, neither HRV nor BP variables were statistically significantly improved in either the RBO or RRBO groups, although previous studies have reported that supplementation with rice bran and its antioxidant compounds phenols and anthocyanin enhanced HRV by reducing sympathetic activity, restoring sympathovagal balance, and alleviating vagal nerve inflammation ( Bruno and Ghiadoni, 2018 ; Behl et al, 2021 ; Senaphan et al, 2021 ). Senaphan et al (2021) , in their study on rats fed a high-fat and high-fructose diet, demonstrated that rice bran hydrolysates restored HRV by reducing the low frequency/high frequency ratio and improved blood lipids, insulin sensitivity, hemodynamic variables, cardiac oxidative stress, and cardiac structural changes.…”

Section: Discussioncontrasting

confidence: 81%

Effects of Riceberry Rice Bran Oil Supplementation on Oxidative Stress and Cardiovascular Risk Biomarkers in Older Adults with Prehypertension

Prasertsri

Boonla

Vierra

et al. 2022

Prev. Nutr. Food Sci.

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We investigated the changes in the oxidative stress and cardiovascular disease risk biomarkers, including the activity of the cardiac autonomic nervous system, in older adults with prehypertension following Riceberry rice bran oil supplementation. A total of 35 women aged 60 to 76 years with prehypertension were randomly allocated to two groups, one of which was supplemented with rice bran oil (n=18) and the other with Riceberry rice bran oil (n=17) at 1,000 mg daily for 8 weeks. Prior to and after the supplementation, oxidative stress and cardiovascular risk biomarkers (primary outcomes), heart rate variability, and blood pressure (secondary outcomes) were investigated. Results showed that plasma malondialdehyde, blood glutathione disulfide, and tumor necrosis factor-alpha levels were significantly decreased, and the ratio of reduced glutathione to glutathione disulfide significantly increased in both groups after supplementation (all P<0.05). No significant differences were observed between groups. Heart rate variability and blood pressure did not statistically significantly change subsequent to supplementation in either group and did not differ between groups. In conclusion, Riceberry rice bran oil supplementation for 8 weeks alleviates oxidative stress and inflammation in older adults with prehypertension to a similar extent as rice bran oil supplementation.

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Section: Discussioncontrasting

confidence: 81%

Effects of Riceberry Rice Bran Oil Supplementation on Oxidative Stress and Cardiovascular Risk Biomarkers in Older Adults with Prehypertension

Prasertsri

Boonla

Vierra

et al. 2022

Prev. Nutr. Food Sci.

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show abstract

“…In this study, we did not observe any statistically signi cant improvement in either HRV or BP outcomes in either the RBO or RRBO groups, although previous studies have reported that supplementation with rice bran and its antioxidant compounds, phenols and anthocyanin, improved HRV by reducing sympathetic activity, reestablishing sympathovagal balance, and alleviating vagal nerve in ammation [16,52,53]. A study by Senaphan et al [53] in rats fed a high fat, high fructose diet showed that rice bran hydrolysates restored HRV by decreasing the LF/HF ratio and improved lipid pro les, insulin sensitivity, hemodynamic parameters, cardiac oxidative stress (decreased MDA and protein carbonyl, upregulated eNOS expression, and increased catalase activity), and cardiac structural changes (reduced cardiac hypertrophy and myocardial brosis).…”

Section: Discussioncontrasting

confidence: 72%

Effects of Riceberry rice bran oil supplementation on oxidative stress, cardiovascular risk biomarkers, and cardiac autonomic nervous system activity in older adults with prehypertension

