Rice Bran Oil Compared to Atorvastatin for Treatment of Dyslipidemia in Patients with Type 2 Diabetes

Shakib, Marie-Christine R.; Gabrial, Shreef G. N.; Gabrial, G. N.

doi:10.3889/oamjms.2014.017

Cited by 15 publications

(8 citation statements)

References 58 publications

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“…The profound influence of lycopene singly and in blend with RBO tended to nullify the effect and refurbish the levels. The protective effect can be attributed to their antilipemic and antioxidative potential confirming to previous studies [79][80][81][82][83]. Furthermore, upsurge protein levels in lycopene treated rats suggest the regeneration of liver cells henceforth corroborating their hepatoprotective property against deleterious effects of hyperlipidemia mediated oxidative stress as in accord with previous studies [79,84].…”

Section: Discussionsupporting

confidence: 89%

Alterations in Lipid-Lipoprotein Fractions and Antioxidant Status by Lycopene and its Blends with Rice Bran Oil in Nutritionally Induced Hyperlipidemic Animal Model

Chauhan

2017

J. Nutr. Ther.

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Nutrition Transition in the latter half of 20 th century has prompted profound shift from traditional dietary pattern of fibre rich foods to increased consumption of energy dense, high fat and low fibre foods. Resultant oblivious nutritional environment coupled with physical inactivity has abridged the gap between health and chronic diseases. Consequently, the paradigm of treatment from pharmaceuticals has shifted to neutraceuticals and a large proportion of populace is resorting to cost effective treatments from natural sources that can contribute effectually in combating these dreadful diseases. The present study was undertaken to evaluate the efficacy of blends of lycopene and rice bran oil (RBO) on alteration in lipid metabolism and oxidative stress biomarkers in high fat high cholesterol diet fed albino rats. The rats were supplemented with lycopene (30mg/kg/day) singly and blend of lycopene (30mg/kg/day) and rice bran oil (100ml/kg/day) for 6 weeks. Results indicate that lycopene enriched diets significantly (p≤0.05) improved altered parameters, however, the effect was more pronounced in animals reared on blends of lycopene and RBO. The therapeutic potential of lycopene and RBO can be tapped as preventive and protective therapy against the detrimental effects of high fat diets consumed globally.

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Section: Discussionsupporting

confidence: 89%

Alterations in Lipid-Lipoprotein Fractions and Antioxidant Status by Lycopene and its Blends with Rice Bran Oil in Nutritionally Induced Hyperlipidemic Animal Model

Chauhan

2017

J. Nutr. Ther.

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“…RBO is a rich source of MUFA (44%), PUFA (33.6%), tocopherols, tocotrienols, and phytosterol [ 47 ], and is thus a popular cooking oil in Asia and tropical countries. RBO also contains γ-oryzanol, which has antioxidant properties [ 48 ] and has been shown to improve lipid profiles [ 49 , 50 , 51 ]. Our study findings indicate the favorable effect of RBO in decreasing both LDL-c and TC levels.…”

Section: Discussionmentioning

confidence: 99%

Tropical Oil Consumption and Cardiovascular Disease: An Umbrella Review of Systematic Reviews and Meta Analyses

et al. 2021

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The health effects of saturated fat, particularly tropical oil, on cardiovascular disease are unclear. We investigated the effect of tropical oil (palm and coconut oils), lard, and other common vegetable oils (soybean and rice bran oils) that are widely used in tropical and Asian countries on lipid profiles. We performed an umbrella review of meta-analyses and systematic reviews. Electronic databases (Medline, Scopus, Embase, and Cochrane) were searched up to December 2018 without language restriction. We identified nine meta-analyses that investigated the effect of dietary oils on lipid levels. Replacement of polyunsaturated fatty-acid-rich oils (PUFAs) and monounsaturated FA-rich oils (MUFAs) with palm oil significantly increased low-density lipoprotein cholesterol (LDL-c), by 3.43 (0.44–6.41) mg/dL and 9.18 (6.90–11.45) mg/dL, respectively, and high-density lipoprotein cholesterol (HDL-c), by 1.89 (1.23–2.55) mg/dL and 0.94 (−0.07–1.97) mg/dL, respectively. Replacement of PUFAs with coconut oil significantly increased HDL-c and total cholesterol –by 2.27 (0.93–3.6) mg/dL and 5.88 (0.21–11.55) mg/dL, respectively—but not LDL-c. Substituting lard for MUFAs and PUFAs increased LDL-c–by 8.39 (2.83–13.95) mg/dL and 9.85 (6.06–13.65) mg/dL, respectively—but not HDL-c. Soybean oil substituted for other PUFAs had no effect on lipid levels, while rice bran oil substitution decreased LDL-c. Our findings show the deleterious effect of saturated fats from animal sources on lipid profiles. Replacement of unsaturated plant-derived fats with plant-derived saturated fats slightly increases LDL-c but also increases HDL-c, which in turn may exert a neutral effect on cardiovascular health.

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“…It has also been mentioned that γ-oryzanol, in addition to tocotrienols, might promote cholesterol 7-alpha-hydroxylase (CYP7A1), the enzyme with rate restriction ability in the synthesis of cholesterol, which stabilizes serum cholesterol concentration by modulating cholesterol-bile acids conversion [ 33 , 37 , 53 ]. With respect to these mechanisms, RBO has also been shown to ameliorate insulin resistance and attenuate lipotoxicity and glucotoxicity [ 32 , 35 , 37 , 43 – 46 , 48 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Rice bran oil could favorably ameliorate atherogenicity and insulin resistance indices among men with coronary artery disease: post hoc analysis of a randomized controlled trial

et al. 2021

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Background Despite recent advances in recognizing more reliable indicators to estimate the coronary artery disease (CAD) patients’ response to treatment and prognosis, less attention has been paid to evaluating them in clinical trials. Hence, the present research was conducted to study the impact of rice bran oil (RBO) versus sunflower oil (SFO) on various atherogenicity and insulin resistance markers. Methods In the present 8-week randomized controlled trial, 40 CAD men with an average age of 56 years were allocated randomly into the intervention or control group to use RBO or SFO (30 g/day) plus a standardized dietary plan. As a further analysis, eight atherosclerosis-related indices were calculated before and after the study. Results Analysis of covariance test in which potential confounders and baseline levels were considered, indicated that using RBO compared to SFO reduced Castelli’s risk index I and II (adjusted means:3.29, 1.52 vs. 4.61, 2.20, respectively), atherogenic coefficient (2.29 vs. 3.61), lipoprotein combine index (6.54 vs. 17.53), and cholesterol index (0.46 vs. 1.20) after the trial (P-value ≤ 0.002). Also, the RBO group yielded significantly lower triglyceride glucose index (8.73 vs. 9.13) (P-value = 0.010). Further, marginally significant amelioration in triglyceride/HDL ratio and atherogenic index of plasma (1.48 and 0.13 vs. 1.86 and 0.24 respectively) were noted (P-value = 0.07). Spearman correlation analysis detected significant positive correlations between alterations in TNF-α serum levels (ng/L) and the majority of evaluated indices (P-value < 0.05). Conclusion Taken together, incorporating 30 g of RBO into the patient’s usual diet appeared effective in ameliorating atherogenicity and insulin resistance indicators among men with CAD, probably in relation to its anti-inflammatory properties. Trial registration The protocol of the current trial was retrospectively recorded in the Iranian clinical trial registration system (IRCT) with the registration number of IRCT20190313043045N1 (URL: https://en.irct.ir/trial/38346; Registration date: 2019-04-27).

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Rice Bran Oil Compared to Atorvastatin for Treatment of Dyslipidemia in Patients with Type 2 Diabetes

Cited by 15 publications

References 58 publications

Alterations in Lipid-Lipoprotein Fractions and Antioxidant Status by Lycopene and its Blends with Rice Bran Oil in Nutritionally Induced Hyperlipidemic Animal Model

Alterations in Lipid-Lipoprotein Fractions and Antioxidant Status by Lycopene and its Blends with Rice Bran Oil in Nutritionally Induced Hyperlipidemic Animal Model

Tropical Oil Consumption and Cardiovascular Disease: An Umbrella Review of Systematic Reviews and Meta Analyses

Rice bran oil could favorably ameliorate atherogenicity and insulin resistance indices among men with coronary artery disease: post hoc analysis of a randomized controlled trial

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