Prasertsri

Boonla

Vierra

et al. 2022

Preprint

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Background In this study, we aimed to measure the changes in the biomarkers of oxidative stress, cardiovascular disease risk, and the activity of the cardiac autonomic nervous system in older adults with prehypertension after supplementation with Riceberry rice bran oil. Methods In total, 35 women aged 60–76 years with prehypertension were randomly allocated to two groups, one of which was supplemented with rice bran oil (n = 18) and the other with Riceberry rice bran oil (n = 17) at 1,000 mg (500 mg × 2 capsules) daily for 8 weeks. The primary outcomes, including oxidative stress and cardiovascular risk biomarkers, and secondary outcomes, including heart rate variability and blood pressure, were determined before and after the 8-week supplementation. Results The levels of plasma malondialdehyde, blood glutathione disulfide, and tumor necrosis factor-alpha were significantly decreased, and the ratio of reduced glutathione to glutathione disulfide significantly increased in both groups after supplementation (all p < 0.05). No significant differences were noted between groups. Heart rate variability and blood pressure were not statistically significantly different after supplementation in both groups. Conclusions Supplementation with Riceberry rice bran oil for 8 weeks may attenuate oxidative stress and inflammation in older adults with prehypertension. The effects of a longer supplementation period or use in hypertensive persons should be further investigated, especially with regard to blood pressure and cardiac autonomic nervous system activity. Trial registration: This trial was registered March 22, 2019 at https://www.thaiclinicaltrials.org as TCTR20190322002.

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“…Several food-derived peptides have been reported to improve cognitive function 16 , 50 , 51 ; however, higher concentrations and more frequent administration than rice-memolin were required. On the other hand, prevention of cognitive decline by processed rice bran was reported, but functional substances were not cleared and some of them were considered as γ-oryzanol 52 – 55 . Rice-memolin is orally active and the most potent cognition-improving peptide derived from food to the best of our knowledge.…”

Section: Discussionmentioning

confidence: 99%

Rice-memolin, a novel peptide derived from rice bran, improves cognitive function after oral administration in mice

Shobako

Zhang

et al. 2023

Sci Rep

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Many people eat polished rice, while rice bran, a by-product known to be rich in protein and expected to have potential functions for health benefits, has not been effectively utilized. In this study, we determined that orally administered Val-Tyr-Thr-Pro-Gly (VYTPG) derived from rice bran protein improved cognitive decline in mice fed a high-fat diet (HFD). It was demonstrated that VYTPG was released from model peptides corresponding to fragment sequences of original rice proteins (Os01g0941500, Os01g0872700, and allergenic protein) after treatment with thermolysin, a microorganism-derived enzyme often used in industrial scale processes. The thermolysin digest also improved cognitive decline after oral administration in mice. Because VYTPG (1.0 mg/kg) potently improved cognitive decline and is enzymatically produced from the rice bran, we named it rice-memolin. Next, we investigated the mechanisms underlying the cognitive decline improvement associated with rice-memolin. Methyllycaconitine, an antagonist for α7 nicotinic acetylcholine receptor, suppressed the rice-memolin-induced effect, suggesting that rice-memolin improved cognitive decline coupled to the acetylcholine system. Rice-memolin increased the number of 5-bromo-2’-deoxyuridine (BrdU)-positive cells and promoted the mRNA expression of EGF and FGF-2 in the hippocampus, implying that these neurotropic factors play a role in hippocampal neurogenesis after rice-memolin administration. Epidemiologic studies demonstrated that diabetes is a risk factor for dementia; therefore, we also examined the effect of rice-memolin on glucose metabolism. Rice-memolin improved glucose intolerance. In conclusion, we identified a novel rice-derived peptide that can improve cognitive decline. The mechanisms are associated with acetylcholine and hippocampal neurogenesis. Rice-memolin is the first rice-brain-derived peptide able to improve cognitive decline.

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Rice bran, an off-shoot to newer therapeutics in neurological disorders

Cited by 26 publications

References 106 publications

Effects of Riceberry Rice Bran Oil Supplementation on Oxidative Stress and Cardiovascular Risk Biomarkers in Older Adults with Prehypertension

Effects of Riceberry Rice Bran Oil Supplementation on Oxidative Stress and Cardiovascular Risk Biomarkers in Older Adults with Prehypertension

Effects of Riceberry rice bran oil supplementation on oxidative stress, cardiovascular risk biomarkers, and cardiac autonomic nervous system activity in older adults with prehypertension

Rice-memolin, a novel peptide derived from rice bran, improves cognitive function after oral administration in mice

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